Stock
FESA Number
1564
Strain Name
129-Elane<tm1(cre)Roes>Ctsg<tm1.1Roes>/H
Mutation Strain Type
| Mutation Type | Mutation Subtype | Strain Type |
|---|---|---|
| IMSR - Targeted mutation | IMSR - unclassified |
Attribution
| Institution name | Depositor / Originator | Name |
|---|---|---|
| University College London | Originator | Retained |
| University College London | Depositor | Retained |
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Elane<tm1(cre)Roes> | MGI:2182177 | Elane | MGI:2679229 | 10 |
| Ctsg<tm1.1Roes> | MGI:2182170 | Ctsg | MGI:88563 | 14 |
Phenotypic Description
Impaired innate immunity.
Publications
Displaying 1 - 10 of 16 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 19039769 | Birkner K | The elimination of Anaplasma phagocytophilum requires CD4+ T cells, but is independent of Th1 cytokines and a wide spectrum of effector mechanisms. | Eur J Immunol (2 008) 38:3395-410 |
| 17200183 | Chua F | Mice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis. | Am J Pathol (2 007) 170:65-74 |
| 21849484 | Glenthøj A | Serglycin participates in retention of ?-defensin in granules during myelopoiesis. | Blood (2 011) 118:4440-8 |
| 21911460 | Hahn I | Cathepsin G and neutrophil elastase play critical and nonredundant roles in lung-protective immunity against Streptococcus pneumoniae in mice. | Infect Immun (2 011) 79:4893-901 |
| 18536720 | Heit B | PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils. | Nat Immunol (2 008) 9:743-52 |
| 22711877 | Hyun YM | Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels. | J Exp Med (2 012) 209:1349-62 |
| 18568075 | Kessenbrock K | Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. | J Clin Invest (2 008) 118:2438-47 |
| 25278585 | Lerman YV | Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin ?3?1-dependent. | Blood (2 014) 124:3515-23 |
| 22461690 | Steinwede K | Cathepsin G and neutrophil elastase contribute to lung-protective immunity against mycobacterial infections in mice. | J Immunol (2 012) 188:4476-87 |
| 14975240 | Thomas RM | C-terminal SRC kinase controls acute inflammation and granulocyte adhesion. | Immunity (2 004) 20:181-91 |
Pages
EMMA ID
EM:00074
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