Stock 129-Elane<tm1(cre)Roes>/H

FESA Number

1557

Strain Name

129-Elane<tm1(cre)Roes>/H

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Elane<tm1(cre)Roes> MGI:2182177 Elane MGI:2679229 10

Phenotypic Description

Homozygotes have impaired neutrophil recruitment and impaired innate immunity.

Orphanet Disorders

OrphaNet ID Name Url
486 Autosomal dominant severe congenital neutropenia http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=486
2 686 Cyclic neutropenia http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=2686

Publications

Displaying 11 - 11 of 11 Stock Publications
Pubmed ID Authors Title Journal
10714686 Tkalcevic J Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G. Immunity (2 000) 12:201-10

Pages

Orphanet Categories

Rare immune disease

EMMA ID

EM:00075

Genetic Status

GMO

Production Information

Cre-Lox Recombination based excision

Background Strain Name

129

Background Strain MGI ID

MGI:2160041

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