Strain NameGene/Allele SymbolChrPhenotypeAvailability
129P2/OlaHsd-Prnp<tm
2Edin>/H 		Prnp<tm2Edin> 2No expression of the Prnp gene. Abnormalities in synaptic transmission, circadian rhythm and sleep. Increased susceptability to oxidative stress and copper toxicity. Cellular phenotypes in T cell activation.Order From EMMA
C3H.Cg-Sgh/H Sgh 4Mice carrying this mutation demonstrate a low endurance of wheel running activity which is reduced to about 10% of control values.Order From EMMA
PLAY19 Identified in circadian rhythm screen. Potentially no entrainment response to light pulses given at CT16Order From EMMA
C(C3)-Play16/H No entrainment response to light pulses given at CT16.Order From EMMA
C3H;C-Play44/H Identified in circadian rhythm screen. Potentially shows a large entrainment response to light and phase advancement in a 12:12 light:dark cycle.Order From EMMA
C3H;C-Play40/H Identified in circadian rhythm screen. Mutants have potentially no entrainment response to light.Order From EMMA
C3H.Cg-Play1/H These mice have a higher than normal degree of daytime activity in a 12:12 light:dark cycle.Order From EMMA
C3H;C-Play46/H Play46 UNPoor entrainment to light in 12:12 light dark: cycle.Order From EMMA
C3H.Cg-Play31/H Identified in a circadian rhythm screen. Wheel turning activity is dramatically reduced in a 12:12 light:dark cycle.Order From EMMA
C3H;C-Play32/H Identified in a circadian rhythm screen. These mice have reduced bouts of wheel running activity in a 12:12 light:dark cycle. Order From EMMA
C3H;C-Play47/H Identified in circadian rhythm screen. These mice free run in a 12:12 light:dark cycle.Order From EMMA
C3H;C-Sbc/H Sbc 16Identified in circadian rhythm screen. These mice change their period length from normal to long after a light pulse is given at CT16 (circadian time).Order From EMMA
C3H.Cg-Sci/H Sci 8Identified in circadian rhythm screen. Short circadian period of wheel-running activity (22.5 hrs rather than 23.5 hrs). Wheel running activity is about 10% of control animals.Order From EMMA
C3H;C-Play63/H Reduced bouts of wheel- running activity.Order From EMMA
C3H;C-Play50/H Play50 UNIdentified in circadian rhythm screen. Reduced bouts of wheel- running activityOrder From EMMA
C3H.Cg-Sfl/H Sfl 2Identified in circadian rhythm screen. Mice carrying this mutation have no phase shifting response to a light pulse given at CT16. Order From EMMA
C3H.Cg-Fbxl3<Afh>/H Fbxl3<Afh> 14Identified in circadian rhythm screen. Mutants have a long circadian period 24.23hr (a) and 24.12hr (b).Order From EMMA
C3H;C-Play41/H Play41 UNIdentified in circadian rhythm screen. Mutant mice demonstrate a long circadian period (24-24.5hr), and reduced activity.Order From EMMA
C3H;C-Play57/H Play57 UNIdentified in circadian rhythm screen. Mutant mice demonstrate a shorter cicadian wild type.Order From EMMA
C3H;C-Play36/H Play36 UNIdentified by circadian rhythm screen. Mutant mice demonstrate an increased phase shift after light pulse.Order From EMMA
C3H;C-Play42/H Identified in a circadian rhythm screen. These mice have two sets of activity onsets when first exposed to constant darkness conditions.Order From EMMA
C3H;C-Play82/H This mutation was identified in a circadian rhythm screen. It shows reduced bouts of wheel-running activity.Order From EMMA
C3H;C-Play81/H Long circadian period & poor entrainment responseOrder From EMMA
CIRCA12 Identified in circadian rhythm screen. Has a reduced period lengthening response when subjected to constant light conditions.Order
EMMA ID gene symbol - click to view MGI mutant alleles common strain name(s) - click for the strain description (International) Strain Designation click to order/ register an interest
EM:00144Unknown at presentPLAY1C3H.Cg-Play1/Horder
EM:00148Unknown at presentPLAY31PLAY31order
EM:00149Unknown at presentPLAY32C3H;C-Play32/Horder
EM:00151Unknown at presentPLAY42PLAY42order
EM:00153Play46PLAY46C3H;C-Play46/Horder
EM:00154Unknown at presentPLAY47C3H;C-Play47/Horder
EM:00155SbcPLAY7C3H;C-Sbc/Horder
EM:00156SciPLAY8C3H.Cg-Sci/Horder
EM:00571Creb1CREB Ser142B6.129P2-Creb1tm4Gsc/Ibcmorder
EM:00701Unknown at presentPLAY 81PLAY81order
EM:00704Unknown at presentPLAY 79PLAY79order
EM:00705Unknown at presentPLAY 82PLAY82order
EM:01188Play57PLAY57C3H;C-Play57/Horder
EM:01248Play41PLAY 41C3H;C-Play41/Horder
EM:01719PrnpPrnp129P2/OlaHsd-Prnptm2Edin/Horder
EM:01841Fbxl3PLAY68C3H;C-Fbxl3Afh/Horder
EM:02485DbpDBP-KOB6;129P2-Dbptm1Schb/Ibcmorder
EM:02487Nr1d1REV-ERBalpha-KOB6.129-Nr1d1tm1Schb/Ibcmorder

Barnard, A.R. Nolan, P.M. When clocks go bad: neurobehavioural consequences of disrupted circadian timing. PLOS Genetics. 2008 (4 (5)) :www.plosgenetics.org e1000040. doi:10.1371/journal.pgen.1000040

Cameron, M. Barnard, A.R. Lucas, R.J. The electroretinogram as a method for studying circadian rhythms in the mammalian retina. Journal of Genetics. 2008 (87) :459-466

Busino, L. Bassermann, F. Maiolica, A. Lee, C. Nolan, P.M. Godinho, S.I.H. Draetta, G.F. Pagano, M. SCFFbx13 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. Science. 2007 (316) :900-904

Godinho, S.I.H. Maywood, E.S. Shaw, L. Tucci, V. Barnard, A.R. Busino, L. Pagano, M. Kendall, R. Quwailid, M.M. Romero, M.R. O'Neill, J. Chesham, J.E. Brooker, D. Lalanne, Z. Hastings, M.H. Nolan, P.M. The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period. Science. 2007 (316) :897-900