Stock

FESA Number

2900

Strain Name

129(B6)-Apoe<tm1Bres> Plg<tm1Jld>/CljH[cc]

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Apoe<tm1Bres> MGI:2137814 Apoe MGI:88057 7
Plg<tm1Jld> MGI:1857291 Plg MGI:97620 17

Phenotypic Description

Rectal prolapse. Shortened life span in homozygotes.

Orphanet Disorders

Publications

Displaying 11 - 20 of 171 Stock Publications
Pubmed ID Authors Title Journal
17301181 Sheehan JJ Proteolytic activation of monocyte chemoattractant protein-1 by plasmin underlies excitotoxic neurodegeneration in mice. J Neurosci (2 007) 27:1738-45
15126104 Afek A Evidence for the involvement of T cell costimulation through the B-7/CD28 pathway in atherosclerotic plaques from apolipoprotein E knockout mice. Exp Mol Pathol (2 004) 76:219-23
12600880 Deng GG Urokinase-type plasminogen activator plays a critical role in angiotensin II-induced abdominal aortic aneurysm. Circ Res (2 003) 92:510-7
22366371 Huang Y Aberrant expression of Fc?RIIIA (CD16) contributes to the development of atherosclerosis. Gene (2 012) 498:91-5
15466367 Lee SJ Chylomicron remnant uptake in the livers of mice expressing human apolipoproteins E3, E2 (Arg158--&gt;Cys), and E3-Leiden. J Lipid Res (2 004) 45:2199-210
10195942 Plump AS Increased atherosclerosis in ApoE and LDL receptor gene knock-out mice as a result of human cholesteryl ester transfer protein transgene expression. Arterioscler Thromb Vasc Biol (1 999) 19:1105-10
15694415 Shimshi M Bisphosphonates induce inflammation and rupture of atherosclerotic plaques in apolipoprotein-E null mice. Biochem Biophys Res Commun (2 005) 328:790-3
16325305 Wang ZJ Alteration of vascular urotensin II receptor in mice with apolipoprotein E gene knockout. Peptides (2 006) 27:858-63
9373263 Bugge TH Growth and dissemination of Lewis lung carcinoma in plasminogen-deficient mice. Blood (1 997) 90:4522-31
18337830 Green KA Profibrinolytic effects of metalloproteinases during skin wound healing in the absence of plasminogen. J Invest Dermatol (2 008) 128:2092-101

Pages

Orphanet Categories

Rare systemic or rheumatologic disease
Rare eye disease

EMMA ID

EM:02065

Genetic Status

GMO

Background Strain Name

129

Background Strain MGI ID

MGI:2160041

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