Stock

FESA Number

1838

Strain Name

129-Foxa2<tm1Jrt>/H

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - unclassified

Attribution

Institution name Depositor / Originator Name
University of Oxford Originator Retained
University of Oxford Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Foxa2<tm1Jrt> MGI:1857725 Foxa2 MGI:1347476 2

Phenotypic Description

Homozygous lethal at day 8 of gestation. This mouse strain has a pre-disposition to develop mis-aligned jaws which leads to over grown teeth.

Publications

Displaying 1 - 10 of 17 Stock Publications
Pubmed ID Authors Title Journal
15231714 Abdelkhalek HB The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation. Genes Dev (2 004) 18:1725-36
16839541 Yang YP Roles of organizer factors and BMP antagonism in mammalian forebrain establishment. Dev Biol (2 006) 296:458-75
8069909 Ang SL HNF-3 beta is essential for node and notochord formation in mouse development. Cell (1 994) 78:561-74
8610012 Collignon J Relationship between asymmetric nodal expression and the direction of embryonic turning. Nature (1 996) 381:155-8
9671576 Dufort D The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis. Development (1 998) 125:3015-25
9226455 Filosa S Goosecoid and HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis. Development (1 997) 124:2843-54
11846474 Hallonet M Maintenance of the specification of the anterior definitive endoderm and forebrain depends on the axial mesendoderm: a study using HNF3beta/Foxa2 conditional mutants. Dev Biol (2 002) 243:20-33
11291866 Jin O Otx2 and HNF3beta genetically interact in anterior patterning. Int J Dev Biol (2 001) 45:357-65
11291865 Kinder SJ Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity. Int J Dev Biol (2 001) 45:347-55
18076286 Kittappa R The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol (2 007) 5:e325

Pages

EMMA ID

EM:02526

Contact/Order

For more information or to order stocks, Contact us