Imprinting LociChromosomeChromosomal RegionExpressed parental allele: maternal (M)/ paternal (P)Name
Gnas 2dist 2MGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
Gene Synonyms
P1,P2,P3,Gsa,Nesp,Gnas1,Nespl,PHP1A,PHP1B,Gnasxl,Nesp55,Oedsml,Gs alpha,Gs-alpha,XLalphas,XLalphas,G alpha s,neuroendocrine-specific Golgi protein p55 isoform 1
Gene References
Chen M,Wang J,Dickerson KE,Kelleher J,Xie T,Gupta D,Lai EW,Pacak K,Gavrilova O,Weinstein LS Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation. Cell metabolism. 2009();9(6):548-55 PUBMED
Adams GB,Alley IR,Chung UI,Chabner KT,Jeanson NT,Lo Celso C,Marsters ES,Chen M,Weinstein LS,Lin CP,Kronenberg HM,Scadden DT Haematopoietic stem cells depend on Galpha(s)-mediated signalling to engraft bone marrow. Nature. 2009();459(7243):103-7 PUBMED
Chotalia M,Smallwood SA,Ruf N,Dawson C,Lucifero D,Frontera M,James K,Dean W,Kelsey G Transcription is required for establishment of germline methylation marks at imprinted genes. Genes & development. 2009();23(1):105-17 PUBMED
Wu JY,Purton LE,Rodda SJ,Chen M,Weinstein LS,McMahon AP,Scadden DT,Kronenberg HM Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways. Proceedings of the National Academy of Sciences of the United States of America. 2008();105(44):16976-81 PUBMED
Feng HZ,Chen M,Weinstein LS,Jin JP Removal of the N-terminal extension of cardiac troponin I as a functional compensation for impaired myocardial beta-adrenergic signaling. The Journal of biological chemistry. 2008();283(48):33384-93 PUBMED
Xie T,Chen M,Gavrilova O,Lai EW,Liu J,Weinstein LS Severe obesity and insulin resistance due to deletion of the maternal Gsalpha allele is reversed by paternal deletion of the Gsalpha imprint control region. Endocrinology. 2008();149(5):2443-50 PUBMED
Xie T,Chen M,Zhang QH,Ma Z,Weinstein LS Beta cell-specific deficiency of the stimulatory G protein alpha-subunit Gsalpha leads to reduced beta cell mass and insulin-deficient diabetes. Proceedings of the National Academy of Sciences of the United States of America. 2007();104(49):19601-6 PUBMED
Ulucan C,Wang X,Baljinnyam E,Bai Y,Okumura S,Sato M,Minamisawa S,Hirotani S,Ishikawa Y Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy. American journal of physiology. Heart and circulatory physiology. 2007();293(3):H1662-72 PUBMED
Rashid AJ,So CH,Kong MM,Furtak T,El-Ghundi M,Cheng R,O'Dowd BF,George SR D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum. Proceedings of the National Academy of Sciences of the United States of America. 2007();104(2):654-9 PUBMED
Show 87 more Gene References below
Uniparental DuplicationProxBkptDisBkptEffects
MatDp(dist2)T2WaT28HHypoactive, lethal
PatDp(dist2)T2WaT28HHyperactive, oedematous, lethal
Region References
Kikyo N,Williamson CM,John RM,Barton SC,Beechey CV,Ball ST,Cattanach BM,Surani MA,Peters J Genetic and functional analysis of neuronatin in mice with maternal or paternal duplication of distal Chr 2. Developmental biology. 1997();190(1):66-77 PUBMED
Searle AG,Beechey CV Complementation studies with mouse translocations. Cytogenetics and cell genetics. 1978();20(1-6):282-303 PUBMED
Cattanach BM,Kirk M Differential activity of maternally and paternally derived chromosome regions in mice. Nature. ();315(6019):496-8 PUBMED
Williamson CM,Schofield J,Dutton ER,Seymour A,Beechey CV,Edwards YH,Peters J Glomerular-specific imprinting of the mouse gsalpha gene: how does this relate to hormone resistance in albright hereditary osteodystrophy? Genomics. 1996();36(2):280-7 PUBMED
Kagitani F,Kuroiwa Y,Wakana S,Shiroishi T,Miyoshi N,Kobayashi S,Nishida M,Kohda T,Kaneko-Ishino T,Ishino F Peg5/Neuronatin is an imprinted gene located on sub-distal chromosome 2 in the mouse. Nucleic acids research. 1997();25(17):3428-32 PUBMED
Williamson CM,Beechey CV,Ball ST,Dutton ER,Cattanach BM,Tease C,Ishino F,Peters J Localisation of the imprinted gene neuronatin, Nnat, confirms and refines the location of a second imprinting region on mouse chromosome 2. Cytogenetics and cell genetics. 1998();81(1):73-8 PUBMED
Williamson CM,Beechey CV,Papworth D,Wroe SF,Wells CA,Cobb L,Peters J Imprinting of distal mouse chromosome 2 is associated with phenotypic anomalies in utero. Genetical research. 1998();72(3):255-65 PUBMED
Cattanach BM,Beechey CV,Peters J Interactions between imprinting effects in the mouse. Genetics. 2004();168(1):397-413 PUBMED
Cattanach BM,Beechey CV,Peters J Interactions between imprinting effects: summary and review. Cytogenetic and genome research. 2006();113(1-4):17-23 PUBMED
Allele SymbolAllele NameMGI IDENSEMBLREFSEQ
Gnas<tm1Lsw>targeted mutation 1, Lee S WeinsteinMGI:2152743ENSEMBLNM_019690
Gnas<tm1Gwa>targeted mutation 1, Gary WandMGI:2152744ENSEMBLNM_019690
Gnas<Oedsml-pat>oedematous-small, paternalMGI:2183306ENSEMBLNM_019690
Gnas<Oedsml>oedematous-smallMGI:2183318ENSEMBLNM_019690
Gnas<tm2Lsw>targeted mutation 2, Lee S WeinsteinMGI:3043359ENSEMBLNM_019690
Gnas<tm3Lsw>targeted mutation 3, Lee S WeinsteinMGI:3043361ENSEMBLNM_019690
Gnas<tm2.1Lsw>targeted mutation 2.1, Lee S WeinsteinMGI:3043369ENSEMBLNM_019690
Gnas<tm1Kel>targeted mutation 1, Gavin KelseyMGI:3050783ENSEMBLNM_019690
Gnas<tm1Jop-mat>targeted mutation 1, Jo Peters, maternalMGI:3050793ENSEMBLNM_019690
Gnas<tm1Jop>targeted mutation 1, Jo PetersMGI:3050794ENSEMBLNM_019690
Gnas<tm1Kel-mat>targeted mutation 1, Gavin Kelsey, maternalMGI:3050802ENSEMBLNM_019690
Gnas<tm2Kel>targeted mutation 2, Gavin KelseyMGI:3579575ENSEMBLNM_019690
Gnas<tm4Lsw>targeted mutation 4, Lee S WeinsteinMGI:3582306ENSEMBLNM_019690
Gnas<tm5Lsw>targeted mutation 5, Lee S WeinsteinMGI:3609165ENSEMBLNM_019690
Gnas<tm3Kel>targeted mutation 3, Gavin KelseyMGI:3830998ENSEMBLNM_019690