Imprinting Details for Nnat

Imprinting Loci	Chromosome	Chromosomal Region	Expressed parental allele: maternal (M)/ paternal (P)	Name
Nnat	2	dist 2	P	neuronatin
Gene Synonyms
Peg5
Gene References
Tamplin OJ,Kinzel D,Cox BJ,Bell CE,Rossant J,Lickert H Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. BMC genomics. 2008();9():511 PUBMED
Wilding Crawford L,Tweedie Ables E,Oh YA,Boone B,Levy S,Gannon M Gene expression profiling of a mouse model of pancreatic islet dysmorphogenesis. PLoS ONE. 2008();3(2):e1611 PUBMED
Labialle S,Yang L,Ruan X,Villemain A,Schmidt JV,Hernandez A,Wiltshire T,Cermakian N,Naumova AK Coordinated diurnal regulation of genes from the Dlk1-Dio3 imprinted domain: implications for regulation of clusters of non-paralogous genes. Human molecular genetics. 2008();17(1):15-26 PUBMED
Kamei Y,Suganami T,Kohda T,Ishino F,Yasuda K,Miura S,Ezaki O,Ogawa Y Peg1/Mest in obese adipose tissue is expressed from the paternal allele in an isoform-specific manner. FEBS letters. 2007();581(1):91-6 PUBMED
Petri A,Ahnfelt-Rønne J,Frederiksen KS,Edwards DG,Madsen D,Serup P,Fleckner J,Heller RS The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice. Journal of molecular endocrinology. 2006();37(2):301-16 PUBMED
Ogawa H,Wu Q,Komiyama J,Obata Y,Kono T Disruption of parental-specific expression of imprinted genes in uniparental fetuses. FEBS letters. 2006();580(22):5377-84 PUBMED
Fukasawa M,Morita S,Kimura M,Horii T,Ochiya T,Hatada I Genomic imprinting in Dicer1-hypomorphic mice. Cytogenetic and genome research. 2006();113(1-4):138-43 PUBMED
Carninci P,Kasukawa T,Katayama S,Gough J,Frith MC,Maeda N,Oyama R,Ravasi T,Lenhard B,Wells C,Kodzius R,Shimokawa K,Bajic VB,Brenner SE,Batalov S,Forrest AR,Zavolan M,Davis MJ,Wilming LG,Aidinis V,Allen JE,Ambesi-Impiombato A,Apweiler R,Aturaliya RN,Bailey TL,Bansal M,Baxter L,Beisel KW,Bersano T,Bono H,Chalk AM,Chiu KP,Choudhary V,Christoffels A,Clutterbuck DR,Crowe ML,Dalla E,Dalrymple BP,de Bono B,Della Gatta G,di Bernardo D,Down T,Engstrom P,Fagiolini M,Faulkner G,Fletcher CF,Fukushima T,Furuno M,Futaki S,Gariboldi M,Georgii-Hemming P,Gingeras TR,Gojobori T,Green RE,Gustincich S,Harbers M,Hayashi Y,Hensch TK,Hirokawa N,Hill D,Huminiecki L,Iacono M,Ikeo K,Iwama A,Ishikawa T,Jakt M,Kanapin A,Katoh M,Kawasawa Y,Kelso J,Kitamura H,Kitano H,Kollias G,Krishnan SP,Kruger A,Kummerfeld SK,Kurochkin IV,Lareau LF,Lazarevic D,Lipovich L,Liu J,Liuni S,McWilliam S,Madan Babu M,Madera M,Marchionni L,Matsuda H,Matsuzawa S,Miki H,Mignone F,Miyake S,Morris K,Mottagui-Tabar S,Mulder N,Nakano N,Nakauchi H,Ng P,Nilsson R,Nishiguchi S,Nishikawa S,Nori F,Ohara O,Okazaki Y,Orlando V,Pang KC,Pavan WJ,Pavesi G,Pesole G,Petrovsky N,Piazza S,Reed J,Reid JF,Ring BZ,Ringwald M,Rost B,Ruan Y,Salzberg SL,Sandelin A,Schneider C,Schönbach C,Sekiguchi K,Semple CA,Seno S,Sessa L,Sheng Y,Shibata Y,Shimada H,Shimada K,Silva D,Sinclair B,Sperling S,Stupka E,Sugiura K,Sultana R,Takenaka Y,Taki K,Tammoja K,Tan SL,Tang S,Taylor MS,Tegner J,Teichmann SA,Ueda HR,van Nimwegen E,Verardo R,Wei CL,Yagi K,Yamanishi H,Zabarovsky E,Zhu S,Zimmer A,Hide W,Bult C,Grimmond SM,Teasdale RD,Liu ET,Brusic V,Quackenbush J,Wahlestedt C,Mattick JS,Hume DA,Kai C,Sasaki D,Tomaru Y,Fukuda S,Kanamori-Katayama M,Suzuki M,Aoki J,Arakawa T,Iida J,Imamura K,Itoh M,Kato T,Kawaji H,Kawagashira N,Kawashima T,Kojima M,Kondo S,Konno H,Nakano K,Ninomiya N,Nishio T,Okada M,Plessy C,Shibata K,Shiraki T,Suzuki S,Tagami M,Waki K,Watahiki A,Okamura-Oho Y,Suzuki H,Kawai J,Hayashizaki Y, , The transcriptional landscape of the mammalian genome. Science (New York, N.Y.). 2005();309(5740):1559-63 PUBMED
Chu K,Tsai MJ Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion. Diabetes. 2005();54(4):1064-73 PUBMED
Show 13 more Gene References below

Blackshaw S,Harpavat S,Trimarchi J,Cai L,Huang H,Kuo WP,Weber G,Lee K,Fraioli RE,Cho SH,Yung R,Asch E,Ohno-Machado L,Wong WH,Cepko CL Genomic analysis of mouse retinal development. PLoS biology. 2004();2(9):E247 PUBMED
Sousa-Nunes R,Rana AA,Kettleborough R,Brickman JM,Clements M,Forrest A,Grimmond S,Avner P,Smith JC,Dunwoodie SL,Beddington RS Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection. Genome research. 2003();13(12):2609-20 PUBMED
Mager J,Montgomery ND,de Villena FP,Magnuson T Genome imprinting regulated by the mouse Polycomb group protein Eed. Nature genetics. 2003();33(4):502-7 PUBMED
Okazaki Y,Furuno M,Kasukawa T,Adachi J,Bono H,Kondo S,Nikaido I,Osato N,Saito R,Suzuki H,Yamanaka I,Kiyosawa H,Yagi K,Tomaru Y,Hasegawa Y,Nogami A,Schönbach C,Gojobori T,Baldarelli R,Hill DP,Bult C,Hume DA,Quackenbush J,Schriml LM,Kanapin A,Matsuda H,Batalov S,Beisel KW,Blake JA,Bradt D,Brusic V,Chothia C,Corbani LE,Cousins S,Dalla E,Dragani TA,Fletcher CF,Forrest A,Frazer KS,Gaasterland T,Gariboldi M,Gissi C,Godzik A,Gough J,Grimmond S,Gustincich S,Hirokawa N,Jackson IJ,Jarvis ED,Kanai A,Kawaji H,Kawasawa Y,Kedzierski RM,King BL,Konagaya A,Kurochkin IV,Lee Y,Lenhard B,Lyons PA,Maglott DR,Maltais L,Marchionni L,McKenzie L,Miki H,Nagashima T,Numata K,Okido T,Pavan WJ,Pertea G,Pesole G,Petrovsky N,Pillai R,Pontius JU,Qi D,Ramachandran S,Ravasi T,Reed JC,Reed DJ,Reid J,Ring BZ,Ringwald M,Sandelin A,Schneider C,Semple CA,Setou M,Shimada K,Sultana R,Takenaka Y,Taylor MS,Teasdale RD,Tomita M,Verardo R,Wagner L,Wahlestedt C,Wang Y,Watanabe Y,Wells C,Wilming LG,Wynshaw-Boris A,Yanagisawa M,Yang I,Yang L,Yuan Z,Zavolan M,Zhu Y,Zimmer A,Carninci P,Hayatsu N,Hirozane-Kishikawa T,Konno H,Nakamura M,Sakazume N,Sato K,Shiraki T,Waki K,Kawai J,Aizawa K,Arakawa T,Fukuda S,Hara A,Hashizume W,Imotani K,Ishii Y,Itoh M,Kagawa I,Miyazaki A,Sakai K,Sasaki D,Shibata K,Shinagawa A,Yasunishi A,Yoshino M,Waterston R,Lander ES,Rogers J,Birney E,Hayashizaki Y, , Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002();420(6915):563-73 PUBMED
John RM,Aparicio SA,Ainscough JF,Arney KL,Khosla S,Hawker K,Hilton KJ,Barton SC,Surani MA Imprinted expression of neuronatin from modified BAC transgenes reveals regulation by distinct and distant enhancers. Developmental biology. 2001();236(2):387-99 PUBMED
Kawai J,Shinagawa A,Shibata K,Yoshino M,Itoh M,Ishii Y,Arakawa T,Hara A,Fukunishi Y,Konno H,Adachi J,Fukuda S,Aizawa K,Izawa M,Nishi K,Kiyosawa H,Kondo S,Yamanaka I,Saito T,Okazaki Y,Gojobori T,Bono H,Kasukawa T,Saito R,Kadota K,Matsuda H,Ashburner M,Batalov S,Casavant T,Fleischmann W,Gaasterland T,Gissi C,King B,Kochiwa H,Kuehl P,Lewis S,Matsuo Y,Nikaido I,Pesole G,Quackenbush J,Schriml LM,Staubli F,Suzuki R,Tomita M,Wagner L,Washio T,Sakai K,Okido T,Furuno M,Aono H,Baldarelli R,Barsh G,Blake J,Boffelli D,Bojunga N,Carninci P,de Bonaldo MF,Brownstein MJ,Bult C,Fletcher C,Fujita M,Gariboldi M,Gustincich S,Hill D,Hofmann M,Hume DA,Kamiya M,Lee NH,Lyons P,Marchionni L,Mashima J,Mazzarelli J,Mombaerts P,Nordone P,Ring B,Ringwald M,Rodriguez I,Sakamoto N,Sasaki H,Sato K,Schönbach C,Seya T,Shibata Y,Storch KF,Suzuki H,Toyo-oka K,Wang KH,Weitz C,Whittaker C,Wilming L,Wynshaw-Boris A,Yoshida K,Hasegawa Y,Kawaji H,Kohtsuki S,Hayashizaki Y, Functional annotation of a full-length mouse cDNA collection. Nature. 2001();409(6821):685-90 PUBMED
Péterfy M,Phan J,Xu P,Reue K Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. Nature genetics. 2001();27(1):121-4 PUBMED
Kinoh H,Hayashita H,Kajita M,Okada A,Seiki M Assignment of the genes for membrane-type-4 matrix metalloproteinase (Mmp17, MMP17) to mouse chromosome 5, human chromosome band 12q24.3 and membrane-type-5 matrix metalloproteinase (Mmp24, MMP24) to mouse chromosome 2 and human chromosome band 20q11.2-->q12, respectively, by radiation hybrid and in situ hybridization. Cytogenetics and cell genetics. 1999();87(1-2):97-8 PUBMED
Kelsey G,Bodle D,Miller HJ,Beechey CV,Coombes C,Peters J,Williamson CM Identification of imprinted loci by methylation-sensitive representational difference analysis: application to mouse distal chromosome 2. Genomics. 1999();62(2):129-38 PUBMED
Williamson CM,Beechey CV,Ball ST,Dutton ER,Cattanach BM,Tease C,Ishino F,Peters J Localisation of the imprinted gene neuronatin, Nnat, confirms and refines the location of a second imprinting region on mouse chromosome 2. Cytogenetics and cell genetics. 1998();81(1):73-8 PUBMED
Kikyo N,Williamson CM,John RM,Barton SC,Beechey CV,Ball ST,Cattanach BM,Surani MA,Peters J Genetic and functional analysis of neuronatin in mice with maternal or paternal duplication of distal Chr 2. Developmental biology. 1997();190(1):66-77 PUBMED
Kagitani F,Kuroiwa Y,Wakana S,Shiroishi T,Miyoshi N,Kobayashi S,Nishida M,Kohda T,Kaneko-Ishino T,Ishino F Peg5/Neuronatin is an imprinted gene located on sub-distal chromosome 2 in the mouse. Nucleic acids research. 1997();25(17):3428-32 PUBMED
Sornson MW,Wu W,Dasen JS,Flynn SE,Norman DJ,O'Connell SM,Gukovsky I,Carrière C,Ryan AK,Miller AP,Zuo L,Gleiberman AS,Andersen B,Beamer WG,Rosenfeld MG Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism. Nature. 1996();384(6607):327-33 PUBMED
Wijnholds J,Chowdhury K,Wehr R,Gruss P Segment-specific expression of the neuronatin gene during early hindbrain development. Developmental biology. 1995();171(1):73-84 PUBMED

Uniparental Duplication	ProxBkpt	DisBkpt	Effects
MatDp(dist2)	T26H	T2Wa	decreased cerebellar folding
Region References
Williamson CM,Beechey CV,Ball ST,Dutton ER,Cattanach BM,Tease C,Ishino F,Peters J Localisation of the imprinted gene neuronatin, Nnat, confirms and refines the location of a second imprinting region on mouse chromosome 2. Cytogenetics and cell genetics. 1998();81(1):73-8 PUBMED
Searle AG,Beechey CV Complementation studies with mouse translocations. Cytogenetics and cell genetics. 1978();20(1-6):282-303 PUBMED
Cattanach BM,Kirk M Differential activity of maternally and paternally derived chromosome regions in mice. Nature. ();315(6019):496-8 PUBMED
Williamson CM,Schofield J,Dutton ER,Seymour A,Beechey CV,Edwards YH,Peters J Glomerular-specific imprinting of the mouse gsalpha gene: how does this relate to hormone resistance in albright hereditary osteodystrophy? Genomics. 1996();36(2):280-7 PUBMED
Kikyo N,Williamson CM,John RM,Barton SC,Beechey CV,Ball ST,Cattanach BM,Surani MA,Peters J Genetic and functional analysis of neuronatin in mice with maternal or paternal duplication of distal Chr 2. Developmental biology. 1997();190(1):66-77 PUBMED
Kagitani F,Kuroiwa Y,Wakana S,Shiroishi T,Miyoshi N,Kobayashi S,Nishida M,Kohda T,Kaneko-Ishino T,Ishino F Peg5/Neuronatin is an imprinted gene located on sub-distal chromosome 2 in the mouse. Nucleic acids research. 1997();25(17):3428-32 PUBMED
Williamson CM,Beechey CV,Papworth D,Wroe SF,Wells CA,Cobb L,Peters J Imprinting of distal mouse chromosome 2 is associated with phenotypic anomalies in utero. Genetical research. 1998();72(3):255-65 PUBMED
Cattanach BM,Beechey CV,Peters J Interactions between imprinting effects in the mouse. Genetics. 2004();168(1):397-413 PUBMED
Cattanach BM,Beechey CV,Peters J Interactions between imprinting effects: summary and review. Cytogenetic and genome research. 2006();113(1-4):17-23 PUBMED