| Imprinting Loci | Chromosome | Chromosomal Region | Expressed parental allele: maternal (M)/ paternal (P) | Name | ||
|---|---|---|---|---|---|---|
| Nespas | 2 | dist 2 | P | neuroendocrine secretory protein antisense | ||
| Gene Synonyms | ||||||
| Gnas-as | ||||||
| Gene References | ||||||
| Williamson CM,Turner MD,Ball ST,Nottingham WT,Glenister P,Fray M,Tymowska-Lalanne Z,Plagge A,Powles-Glover N,Kelsey G,Maconochie M,Peters J Identification of an imprinting control region affecting the expression of all transcripts in the Gnas cluster. Nature genetics. 2006();38(3):350-5 PUBMED | ||||||
| Carninci P,Kasukawa T,Katayama S,Gough J,Frith MC,Maeda N,Oyama R,Ravasi T,Lenhard B,Wells C,Kodzius R,Shimokawa K,Bajic VB,Brenner SE,Batalov S,Forrest AR,Zavolan M,Davis MJ,Wilming LG,Aidinis V,Allen JE,Ambesi-Impiombato A,Apweiler R,Aturaliya RN,Bailey TL,Bansal M,Baxter L,Beisel KW,Bersano T,Bono H,Chalk AM,Chiu KP,Choudhary V,Christoffels A,Clutterbuck DR,Crowe ML,Dalla E,Dalrymple BP,de Bono B,Della Gatta G,di Bernardo D,Down T,Engstrom P,Fagiolini M,Faulkner G,Fletcher CF,Fukushima T,Furuno M,Futaki S,Gariboldi M,Georgii-Hemming P,Gingeras TR,Gojobori T,Green RE,Gustincich S,Harbers M,Hayashi Y,Hensch TK,Hirokawa N,Hill D,Huminiecki L,Iacono M,Ikeo K,Iwama A,Ishikawa T,Jakt M,Kanapin A,Katoh M,Kawasawa Y,Kelso J,Kitamura H,Kitano H,Kollias G,Krishnan SP,Kruger A,Kummerfeld SK,Kurochkin IV,Lareau LF,Lazarevic D,Lipovich L,Liu J,Liuni S,McWilliam S,Madan Babu M,Madera M,Marchionni L,Matsuda H,Matsuzawa S,Miki H,Mignone F,Miyake S,Morris K,Mottagui-Tabar S,Mulder N,Nakano N,Nakauchi H,Ng P,Nilsson R,Nishiguchi S,Nishikawa S,Nori F,Ohara O,Okazaki Y,Orlando V,Pang KC,Pavan WJ,Pavesi G,Pesole G,Petrovsky N,Piazza S,Reed J,Reid JF,Ring BZ,Ringwald M,Rost B,Ruan Y,Salzberg SL,Sandelin A,Schneider C,Schönbach C,Sekiguchi K,Semple CA,Seno S,Sessa L,Sheng Y,Shibata Y,Shimada H,Shimada K,Silva D,Sinclair B,Sperling S,Stupka E,Sugiura K,Sultana R,Takenaka Y,Taki K,Tammoja K,Tan SL,Tang S,Taylor MS,Tegner J,Teichmann SA,Ueda HR,van Nimwegen E,Verardo R,Wei CL,Yagi K,Yamanishi H,Zabarovsky E,Zhu S,Zimmer A,Hide W,Bult C,Grimmond SM,Teasdale RD,Liu ET,Brusic V,Quackenbush J,Wahlestedt C,Mattick JS,Hume DA,Kai C,Sasaki D,Tomaru Y,Fukuda S,Kanamori-Katayama M,Suzuki M,Aoki J,Arakawa T,Iida J,Imamura K,Itoh M,Kato T,Kawaji H,Kawagashira N,Kawashima T,Kojima M,Kondo S,Konno H,Nakano K,Ninomiya N,Nishio T,Okada M,Plessy C,Shibata K,Shiraki T,Suzuki S,Tagami M,Waki K,Watahiki A,Okamura-Oho Y,Suzuki H,Kawai J,Hayashizaki Y, , The transcriptional landscape of the mammalian genome. Science (New York, N.Y.). 2005();309(5740):1559-63 PUBMED | ||||||
| Williamson CM,Skinner JA,Kelsey G,Peters J Alternative non-coding splice variants of Nespas, an imprinted gene antisense to Nesp in the Gnas imprinting cluster. Mammalian genome : official journal of the International Mammalian Genome Society. 2002();13(2):74-9 PUBMED | ||||||
| Ball ST,Williamson CM,Hayes C,Hacker T,Peters J The spatial and temporal expression pattern of Nesp and its antisense Nespas, in mid-gestation mouse embryos. Mechanisms of development. 2001();100(1):79-81 PUBMED | ||||||
| Li T,Vu TH,Zeng ZL,Nguyen BT,Hayward BE,Bonthron DT,Hu JF,Hoffman AR Tissue-specific expression of antisense and sense transcripts at the imprinted Gnas locus. Genomics. 2000();69(3):295-304 PUBMED | ||||||
| Wroe SF,Kelsey G,Skinner JA,Bodle D,Ball ST,Beechey CV,Peters J,Williamson CM An imprinted transcript, antisense to Nesp, adds complexity to the cluster of imprinted genes at the mouse Gnas locus. Proceedings of the National Academy of Sciences of the United States of America. 2000();97(7):3342-6 PUBMED | ||||||
| Uniparental Duplication | ProxBkpt | DisBkpt | Effects | |||
|---|---|---|---|---|---|---|
| MatDp(dist2) | T2Wa | T28H | Hypoactive, lethal | |||
| PatDp(dist2) | T2Wa | T28H | Hyperactive, oedematous, lethal | |||
| Region References | ||||||
| Kikyo N,Williamson CM,John RM,Barton SC,Beechey CV,Ball ST,Cattanach BM,Surani MA,Peters J Genetic and functional analysis of neuronatin in mice with maternal or paternal duplication of distal Chr 2. Developmental biology. 1997();190(1):66-77 PUBMED | ||||||
| Searle AG,Beechey CV Complementation studies with mouse translocations. Cytogenetics and cell genetics. 1978();20(1-6):282-303 PUBMED | ||||||
| Cattanach BM,Kirk M Differential activity of maternally and paternally derived chromosome regions in mice. Nature. ();315(6019):496-8 PUBMED | ||||||
| Williamson CM,Schofield J,Dutton ER,Seymour A,Beechey CV,Edwards YH,Peters J Glomerular-specific imprinting of the mouse gsalpha gene: how does this relate to hormone resistance in albright hereditary osteodystrophy? Genomics. 1996();36(2):280-7 PUBMED | ||||||
| Kagitani F,Kuroiwa Y,Wakana S,Shiroishi T,Miyoshi N,Kobayashi S,Nishida M,Kohda T,Kaneko-Ishino T,Ishino F Peg5/Neuronatin is an imprinted gene located on sub-distal chromosome 2 in the mouse. Nucleic acids research. 1997();25(17):3428-32 PUBMED | ||||||
| Williamson CM,Beechey CV,Ball ST,Dutton ER,Cattanach BM,Tease C,Ishino F,Peters J Localisation of the imprinted gene neuronatin, Nnat, confirms and refines the location of a second imprinting region on mouse chromosome 2. Cytogenetics and cell genetics. 1998();81(1):73-8 PUBMED | ||||||
| Williamson CM,Beechey CV,Papworth D,Wroe SF,Wells CA,Cobb L,Peters J Imprinting of distal mouse chromosome 2 is associated with phenotypic anomalies in utero. Genetical research. 1998();72(3):255-65 PUBMED | ||||||
| Cattanach BM,Beechey CV,Peters J Interactions between imprinting effects in the mouse. Genetics. 2004();168(1):397-413 PUBMED | ||||||
| Cattanach BM,Beechey CV,Peters J Interactions between imprinting effects: summary and review. Cytogenetic and genome research. 2006();113(1-4):17-23 PUBMED | ||||||
| Allele Symbol | Allele Name | MGI ID | ENSEMBL | REFSEQ | |
|---|---|---|---|---|---|
| Nespas<tm1Jop> | targeted mutation 1, Jo Peters | MGI:3621477 | ENSEMBL | ||
