Stock 129-Elane<tm1(cre)Roes>Ctsg<tm1.1Roes>/H

FESA Number


Strain Name


Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - unclassified


Institution name Depositor / Originator Name
University College London Originator Retained
University College London Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Elane<tm1(cre)Roes> MGI:2182177 Elane MGI:2679229 10
Ctsg<tm1.1Roes> MGI:2182170 Ctsg MGI:88563 14

Phenotypic Description

Impaired innate immunity.


Displaying 1 - 10 of 16 Stock Publications
Pubmed ID Authors Title Journal
19039769 Birkner K The elimination of Anaplasma phagocytophilum requires CD4+ T cells, but is independent of Th1 cytokines and a wide spectrum of effector mechanisms. Eur J Immunol (2 008) 38:3395-410
17200183 Chua F Mice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis. Am J Pathol (2 007) 170:65-74
21849484 Glenthøj A Serglycin participates in retention of ?-defensin in granules during myelopoiesis. Blood (2 011) 118:4440-8
21911460 Hahn I Cathepsin G and neutrophil elastase play critical and nonredundant roles in lung-protective immunity against Streptococcus pneumoniae in mice. Infect Immun (2 011) 79:4893-901
18536720 Heit B PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils. Nat Immunol (2 008) 9:743-52
22711877 Hyun YM Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels. J Exp Med (2 012) 209:1349-62
18568075 Kessenbrock K Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. J Clin Invest (2 008) 118:2438-47
25278585 Lerman YV Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin ?3?1-dependent. Blood (2 014) 124:3515-23
22461690 Steinwede K Cathepsin G and neutrophil elastase contribute to lung-protective immunity against mycobacterial infections in mice. J Immunol (2 012) 188:4476-87
14975240 Thomas RM C-terminal SRC kinase controls acute inflammation and granulocyte adhesion. Immunity (2 004) 20:181-91





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