Stock

FESA Number

1564

Strain Name

129-Elane<tm1(cre)Roes>Ctsg<tm1.1Roes>/H

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Elane<tm1(cre)Roes> MGI:2182177 Elane MGI:2679229 10
Ctsg<tm1.1Roes> MGI:2182170 Ctsg MGI:88563 14

Phenotypic Description

Impaired innate immunity.

Publications

Displaying 11 - 16 of 16 Stock Publications
Pubmed ID Authors Title Journal
10714686 Tkalcevic J Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G. Immunity (2 000) 12:201-10
19039769 Birkner K The elimination of Anaplasma phagocytophilum requires CD4+ T cells, but is independent of Th1 cytokines and a wide spectrum of effector mechanisms. Eur J Immunol (2 008) 38:3395-410
21911460 Hahn I Cathepsin G and neutrophil elastase play critical and nonredundant roles in lung-protective immunity against Streptococcus pneumoniae in mice. Infect Immun (2 011) 79:4893-901
23934850 Rafatian N Cathepsin G deficiency decreases complexity of atherosclerotic lesions in apolipoprotein E-deficient mice. Am J Physiol Heart Circ Physiol (2 013) 305:H1141-8
22461690 Steinwede K Cathepsin G and neutrophil elastase contribute to lung-protective immunity against mycobacterial infections in mice. J Immunol (2 012) 188:4476-87
10714686 Tkalcevic J Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G. Immunity (2 000) 12:201-10

Pages

EMMA ID

EM:00074

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