AllEmbryo onlySperm onlyCre onlyTet only
Strain NameGene/Allele SymbolChrPhenotypeAvailability
C3H101H-Eif3c<Xs>/H Eif3c<Xs> 7Extra-toes spotting.Order From EMMA
(beta)-globin (mu)MT
<-/-> 		Ighm<tm1Cgn> 12(mu)MT<-/-> produces IgM H-chains.Order
B6.129-Kcnj16<tm1Pes
s>/H 		Kcnj16<tm1Pess> 11Disrupted Kir 5.1 Potassium Channel. Phenotype not known at this point.Order
Kcnj16 11
101/H A<w> 2Inbred strain.Order
Gpi1<a> 7
Hbb<d> 7
Xic<a> X
102/H Wild type, inbred strain.Order
101/H-Tbob/H Tbob Heterozygotes head-bob, circle and walk backwards.Order
129-Mta1<tm1a(EUCOMM
)Wtsi>/WtsiH 		Mta1 12Potential EUMODIC data in the Europhenome database.Order From EMMA
129S9/SvEvH-Nodal<tm
1Rob>/H 		Nodal<tm1Rob> 10Heterozygote viable. Homozygote early developmental lethal (does not gastrulate).Order
129P2/OlaHsdH The mice have yellow coats and late onset severe vacuolation in brain (700+ days).Order
129P2/OlaHsdH-Prnp<t
m2Edin>/H 		Prnp<tm2Edin> 2No expression of the Prnp gene. Abnormalities in synaptic transmission, circadian rhythm and sleep. Increased susceptability to oxidative stress and copper toxicity. Cellular phenotypes in T cell activation.Order From EMMA
129S8/SvEv-Gpi1<c>/N
imrH 		A<w> 2Inbred strain.Order
Tyr<c> 7
Tyr<c-ch> 7
129S9/SvEvH Wildtype.Order
129.Cg-Tg(Hbb-b)83Cl
o/WsH 		Tg(Hbb-b1)83Clo Reiterated transgene is detectable by DNA in situ hybridisation.Order
129.Cg-Pax6<Sey> Tg(
Hbb-b1)83Clo/WsH 		Pax6<Sey> 2Reiterated transgene is detectable by DNA in situ hybridisation.Order From EMMA
Tg(Hbb-b1)83Clo
129S9/SvEvH.B6-a/H a 2Black coat colour. The non-agouti locus from C57BL/6J has been bred to congenicity on a 129S9/SvEvH background. This stock is homozygous for non-agouti (a/a).Order From EMMA
129-Fgfr3<tm1.1Aomw>
/Aomw 		Fgfr3<tm1.1Aomw> 5All homozygous males, some homozygous females and some heterozygous males develop an abnormal skull phenotype sometimes with malocclusion, and may be smaller in size. The phenotype is not fully penetrant. Refer to publication for further information: PMID:19086028. Order From EMMA
B6NTac;B6N-2310022B0
5Rik<tm1a(EUCOMM)Hmgu>/H 		2310022B05Rik<tm1a(E
UCOMM)Hmgu> 		8Potential EUMODIC data in the Europhenome database. Order From EMMA
Xpo4 Xpo4 14Phenotypically normal.Order From EMMA
A/JH Tyrp1<b> 4Inbred strain.Order
Tyr<c> 7
a 2
A.129P2-Nat2<tm1Esim
>/H 		Nat2<tm1Esim> 8No overt phenotype.Order From EMMA
C3H101H-a<13H>/H a<13H> 2(hair - colour) non-agouti-13-Harwell. a<13H>/a has umbrous appearance, A<13H>/a<13H> is dark with black pinna hairs.Order
C3H;101H-a<16H>/a<l>
/H 		a<16H> 2(coat colour) black back and pinna hairs and agouti belly and flanks. Homozygotes die prenatally.Order
a<l> 2
C3H101H-a<17H>/H a<17H> 2(hair - colour) non-agouti-17-Harwell. a<17H>/a looks like aa; a<17H>/a<17H> looks like aa but with dark ears.Order
C3H101H-a<18H>/H a<18H> 2Homozygotes are non-agouti with very dark pinna hairs. A/a<18H> looks wild-type. a/a<18H> look umbrous i.e. non-agouti with agouti hairs along side of body and on the belly. Order From EMMA
C3H101H-a<19H>/H a<19H> 2(hair - colour) non-agouti-19-Harwell. a<19H>/a looks like aa, a<19H>/a<19H> has black pinna hairs.Order
C3H101H-a<20H>/H a<20H> 2(hair - colour) non-agouti-20-Harwell. Compound heterozygotes (a<20H>/a) have umbrous appearance. Homozygotes have black ears and tail, the coat being more agouti than a<20H>/a.Order
C3H101H-a<da>/H a<da> 2(hair - colour) Non-agouti with dark agouti belly.Order
C3H;101H-a<t-2H>/H a<t-2H> 2(hair - colour) black and tan.Order
C3H101HF1 x STOCK-a<
tl>/H 		Resembles a<t> but there is no clear dividing line between black on the back and tan on the belly. Additionally, the tan colour is present on face spreading above the eyes. Breeding data indicate that viability of homozygotes is normal. Both homozygous females and males are fertile. Compound heterozygotes a<t>/a<tl> look like a<tl>/a<tl>. Aa<tl> have pale coloured belly fur.Order
C3H101H-a<u>/H a<u> 2(hair - colour) agouti-umbrous.Order
STOCK A<y>/a Tyrp1<b
>/H 		A<y> 2(hair - colour, eye - colour, size - obesity, sterile) heterozygotes all the hair pigment is yellow and the eyes are black; they usually become obese and sterile after the first few months. Homoygotes die pre-implantation or a short time thereafter.GVSLM3: 1,23-24.Order
Tyrp1<b> 4
Col3 alpha 1 delta Col3a1<m1Lsmi> 1Death between 4-8 weeks post-partum from aortic rupture.Order
B6Dnk;B6N-Abcd4<tm1a
(EUCOMM)Hmgu>/H 		Abcd4<tm1a(EUCOMM)Hm
gu> 		12Potential EUMODIC data in the Europhenome database.Order From EMMA
129S9/SvEvH-Ablim1<t
m1H>/H 		Ablim1 19Order
B6;129-Ablim1<tm1H>/
H 		Ablim1 19Order
B6NTac;B6N-Acsbg2<tm
1a(EUCOMM)Wtsi>/H 		Acsbg2<tm1a(EUCOMM)W
tsi> 		17Potential EUMODIC data in the Europhenome database.Order From EMMA
B6.Cg-Tg(ACTFLPe)920
5Dym/H 		Tg(ACTFLPe)9205Dym No overt phenotype. Order From EMMA
C3H101H-Ada<b>/H Ada<b> 2Ada<b> determines a slow electrophoretic variant and was found in wild mice on the Orknay island of Eday. (From GVSLM).Order
C3H101H-Ada<c>/H Order
B6;129P2-Adamts1<tm1
Dgen>/H 		Adamts1<tm1Dgen> 16No overt phenotype.Order From EMMA
B6;129P2-Adamts2<tm1
Dgen>/H 		Adamts2<tm1Dgen> 11No overt phenotype.Order From EMMA
B6;129P2-Adcyap1r1<t
m1Dgen>/H 		Adcyap1r1<tm1Dgen> 6No visible phenotype.Order From EMMA
129P2/OlaHsd-Fbxl3<G
t(CB0226)Wtsi>/H 		Fbxl3 14Order
C57BL/6NTac-Afmid<tm
1a(EUCOMM)Wtsi>/H 		Afmid<tm1a(EUCOMM)Wt
si> 		11Potential IMPC data in the Mousephenotype.org database.Order From EMMA
C3.C-Fbxl3<Afh>/H Fbxl3<Afh> 14Identified in circadian rhythm screen. Mutants have a long circadian period 24.23hr (a) and 24.12hr (b).Order From EMMA
Akt2<tm1Wtsi> Akt2 7None.Order
Tg(Thy1-Dusp6)1Ked Order
C57BL-Tg(Gabra6-Bmi1
)1004Mro/H 		Phenotype is currently being characterised.Order From EMMA
Ananisi An ENU-induced mutation causing heritable anti-nuclear antibodies with variable penetrance by 12-16 weeks of age. Lymphocyte populations appear grossly normal by flow cytometry. Order From EMMA
Anaya An ENU-induced mutation causing heritable anti-nuclear antibodies with variable penetrance by 12-16 weeks of age. Lymphocyte populations appear grossly normal by flow cytometry. Order From EMMA
Andromeda An ENU-induced mutation causing heritable anti-nuclear antibodies with variable penetrance by 12-16 weeks of age. Lymphocyte populations appear grossly normal by flow cytometry. Order From EMMA
Tg(Thy1-Dusp6)2Ked Order
Angelina Increased marginal zone size with age and activated peripheral CD8 T cells.Order From EMMA
Anb Anb Heterozygotes have polydactyly of the hind limbs. Homozygotes have polydactyly of all four limbs.Order
Tg(Thy1-Dusp6)3Ked Order
Antonia An ENU-induced mutation causing heritable anti-nuclear antibodies and variable proliferative and membranous glomerulonephritis with partial dominant phenotype and penetrance by 12-16 weeks of age. Lymphocyte populations appear grossly normal by flow cytometry and immunoglobulin levels.Order From EMMA
C57BL/6J-Apc<Min>/5H Apc<Min> 18Mice develop life-shortening intestinal polyposis.Order From EMMA
C57BL/6J-Apc<Min>/2H Apc<Min> 18(adenoma - anaemia) multiple intestinal neoplasia.Order From EMMA
B6;129-Apoe<tm1Bres>
Lgals3<tm1Ftl>/CljH 		Lgals3<tm1Ftl> 14Order From EMMA
Apoe<tm1Bres> 7
129(B6)-Serpine1<tm1
Mlg> Apoe<tm1Bres>/CljH[cc] 		Apoe<tm1Bres> 7Shortened life span.Order From EMMA
Serpine1<tm1Mlg> 5
129(B6)-Apoe<tm1Bres
> Plg<tm1Jld>/CljH[cc] 		Apoe<tm1Bres> 7Rectal prolapse. Shortened life span in homozygotes.Order From EMMA
Plg<tm1Jld> 17
129(B6)-Apoe<tm1Bres
> Plat<tm1Mlg>/CljH[cc] 		Apoe<tm1Bres> 7None. Order From EMMA
Plat<tm1Mlg> 8
129.Cg-Tgm2<tm1Gml>
Apoe<tm1Bres>/CljH[cc] 		Apoe<tm1Bres> 7None.Order From EMMA
Tgm2<tm1Gml> 2
STOCK Ar<Tfm>/H Eda<Ta-33H> XHemizygous males are outwardly female in appearance but internally they have testes.Order
Ar<Tfm> X
Atp7a<Mo-blo> X
C;129-Araf<tm1Mmc>/H Araf<tm1Mmc> XAraf knockout mice litters are approximately one-third to half the size of their wildtype siblings from day 3 to pre weaning and so do not normally reach breeding age. However, placing them on supplementary diet or removing competition from other siblings, allows some to survive post weaning. Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-raf protein Kinase gene.Order
B6;129-Araf<tm1Mmc>/
H 		Araf<tm1Mmc> XX-linked gene.Order
Araf:Beta-geo Order
STOCK Araf<tm1Mmc>/H Araf<tm1Mmc> XAraf knockout mice litters are approximately one-third to half the size of their wildtype siblings from day 3 to pre weaning and so do not normally reach breeding age. However, placing them on supplementary diet or removing competition from other siblings, allows some to survive post weaning. Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-raf protein Kinase gene.Order
B6;129S4-Rhog<tm1Tnr
>/H 		Rhog<tm1Tnr> 7Mild hyper reactivity of lymphocytes to antigen receptor engagement.Order From EMMA
STOCK Atp7a<Mo-10H>/
H 		Atp7a<Mo-10H> X(hair - colour) mottled. Typically, Atp7a<Mo-10H>/+ females have straight rather than curled vibrissae at birth and later exhibit a low level of grey patching of the fur. Hemizygous males have wavy vibrissae at birth and develop a near white coat; their gait is uncoordinated becoming progessively worse; they die before weaning. At birth there is a shortage of heterozygous females and hemizygous males suggesting some prenatal lethality.Order
C3H101H-Atp7a<Mo-11H
>/H 		Atp7a<Mo-11H> X(hair - colour) mottled. Typically heterozygous females have an obviously variegated coat. Hemizygous males have wavy vibrissae at birth and later develop a near white coat. They also have an uncoordinated gait which gets progressively worse; they die before weaning. Breeding data suggest post natal loss of a proportion of heterozygous females; most hemizygous males are lost prenatally.Order
STOCK Atp7a<Mo-12H>/
H 		Atp7a<Mo-12H> X(hair - colour) mottled. Typically Atp7a<Mo-12H>/+ have an extreme variegated coat. At birth their whiskers are noticeably curly. The more adversely affected have progressive loss of mobility and balance. Many show skeletal abnormalities. Viability is substantally reduced. Hemizygous males are lethal prenatally.Order
C3H101H-Atp7a<Mo-13H
>/H 		Atp7a<Mo-13H> X(hair - colour) mottled. Heterozygous females have a similar appearance to Atp7a<Mo-blo>/+ i.e. mildly affected - a proportion are mis-classified as wild-type; viability is good. Hemizygous males look like Atp7a<Mo-br>/Y, most dying between 2-3 weeks of age.Order
STOCK Atp7a<Mo-14H>/
H 		Atp7a<Mo-14H> X(hair - colour) mottled. Breeding data: indicate that hemizygous males are prenatal lethal; suggest that circa 25% of heterozygous females are lost prior to birth, but viability between birth and weaning is good. Mutation is probably a point mutation or a small deletion (see PMID:8672124).Order
STOCK Atp7a<Mo-17H>/
H 		Atp7a<Mo-17H> X(hair - colour) mottled. Mo-17H/Y die prior to birth. Breeding data suggest that on crosses to 3H1 males, there is some pre or perinatal loss of Mo-17H/+; viability to weaning is circa 60%. From crosses to C57BL/6J males, there is little or no loss of Mo-17H/+ at birth and viability to weaning is significantly increased.Order
C3H101HF1 x STOCK At
p7a<Mo-18H>T(7;15)9H/H 		Atp7a<Mo-18H> XAtp7a<Mo-18H>/+: mottled coat; can be identified at birth by whiskers: they are either curly or absent. Hemizygous males die in utero. The coat colour of females are typical Atp7a<Mo> but Atp7a<Mo-18H> has not been studied in depth. From outcrosses to C57BL/6J males, penetrance of the mutation is good and viability of heterozygous females to weaning is high.Order
C3H101HF1 x STOCK At
p7a<Mo-blo>/H 		Atp7a<Mo-blo> X(hair colour) blotchy. Heterozygous females have irregular patches of light coloured fur. Expression is poor at weaning but is complete by adulthood. Viability and fertility is normal. Hemizygous males and homozygous females are light all over with no blotching, are usually small. They occasionally have deformed hindlegs and have reduced viability, some are infertile. Vibrissae are kinked at birth but straight at weaning.Order
C3H101HF1 x STOCK At
p7a<Mo-ca>/H 		Atp7a<Mo-ca> X(hair colour) Mottled candy.Order
C3H101H-Atp7a<Mo-dp>
/H 		Atp7a<Mo-dp> X(hair - colour, gait, skeleton) mottled dappled.Order
C3H101H-Atp7a<Mo-spt
>/H 		Atp7a<Mo-spot> X(hair - colour) mottled spot.Order
C3H101H-Atp7a<Mo-to>
/H 		Atp7a<Mo-to> X(hair - colour) mottled tortoiseshell.Order
STOCK Atp7a<Mo-vbr>/
H 		Atp7a<Mo-vbr> X(hair - colour, viable brindled. Heterozygous females have a mottled coat of coloured and whitish hair in a pattern of somewhat transversely arranged stripes. Hemizygous males are white and have reduced viability and are sterile. They have aortic aneurysms, reduced breaking strength of skin and defective crosslinking of skin collagen and aortic elastin.Order
C3;CAnN-Pde6b<atrd1>
/H 		Pde6b<atrd1> 5Eyes-slow onset retinal degeneration.Order From EMMA
STOCK Pde6b<atrd2>/H Pde6b<atrd2> 5Slow onset retinal degeneration.Order From EMMA
Tyr<c> 7
Tyrp1<b> 4
C3H;C-Pde6b<atrd3>/H Pde6b<atrd3> 5Eyes- slow onset retinal degeneration.Order From EMMA
C3H;C-Pde6b<rd1-1H>/
H 		Pde6b<rd1-1H> 5Slow onset retinal degeneration.Order
C3;CAnN-Pde6b<rd1-2H
>/H 		Pde6b<rd1-2H> 5Slow onset retinal degeneration.Order From EMMA
C3;CAnN-Pde6b<rd1-3H
>/H 		Pde6b<rd1-3H> 5Slow onset retinal degeneration.Order From EMMA
C3;CAnN-Pde6b<rd1-4H
>/H 		Pde6b<rd1-4H> 5Slow onset retinal degeneration.Order From EMMA
B(Beta)DB<tm2Ked> Dtnb 12None observed. Order
B10.L-Slc11a1<r>/H Slc11a1<r> 1Order
B10ScSn.BXSB-(D1Mit3
-D1Mit320) Chr Y<BXSB/MpJ>/BjmjrH 		Enhanced autoantibody spectrum and titre.Order From EMMA
B10ScSn.BXSB-(D1Mit3
-D1Mit235) Chr Y<BXSB/MpJ>/BjmjrH 		Enhanced autoantibody spectrum and titre. Order From EMMA
B10ScSn.BXSB-(D1Mit1
23-D1Mit1000) Chr Y<BXSB/MpJ>/BjmjrH 		Enhanced autoantibody spectrum and titre. Glomerulonephritis susceptibility.Order From EMMA
B10ScSn.BXSB-(D1Mit2
35-D1Mit1000) Chr Y<BXSB/MpJ>/BjmjrH 		Glomerulonephritis susceptibility.Order From EMMA
B10ScSn.BXSB-(D1Mit3
03-D1Mit305) Chr Y<BXSB/MpJ>/BjmjrH 		Glomerulonephritis susceptibility.Order From EMMA
B10ScSn.BXSB-(D1Mit3
3-D1Mit223) Chr Y<BXSB/MpJ>/BjmjrH 		ANA, 75% mortality, enhanced autoantibody titre, severe glomerulonephritis.Order From EMMA
B6.CBA-TgN(HDexon1)6
1Gpb/H 		Tg(HDexon1)61Gpb Huntington's disease, tremors, weight loss, movement disorders, died on average at 7 months old.Order
B6.129-Igf1r<tm1.2Mh
z>/Orl 		Igf1r<tm1.2Mhz> 7Live longer; resistant to oxidative stress.Order
B6.Cg-Mir155<tm1.1Br
d>Tyr<c-Brd>/H 		Mir155<tm1.1Brd> 16No visible phenotype is associated with this mutation but the mice do exhibit reduced lung airway remodelling & deficient B-cell, T-cell & dendritic cell function. This mutation is on a C57BL/6<c-/c-> background and is albino in appearance. The BIC mice (EMMA ID EM:02231) have been backcrossed at least 5 times to C57BL/6, thus making them suitable for bone marrow transplantation, without rejection, to any C57BL/6 mice, regardless of coat color.Order From EMMA
Tyr<c-Brd> 7
B6129S8-Tc(Hsa21)1Ty
bEmcf/H 		Tc(HSA21)1TybEmcf This strain displays learning abnormalities, reduced long-term potentiation in the hippocampus, heart and brain developmental defects, craniofacial dysmorphology (this strain models human Down syndrome).Order From EMMA
B6;D2-Tg(Sycp1-cre)4
Min/J 		Tg(Sycp1-cre)4Min None given.Order
B6CBA-Tg(HDexon1)61G
pb/H 		Tg(HDexon1)61Gpb Model for Huntington's disease, tremors, weight loss, movement disorders, die on average at 7 months old.Order
B6.Cg-Dazl<tm1Hjc>/H
 		Dazl<tm1Hjc> 17Mice homozygous for this mutation in this background lack germ cells at birth in both sexes. Heterozygous mice show close to normal fertility.Order From EMMA
B6.Cg-Syce2<Gt(FHCRC
-GT-S8-7E1)Sor>/H 		Syce2<Gt(FHCRC-GT-S8
-7E1)Sor> 		8Mice homozygous for this mutation in this background can not progress to diplotene stages of meiosis and show a failure of synapsis. Heterozygous mice show close to normal fertility.Order From EMMA
B6NTac;B6N-Per2<tm1a
(EUCOMM)Hmgu>/H 		Per2<tm1a(EUCOMM)Hmg
u> 		1Potential EUMODIC data in the Europhenome database.Order From EMMA
C57BL/6NTac-2810408A
11Rik<tm1a(EUCOMM)Wtsi>/H 		2810408A11Rik<tm1a(E
UCOMM)Wtsi> 		11Potential EUMODIC data in the Europhenome database.Order From EMMA
C57BL/6NTac-Dnajc10<
tm1a(EUCOMM)Hmgu>/H 		Dnajc10<tm1a(EUCOMM)
Hmgu> 		2Potential EUMODIC data in the Europhenome database. Order From EMMA
C57BL/6NTac-Mapkbp1<
tm1a(EUCOMM)Hmgu>/H 		Mapkbp1<tm1a(EUCOMM)
Hmgu> 		2Potential EUMODIC data in the Europhenome database.Order From EMMA
B6Dnk;B6N-Tbc1d2b<tm
1a(EUCOMM)Hmgu>/H 		Tbc1d2b<tm1a(EUCOMM)
Hmgu> 		9Potential EUMODIC data in the Europhenome database.Order From EMMA
B6NTac;B6N-2310044H1
0Rik<tm1a(EUCOMM)Wtsi>/H 		Emc10<tm1a(EUCOMM)Wt
si> 		7Potential EUMODIC data in the Europhenome database.Order From EMMA
B6NTac;B6N-Asns<tm1a
(EUCOMM)/Wtsi>/H 		Asns<tm1a(EUCOMM)Wts
i> 		6Potential EUMODIC data in the Europhenome database.Order From EMMA
B6NTac;B6N-Gse1<tm1a
(EUCOMM)Wtsi>/H 		Gse1<tm1a(EUCOMM)Wts
i> 		8Potential EUMODIC data in the Europhenome database.Order From EMMA
Tg(RP23-439H2)2H Normal.Order
C57BL/6NTac-Bag3<tm1
a(EUCOMM)Hmgu>/H 		Bag3<tm1a(EUCOMM)Hmg
u> 		7Potential EUMODIC data in the Europhenome database.Order From EMMA
BALB/c Tyrp1<b> 4Albino.Order
Tyr<c> 7
BALB/cOla White coat colour.Order
C.Cg-Il1r1<tm1Imx>/N
ick 		Il1r1<tm1Imx> 1Order From EMMA
C.Cg-Il1rn<tm1Nick>/
Nick 		Il1rn<tm1Nick> 2Strain sporadically and independently develops rheumatoid-like arthritis, localised psoriasis-like lesions and patchy transmural destructive arteritis of the elastic vessels. Hygiene dependent (negative correlation). Different strain dependence of each disease. This strain, our SPF lab, 80% affected (each disease independently) at 200 days.Order From EMMA
CByIco.129S-Rag2<tm1
Fwa>/H 		Rag2<tm1Fwa> 2Chronic intestinal inflammation, colitis.Order From EMMA
CByIco.129-Rag2<tm1F
wa> Cd44<tm1Ugu>/H 		Cd44<tm1Ugu> 2Chronic intestinal inflammation, colitis.Order From EMMA
Rag2<tm1Fwa> 2
CByIco.129-Rag2<tm1F
wa> Cd44<tm2.1Ugu>/H 		Rag2<tm1Fwa> 2Mice are homozygous for both Rag-/- and CD44v10-/- knockouts. Rag2-/-, no mature T and B cells. CD44v10-/-, strongly reduced symptoms in autoimmune diseases. Used in mouse models of experimental colitis.Order From EMMA
Cd44 2
CByIco.129-Rag2<tm1F
wa> Cd44<tm1.1Ugu>/H 		Cd44<tm1.1Ugu> 2Rag2-/-: no mature T and B cells. CD44v6v7-/-: strongly reduced symptoms in autoimmune diseases.Order From EMMA
Rag2<tm1Fwa> 2
BALB/cPye Order
C3H101H-Bbn/H Bbn Affected animals are deaf and exhibit headbobbing and circling behaviour.Order From EMMA
Tyrp1<b> 4
Tyr<c> 7
Hbb<d4> 7
Hbb<d> 7
STOCK BC055324<tm1a(
EUCOMM)Hmgu>/H 		BC055324<tm1a(EUCOMM
)Hmgu> 		1Potential EUMODIC data in the Europhenome database.Order From EMMA
C57BL/6N-Bdh2<tm1a(E
UCOMM)Wtsi>/WtsiH 		Bdh2<tm1a(EUCOMM)Wts
i> 		3Potential EUMODIC data in the Europhenome database.Order From EMMA
C57BL/6N-Bdh2<tm1b(E
UCOMM)Wtsi>/WtsiH 		Tg(ACTB-cre)3Mrt Order
Tg(ACTB-cre)3Mrt UN
Bdh2 3
C57BL/6NTac-Tg(ACTB-
cre)3Mrt/H 		Tg(ACTB-cre)3Mrt Ubiquitous cre expressor. No overt phenotype.Order From EMMA
C3H101H-Bhd +/+ Pou3
f4<Slf>/H 		Bhd X(head - nose) broad-headed.Order
Pou3f4<Slf> X
Bhv11 Abnormal craniofacial features.Order From EMMA
STOCK Bhv26/H The alternation score suggest this line has a potential short term working memory deficit. Order From EMMA
C3H;C-Bhv31/H Bhv31 5High anxiety.Order From EMMA
Bhv31 5
C3;C-BHV32/H Hyperactivity.Order From EMMA
C3H;C-Bhv43/H Possible short-term working memory deficit indicated by reduced spontaneous alternation in the Y-maze. Order From EMMA
BALB/cAnN-Rgs18<m1H>
/H 		Rgs18<m1H> 1None apparent, in heterozygotes.Order From EMMA
Rgs18 1
C3H.C-Trpc3<Mwk>/H Trpc3<Mwk> 3Staggering, ataxic with limited movement in back legs. Heterozygotes are usually small.Order From EMMA
ABL Inbred strain.Order
C3H101HF1 x STOCK Fr
as1<bl> Fgf5<go>/H 		Fras1<bl> 5(eye, feet, kidney, skin) blebbed. Closely resembles my. Homozygotes usually have reduced eyes, many have clubbed feet, and one or both kidneys may be absent. Blebs under the skin are often still visible.Order From EMMA
Fgf5<go> 5
C57BL/6J-blst/H blst Spontaneous recessesive coat colour mutation - light grey coat colour. Order From EMMA
C57BL/6J-Btnt/H Btnt Tan coat colour on belly.Order From EMMA
Blatant2 Tan coat colour on belly.Order From EMMA
C3;C-Snap25<Bdr>/H Snap25<Bdr> 2Poor sight. Blind drunk. Small at weaning. SHIRPA anomalies including reduced or absent visual placing and staggering gait. Homozygotes have not been identified.Order From EMMA
C57BL/6J-Blite/H Blite White with non-agouti patches. Some patches reverting to non-agouti are visible in a small number of offspring. Timed matings of heterozygous stock can yield oedematous embryos.Order From EMMA
C57BL/6J-Blff/H Blff Heterozygotes have a fluffy coat, abnormal hair distribution and texture. Order
Blff UN
C3H101HF1 x STOCK a
Papss2<bm> Hps1<ep> Hps6<ru>/H 		Papss2<bm> 19(skeleton) dwarfism - cleft palate brachymorphic. Homozygotes have disproportionate dwarfing; overall length and length of long bones are reduced to about 3/4 of normal and bone width is very little affected. Homozygotes are recognised at about 5 days by their short domed skulls and short tails. Malocclusion occurs occasionally. Viability is good and both sexes are fertile.Order
Hps6<ru> 19
Hps1<ep> 19
BMD2 Low bone mineral density.Order
C3H101H-Bmp5<se-19H>
/H 		Bmp5<se-19H> 9Short-ear. Bmp5<se-19H>/Bmp5<se> looks like Bmp5<se>/Bmp5<se>. Bmp5<se-19H>/Bmp5<se-19H> has black pinna hairs.Order
Bmp5<se-20H> Bmp5<se-20H> 9Short-ear. Bmp5<se-20H>/Bmp5<se> look like Bmp5<se>/Bmp5<se>. Bmp5<se-20H>/Bmp5<se-20H> are lethal, probably pre-natally.Order
CD1;129-Bmp6<tm1Rob>
/H 		Bmp6<tm1Rob> 13Mice show no overt phenotype.Order From EMMA
STOCK Bmp7<tm2Rob>/H
 		Bmp7<tm2Rob> 2Homozygous embryonic lethal.Order From EMMA
STOCK Bmp7<tm1Rob>/H Bmp7<tm1Rob> 2This strain is a null allele of BMP7 generated by replacing the BMP7 coding sequence by a neomycin cassette. BMP7 is required in the metanephric mesenchyme of the developing kidney to support maintenance of this cell population during organogenesis. Homozygous lethal at birth due to kidney agenesis. Order From EMMA
C57BL/6NTac-Bmp7<tm1
a(EUCOMM)Hmgu>/H 		Bmp7<tm1a(EUCOMM)Hmg
u> 		2Potential EUMODIC data in the Europhenome database. Order From EMMA
Zic3<Bn>, Atp7a<Mo-b
r> 		Atp7a<Mo-br> X(coat colour) mottled brindled, Bent tail.Order
Zic3<Bn> X
C3H101H-Nsdhl<Bpa-1H
>/H 		Nsdhl<Bpa-1H> X(skin, size, tail ) bare patches.Order
C3H101H-Nsdhl<Bpa-3H
> 		Nsdhl<Bpa-3H> X(skin - skeleton) scarring on females at 4 days old. More females than males born and some have spine abnormalities. Bare patches are clearly visible at weaning.Order
C3H101H-Nsdhl<Bpa-4H
>/H 		Nsdhl<Bpa-4H> X(skin - skeleton) phenotype classed at 8 days but are barely visible at weaning. More females than males are born and they are prone to spinal abnormalities.Order
C3H101H-Nsdhl<Bpa-5H
>/H 		Nsdhl<Bpa-5H> X(skin - skeleton - size) phenotype classed at 8 days some are small at birth. More females than males born and they are prone to spinal abnormalities.Order
C3H101H-Nsdhl<Bpa-6H
> 		Nsdhl<Bpa-6H> X(skin) bare patches classed at 4 days and are clearly visible at weaning.Order
C3H101H-Nsdhl<Bpa-8H
>/H 		Nsdhl<Bpa-8H> XMale lethal. Females are classified at 8 days by scarring on the skin, small at weaning. The adult females are striped.Order From EMMA
C3H101H-Br/H Br 17(nose - mouth, kidneys - size) brachyrrhine. Heterozygotes have a much shortened snout classifiable at birth, and a deeper than usual median cleft in the upper lip. Kidneys are small at birth and, in a number of Br/+ mice dying in early maturity, were extremely pale with very few glomeruli. Heterozygotes are smaller than normal and there is a shortage of them at birth in outcrosses. Homozygotes have not been identified.Order
129-Brd7<tm2a(EUCOMM
)Wtsi>/WtsiH 		Brd7<tm2a(EUCOMM)Wts
i> 		8Potential EUMODIC data in the Europhenome database.Order From EMMA
B6Dnk;B6N-Bre<tm1a(E
UCOMM)Wtsi>/H 		Bre<tm1a(EUCOMM)Wtsi
> 		5Potential EUMODIC data in the Europhenome database.Order From EMMA
Brn3a Knockout Pou4f1 14Homozygote neonate lethality caused by lack of suckling due to defects in sensory and motor neurons.Order
Brn3b Knockout Pou4f2 8Homozygotes are blind due to failure of the retinal ganglia to develop.Order
B6Dnk;B6N-Brpf1<tm1a
(EUCOMM)Wtsi>/H 		Brpf1<tm1a(EUCOMM)Wt
si> 		6Potential EUMODIC data in the Europhenome database.Order From EMMA
C3H101H-Gsdma3<Bsk>/
H 		Gsdma3<Bsk> 11(skin, eyes) bareskin, corneal opacities.Order
STOCK Bstk/H Bstk (hair - colour) Affected individuals have a belly spot and light feet. By weaning, both female and male heterozygotes are on average about 15% lighter in weight than wild-type sibs. Assuming no loss of heterozygotes, penetrance of the belly streak phenotype is about 75% on a predominantly C3H/HeH background and more greatly reduced on a mixed genetic background. Intercrosses of heterozygotes failed to produce offspring with a more obviously severe phenotype at birth or weaning. Opening data (37 live embryos: 15 dead/moles) also strongly indicate that homozygotes are lethal and die by 14 dpc. Allelism test with Kitl<Sl-con> (MGI:1856163) showed that Bstk is not an allele of Kitl. Linkage tests with Gli3<Xt> (MGI:156275) and Krt71<Ca> (MGI:185590) showed no evidence of linkage.Order
Bstk UN
bv Srrm4<bv> 5Bronx Waltzer. Recessive mutant; hyperactivity, circling, headbobbing and deafness in the homozygote.Order
STOCK bv/H Srrm4<bv> 5Bronx Waltzer.Order From EMMA
C.D2-vil6 Order
C57BL/6NTac-C030046E
11Rik<tm1a(EUCOMM)Hmgu>/H 		C030046E11Rik<tm1a(E
UCOMM)Hmgu> 		19Potential EUMODIC data in the Europhenome databaseOrder From EMMA
C3Fe.CGr(Cg)-nr/JH nr 8Homozygotes are smaller in size and have hyperactive ataxic behaviour.Order
C3H/HeH Pde6b<rd1> 5Order
Gpi1<b> 7
Xic<a> X
C3;C-Chd7<Todo>/H Chd7<Todo> 4Headweaving and circling in heterozygotes. Homozygotes die at mid gestation with vascular and brain defects.Order From EMMA
Tyrp1<b> 4
Tyr<c> 7
Pde6b<rd1> 5
C3;C-Chd7<Edy>/H Chd7<Edy> 4Headweaving/circling.Order From EMMA
Tyr<c> 7
Tyrp1<b> 4
Pde6b<rd1> 5
C3;C-Chd7<Dz>/H Chd7<Dz> 4Dizzy. Heterozygote animals are small at birth with slight kink in tail and exhibit head weaving and circling behaviour. Order From EMMA
Tyr<c> 7
Pde6b<rd1> 5
Tyrp1<b> 4
B6.129P2(Cg)-Il1rn<t
m1Nick>/Nick 		Il1rn<tm1Nick> 2Strain resistant to arthritis, arteritis and psoriasis (seen in BALB/c) but highly susceptible to undefined 'malaise' under conventional conditions. Order From EMMA
B6.129P2(Cg)-Fgfr3<t
m1.1Aomw>/Aomw 		Fgfr3<tm1.1Aomw> 5All homozygous males, some homozygous females and some heterozygous males develop an abnormal skull phenotype sometimes with malocclusion, and may be smaller in size. The phenotype is not fully penetrant.Order From EMMA
C57BL/6-Lep<ob>/H Lep<ob> 6Order
B6CB-Tg(ATXN3*)84.2C
ce/H 		Tg(ATXN3*)84.2Cce Slowly progressive cerebellar defecit from 4weeks of age; wide flattened gait, clasping of all 4 limbs, neuronal loss, gliosis & neuronal intranuclear inclusions present in the pons & cerebellum, peripheral nerve demyelination.Order From EMMA
C57BL/6Apb-Ptprc<loc
>/Apb 		Ptprc<loc> 1Decreased expression of CD45 on CD19+ B cells etc.Order From EMMA
C57BL/6Apb-Zap70<mur
>/Apb 		Zap70<mur> 1Reduced naïve CD4+ and CD8+ T cells which are hyperactivated, reduced CD4+ cells, defect in TCR signal transduction, impaired but not severe response to anti-TCR stimulation, T cell intrinsic defect, elevated serum levels of IgG2b.Order From EMMA
B6;C3-A<vy>/H A<vy> 2Order
STOCK Krt25<Re>/H Krt25<Re> 11Order
B6;D2-Kitl<Sl-d>/H Kitl<Sl-d> 10Order
C57BL/6J-Ucp1<m1H>/H Ucp1<m1H> 8Homozygotes are unable to thermoregulate.Order
B6NTac;B6N-A<tm1Brd>
Slc25a4<tm1a(EUCOMM)Wtsi>/WtsiH 		Slc25a4<tm1a(EUCOMM)
Wtsi> 		8Potential EUMODIC data in the Mousephenotype.org database.Order From EMMA
C57BL/6N-Cib2<tm1a(E
UCOMM)Wtsi>/H 		Cib2<tm1a(EUCOMM)Wts
i> 		9Potential EUMODIC data in the Europhenome database.Order From EMMA
C57BL/6N-Mmp12<tm1a(
EUCOMM)Hmgu>/H 		Mmp12<tm1a(EUCOMM)Hm
gu> 		9Potential EUMODIC data in the Europhenome database.Order From EMMA
C57BL/6N-Tmem255b<tm
1a(EUCOMM)Hmgu>/H 		Tmem255b<tm1a(EUCOMM
)Hmgu> 		8Potential EUMODIC data in the Europhenome database.Order From EMMA
C57BL/6NTac-Atp8a1<t
m1a(EUCOMM)Wtsi>/H 		Atp8a1<tm1a(EUCOMM)W
tsi> 		5Potential EUMODIC data in the Europhenome database.Order From EMMA
C57BL/6NTac-Cd200<tm
1a(KOMP)Wtsi>/H 		Cd200<tm1a(KOMP)Wtsi
> 		16Potential EUMODIC data in the Europhenome database.Order From EMMA
STOCK a/a<t>/H a<t> 2(hair - colour) The back is black and the belly cream or yellow. GVSLM3: 1, 24.Order
B6Ola.Cg-Gpi1<a> Tyr
<c>/Gpi1<c> Tyr<c>/WsH 		Gpi1<b> 7Order From EMMA
Gpi1<c> 7
B6Ola.129S2-Gpi1<a>/
Gpi1<b>/WsH 		Gpi1<a> 7Order From EMMA
Gpi1<b> 7
B6Ola.AK-Gpi1<a> Tyr
<c>/Gpi1<b> +/WsH 		Gpi1<a> 7Order From EMMA
Gpi1<b> 7
B.Cg-Tg(Hbb-b1)83Clo
/WsH 		Tg(Hbb-b1)83Clo None expressed. Order From EMMA
C57BR/cd Tyrp1<b> 4Hepatomas in 25% of males.Order
a 2
C3H101H-Krt71<Ca-2H>
/H 		Krt71<Ca-2H> 15Allelism test with caracul: no recombinants out of 104 classified offspring. Matings to produce homozygotes not performed. Heterozygotes look like Ca/+.Order
Krt71<Ca-d>, Scn8a<m
ed> 		Scn8a<med> 15(Coat - texture, motor end plate).Order
Krt71<Ca-d> 15
129P2/OlaHsd-Tpcn1<G
t(XG716)Byg>/H 		Tpcn1 5Order
B6J;129S1-Capn5<tm1N
de>/H 		Capn5<tm1Nde> 7None apparent.Order From EMMA
Tg(UBC-Utrn)1Ked Dmd<mdx> XOrder
C3H;B6-Candy/H Hyperglycaemia, glycosuria. Elevated plasma glucose at 16 weeks of age. Glucose also detected in the urine at 24 weeks of age. Order From EMMA
C3H;B6-Candy2/H Elevated plasma glucose at 16 weeks of age. Glucose also detected in the urine at 24 weeks of age. Order From EMMA
C3H;B6-Candy3/H Elevated plasma glucose at 16 weeks of age. Glucose also detected in the urine at 24 weeks of age.Order From EMMA
C3H;B6-Candy4/H Elevated plasma glucose at 16 weeks of age. Glucose also detected in the urine at 24 weeks of age. Order From EMMA
C3H;B6-Candy5/H Elevated plasma glucose and phosphate at 16 weeks of age. Glucose also detected in the urine at 24 weeks of age.Order From EMMA
B6;129P2-Capn1<tm1Dg
en>/H 		Capn1<tm1Dgen> 19No overt phenotype.Order From EMMA
C57BL/6NTac-Capn5<tm
1a(EUCOMM)Hmgu>/H 		Capn5<tm1a(EUCOMM)Hm
gu> 		7Potential EUMODIC data in the Europhenome database. Order From EMMA
C3H.Cg-Casp3<I216F>/
H 		Casp3 8Reduced apoptosis in homozygotes. Phenocopies Caspase 3 null alleles.Order From EMMA
C3H-Cat2/H Cat2 1(eye - cataract) cataract-2 dominant cataract.Order
C3H;101H-Cryga<Tol>/
H 		Cryga<Tol> 1Dominant cataract.Order
C3H.Cg-Cat5<To2>/H Cat5<To2> 10(eye - cataract) cataract-5 dominant cataract.Order
CBA-TgN(IL5) 1 GlX Transgenic pups have high leucocyte counts and are readily identifiable by differential leucocyte counts.Order From EMMA
CBA/CaH Xic<a> XOrder
STOCK Runx1t1<tm1Fc>
/H 		Runx1t1<tm1Fc> 4Order
CCBAN3-2371 Order
CCBAN4-2513 Order
CCBAN4-2547 Order
129-Ccl6<tm1Roes>/H Ccl6 11None mentioned.Order From EMMA
C57BL/6NTac-Ccnyl1<t
m1a(EUCOMM)Wtsi>/H 		Ccnyl1<tm1a(EUCOMM)W
tsi> 		1Potential EUMODIC data in the Europhenome database.Order From EMMA
B6;129-Ccr9<tm1Dgen>
/H 		Ccr9<tm1Dgen> 9None.Order From EMMA
CD1.Cg-Fgfr2<tm4Lni> Fgfr2<tm4Lni> 7Heterozygote mice are viable and fertile with shortened face, protruding eyes, and show premature fusion of cranial sutures. Homozygous mutants display multiple joint fusions, cleft palate and trachea and lung defects, and die shortly after birth.Order From EMMA
B6CB-Tg(CD2-NPM/ALK)
4Sudt/H 		Tg(CD2-NPM/ALK)4Sudt Mice develop tumours of haemopoietic organs within 2 years of age in approx. 28% of mice. Transgene positive animals developed tumours in prominent abdominal lymph nodes, in the spleen, liver and/or thymus. Sometimes involvement of the peripancreatic/abdominal lymph nodes was detected. Liver tumours could also be seen by gross macroscopy.Order From EMMA
Tg(CD2-NPM/ALK)4Sudt UN
B6NTac;B6N-Cd28<tm1a
(EUCOMM)Hmgu>/H 		Cd28<tm1a(EUCOMM)Hmg
u> 		1Potential EUMODIC data in the Europhenome database.Order From EMMA
CD45R03 Under investigation: not severely immunocompromised.Order
CD45RABC3 Under investigation, not severely immunocompromised; no obvious immunological dysfunction.Order
CD45RB2 Under investigation: not severely immunocompromised.Order
CD45RO-C817S Severe defects in B and T cell differentiation and function.Order
CD45RO9 Under investigation, not severely immunocompromised.Order
CEMO_S2 Order
CEMO_S3 Order
CEMO_S5 Order
CHANGELING Motor co-ordination problems & death before weaning age.Order
Tg(UBC-Utrn)2Ked Dmd<mdx> XOrder
STOCK Tyr<c-ch>Mch/H Tyr<c-ch> 7Order
Mch
STOCK Oca2<p>Tyr<c-c
h>Myo7a<sh1>Prss8<fr>/H 		Oca2<p> 7Order
Prss8<fr> 7
Tyr<c-ch> 7
Myo7a<sh1> 7
C3H101H-Flt4<Chy>/H Flt4<Chy> 11Milky abdomen shortly after birth. (abdomen, feet) chylous ascites. From crosses of 3H1 females to heterozygous males, approx 40% of the offspring exhibited the milky abdomen phenotype, of these, about 50% survived through to weaning age.Order From EMMA
Chy-Ma like Chy13 (abdomen, feet) chylous ascites. Milky abdomen. Small at birth and weaning. May have low fertility. Some may have coat dilution or headbobbing. From crosses of heterozygous males to 3H1 females, fewer than 20% of the offspring exhibited the milky abdomen phenotype - viability of these to weaning age was good.Order
C3H101H-Chy2/H Chy2 (abdomen, feet , tail). Typical chylous phenotype of milky abdomen, puffy feet, swollen tail. No knowledge of fate of homozygote. From crosses of heterozygous males to 3H1 females, approx 25% of the offspring exhibit the milky abdomen phenotype, under half of these survive through to weaning.Order
C3H101H-Chy5/H Chy5 Milky abdomen. Breeding data suggest little or no pre or perinatal loss of heterozygotes,and that not all heterozygotes exhibit the milky abdomen phenotype. From crosses of 3H1 females to heterozygous males, under 30% of offspring exhibit the milky abdomen phenotype, of these, under 60% survive through to weaning.Order
Chy5 UN
C3H101H-Chy6/H Chy6 Milky abdomen after suckling at birth. Develop thickened tail and feet possibly due to oedema. Somes males become priapistic. Breeding data suggest some pre or perinatal loss of heterozygotes and reduced penetrance of milky abdomen phenotype. From crosses of 3H1 females to heterozygous males, under 30% of the offspring exhibit the milky abdomen phenotype, of these, under half survive through to weaning.Order
Chy6 UN
C3H101H-Chy7/H Chy7 (abdomen, feet) chylous ascites. Milky abdomen. Breeding data suggest that mutation is not fully penetrant. Proportion of live pups at birth with milky abdomen phenotype is 30%; survival rate of these affected offspring between birth and weaning is about 60%. Both heterozygous males and females have been shown to breed. Homozygotes have not been investigated.Order
Chy7 UN
CIRCA12 Identified in circadian rhythm screen. Has a reduced period lengthening response when subjected to constant light conditions.Order
CIRCA2 Long activity under constant dark period.Order
CIRCAD21 Order
C57BL/6NTac-Cisd2<tm
1a(EUCOMM)Wtsi>/H 		Cisd2<tm1a(EUCOMM)Wt
si> 		3Potential EUMODIC data in the Europhenome database.Order From EMMA
B6.Cg-Cited2<L247P>/
H 		Cited2 10Although the amino acid change occurs in a highly conserved residue, the mutant is homozygous viable and fertile, with no detectable phenotype. In trans to the Knock-out allele, it is viable and phenotypically normal. Order From EMMA
B6.129P2-Cited2<tm1B
ha>/BhaH 		Cited2<tm1Bha> 10Cardiac malformations, adrenal agenesis, fusion of cranial ganglia, abnormal cardiac neural crest migration, excencephaly and left-right patterning defects.Order From EMMA
129-Cited2<tm1Bha>/H Order From EMMA
B6.129-Cited2<tm2Bha
>/H 		Cited2<tm2Bha> 10Cre-mediated recombination throughout the entire epiblast of early embryos recapitulates the complete loss of function phenotype of Cited2, which include cardiac malformations, adrenal agenesis, fusion of cranial ganglia, abnormal cardiac neural crest migration, excencephaly and left right patterning defects.Order From EMMA
Tg(UBC-Utrn)3Ked Dmd<mdx> XOrder
CMV Gal4 None.Order From EMMA
STOCK Tg(Col2a1-cre)
1Bhr/H 		Tg(Col2a1-cre)1Bhr No overt phenotype.Order From EMMA
C3H101H-Col4a1<Bru>/
H 		Col4a1<Bru> 8(eyes - cataract - size, skin - colour) bruised.Order From EMMA
STOCK Col4a1<Raw>/H Col4a1<Raw> 8Retinal ateriolar wiring. Shiny retinal blood vessels.Order From EMMA
STOCK Col4a1<Svc>/H Col4a1<Svc> 8Small with vacuolar cataract. Also other eye abnormalities. Mutants are small and bruised at birth and tend to remain small throughout life. Variable eye findings, the most consistent of which is a vacuolar cataract. Other eye findings include enlarged eyes, corneal opacity, iris-corneal adhesions, iris-lens adhesions, retinal vascular abnormalities.Order From EMMA
CON Kitl<Sl-con> 10(coat - colour) steel. Darkly pigmented genitalia and slightly lighter coat in heterozygote. Homozygotes are grey with dark genitalia.Order
Edar<dl> 10
STOCK Gjb2<tm1Kwi>/H Gjb2<tm1Kwi> 14Heterozygotes appear wildtype and can hear, homozygous embryonic lethal.Order
C3H;C-Gjb2<E119stop>
/H 		Gjb2<E119stop> 14Homozygous embryonic lethalOrder From EMMA
Tg(UBC-Utrn)4Ked Dmd<mdx> XOrder
Cookson Mouse Eng 2Order
Cordon Bleu Cobl 11None.Order
STOCK Scrib<Crc>/H Scrib<Crc> 15Neural tube defects.Order
C3H.Cg-Scrib<Crc>/H Scrib<Crc> 15Order
C3H101HF1 x STOCK Ty
r<c> Crm/H 		Crm X(coat - colour) cream.Order
Tyr<c> 7
B6;129-Cry1<tm1Jhjh>
/H 		Cry1<tm1Jhjh> 10Order
B6.129S2-Ctse<tm1Bch
n>/H 		Ctse<tm1Bchn> 1Mice breed normally. No obvious phenotype has been described as yet but cathepsin E has been implicated in regulation of antigen processing, and other aspects of innate immunity.Order From EMMA
129-Ctsg<tm1.1Roes>/
H 		Ctsg<tm1.1Roes> 14Mice deficient in Ctsg are susceptible to fungal infections, despite normal neutrophil development and recruitment. Order From EMMA
B6Dnk;B6N-Cul7<tm1a(
EUCOMM)Wtsi>/H 		Cul7<tm1a(EUCOMM)Wts
i> 		17Potential EUMODIC data in the Europhenome database.Order From EMMA
STOCK Utrn<tm1Ked> D
md<mdx> Tg(Ckm-Dmd*)11956Chmb/H 		Dmd<mdx> XOrder From EMMA
Utrn<tm1Ked> 10
Tg(Ckm-Dmd*)11956Chm
b
Tg(Ckm-Dmd*)11956Chm
b 		UN
C3H;C-Gjb2<I128V>/H Gjb2<I128V> 14Heterozygotes appear wildtype and show normal hearing.Order From EMMA
B6;129P2-Cxcr1<tm1Dg
en>/H 		Cxcr1<tm1Dgen> 1No visible phenotype.Order From EMMA
C3;C-Chd7<Cycn>/H Chd7<Cycn> 4Headbobbing/circling. Heterozygotes exhibit headweaving and circling behaviour. Homozygous foetuses exhibit midgestational lethality potentially due to vascular and/or anterior neural tube defects.Order From EMMA
Tyr<c> 7
Pde6b<rd1> 5
Tyrp1<b> 4
STOCK Rbfox3<tm1a(EU
COMM)Hmgu>/H 		Rbfox3<tm1a(EUCOMM)H
mgu> 		11Potential EUMODIC data in the Europhenome database. Order From EMMA
D1ApA63(Knockin) Order
C3H;C-Dfp2/H Dfp2 4Heterozygotes have dark pigmentation on footpads and additional areas such as tail, ears etc.Order From EMMA
Pde6b<rd1> 5
Tyr<c> 7
Tyrp1<b> 4
DBA/2OlaHsd Myo5a<d> 9Non-agouti brown, pink eyes. Susceptible to audiogenic seizures. Spontaneous calcified heart lesions progress with age. Order
a 2
Tyrp1<b> 4
C3H101H-Dbf/H A<w> 2Many extra toes on all feet. Homozygote lethal. Dominant, digits - number, limbs - bones, size - small, reduced viability, skull, sterility, cerebrospinal fluid??Order From EMMA
Pde6b<rd1> 5
Dbf 1
C3H101HF1 x STOCK Dc
t<slt>/H 		Dct<slt> 14Slatey.Order
DDK Om 11Order
C3H101H-Del(1)55H/H Del(1)55H 1(size - birth - weaning) small at birth and weaning.Order
C3H101H-Del(1)57H/H Del(1)57H 1(size - birth, anaemia) Small at birth and seemingly anaemic.Order
C3H101H-Del(1)58H/H Del(1)58H 1(size - birth - weaning, hair - colour) small at birth and at weaning with dark coats.Order
C3H101H-Del(1)66H/H Del(1)66H 1(size - birth - weaning, hair - colour) heterozygote milky abdomen at birth, small at weaning. Some males sterile. Losses between birth and weaning.Order
C3H101H-Del(1)70H/H Del(1)70H 1(size - birth - weaning, head) small at birth and weaning sometimes with a domed head.Order
C3H101H-Del(1)6H/H Del(1)6H 1(size - birth - weaning, head) small at birth and weaning, with domed head.Order
C3H101H-Del(1)42H/H Del(1)42H 1(size - birth - weaning - eyes) small at birth with eyes open and small at weaning with small eyes.Order
C3H101H-Del(1)33H/H Del(1)33H 1(size - birth - weaning, head) small at birth and weaning, with a slightly domed head.Order
C3H101HF1 x STOCK De
l(1)27H/H 		Del(1)27H 1(size - birth weaning, hair - colour) small at birth and weaning, some have white feet. No information available about homozygotes.Order
C3H101H-Del(10)69H/H Del(10)69H 10(size - birth - weaning, head) heterozygotes small at birth and weaning, with domed head.Order
C3H101H-Del(10)41H/H Del(10)41H 10Steel.Order
C3H101H-Del(12)75H/H Del(12)75H 12(size - birth weaning, hair - colour, behaviour) Small at birth and small at weaning with head bobbing and dark coat.Order
C3H101H-Del(13)52H/H Del(13)52H 13(size - birth - weaning, hair - colour) small at birth and weaning, sometimes with dark coats.Order
C3H101HF1 x STOCK De
l(13)80H +/+ Foxq1<sa>/H 		Del(13)80H 13Del(13)80H carriers are small, with small eyes and domed heads. Del(13)80H +/+ sa has the satin phenotype.Order From EMMA
Foxq1<sa> 13
Del(13)80H 13
C3H101H-Del(13)36H/H Del(13)36H 13Order
Del(13)36H 13
C3H101HF1 x STOCK De
l(14)10H/H 		Dct<slt> 14Order
Del(14)10H 14
C3H101HF1 x STOCK De
l(14)15H/H 		Dct<slt> 14Order
Del(14)15H 14
C3H101HF1 x STOCK De
l(14)14H/H 		Dct<slt> 14Order
Del(14)14H 14
C3H101H-Del(14)23H/H Del(14)23H 14Order
C3H101HF1 x STOCK De
l(14)28H/H 		Del(14)28H 14Small at birth and weaning.Order
STOCK Del(14)31H/H Dct<slt> 14Order
Del(14)31H 14
C3H101HF1 x STOCK De
l(14)32H/H 		Dct<slt> 14Order
Del(14)32H 14
C3H101H-Del(14)29H/H Dct<slt> 14Order
Del(14)29H 14
C3H101HF1 x STOCK De
l(14)39H/H 		Dct<slt> 14(size) small with high expression.Order
Del(14)39H 14
C3H101H-Del(14)60H/H Del(14)60H 14Order
C3H101H-Del(16)51H/H Del(16)51H 16(size - birth - weaning, hair - colour) small at birth and weaning, some white feet.Order
STOCK Del(18)20H/H Del(18)20H 18(size - weaining, hair - colour, tail, cleft palate) small at weaning, sometimes white feet, variable tail abnormalities, tail kinks to tight curling of tail, some cleft palates/lips seen in heterozygotes also exencephaly.Order
C3H101H-Del(2)59H/H Del(2)59H 2(size - birth - weaning, genetalia - colour, head) Phenotype: small at birth and weaning with small eyes and domed/short heads. Some have dark genitalia.Order
C3H101H x STOCK Pax6
<Sey-2H>/H 		Pax6<Sey-2H> 2Small at birth and weaning. Small or closed eyes, white feet.Order
STOCK Pax6<Sey-4H>/H Pax6<Sey-4H> 2Small eyes and sometimes small at birth.Order
C3H101H-Del(2)35H/H Del(2)35H 2(size - birth - weaning, hair - colour) small at birth and weaning, sometimes white feet, occasional belly spot.Order
STOCK Del(3)48H/H Del(3)48H 3Carriers are small; males tend to be infertile.Order
C3H101H-Del(3)64H/H Del(3)64H 3(size - birth - weaning, head) small at birth and weaning, unusual shaped heads.Order
C3H101H-Del(4)17H/H Del(4)17H 4(size - birth - weaning, behaviour - waltzing, skin - colour) small at birth and weaning, waltzer type behaviour, variable white feet.Order
C3H101H-Del(5)68H/H Del(5)68H 5(size - birth weaning, behaviour) small at birth and weaning with erratic behaviour.Order
C3H101H-Del(5)43H/H Del(5)43H 5Order
C3H101H-Del(5)47H/H Del(5)47H 5Order
C3H101H-Del(5)25H/H Del(5)25H 5Patch.Order
C3H101H-Del(6)26H/H Del(6)26H 6(size - birth weaning, hair - colour) small at birth and weaning with dark (umbrous) coat.Order
C3H101H-Del(7)49H/H Del(7)49H 7(size - birth - weaning, hair - colour) small at birth and weaning, dark coats, white toes. Phenotype and deletion may not be associated.Order
C3H101H-Del(7)56H/H Del(7)56H 7(size - birth - weaning, hair - colour) small at weaning, some have milky abdomens.Order
C3H101H-Del(8)50H/H Del(8)50H 8(size - birth - weaning, hair - colour) small at birth and weaning, with dark coats. Homozygotes lost at pre-implantation stage.Order
C3H101H-Del(8)62H/H Del(8)62H 8(size, head, behaviour - circling) small, some with short heads, circling.Order
C3H101H-Del(8)72H/H Del(8)72H 8(size - birth weaning, hair - colour, behaviour) small at birth and weaning, also dark coats. Some show circling behaviour. Pre-implantation loss of homozygotes.Order
C3H101H-Del(8)7H/H Del(8A4-B3)7H 8(abdomen, feet) chylous ascites. From crosses of heterozygous males to 3H1 females, approximately 20% of the offspring exhibited the milky abdomen phenotype - under 60% of these survived through to weaning age.Order
Del(8)7H 8
C3H101H-Del(8)74H/H Del(8)74H 8(feet, tail) milky abdomen, puffy feet and thick tail. From crosses of heterozygous males to 3H1 females, approximately 20% of the offspring exhibited the milky abdomen phenotype, just under half of these survived through to weaning age. Data from openings suggest that homozygotes die by early implantation, and that prenatal loss of heterozygotes is low.Order
C3H101H-Del(9)4H/H Del(9)4H 9(size - small, white spotting) low grade white head/feet tail spotting, carriers small from birth.Order
129P2/OlaHsd-Tpcn2<G
t(YHD437)Byg>/H 		Tpcn2<Gt(YHD437)Byg> 7Order
C57BL/6J-H19<tm2Wrk>
/H 		H19<tm2Wrk> 7Deletion of the H19 transcription start site shows no effect on imprinting expression or DNA methylation. Order From EMMA
C3H101HF1 x STOCK Dh
/H 		Dh 1dominant hemimelia, Classified at birth by absence of spleen. Toes not always abnormal. Het.show preaxial polydactyly or oligodactyly of the hind limbs, tibial hemimelia, & sometimes reduction of the femur & pubic element of the pelvic girdle, no. etc...Order
C3;CAnN-Dilp3/H Dilp3 Dilated pupils.Order From EMMA
C3;C-Dilp4/H Dilp4 Mice carrying this mutation have permanently dilated pupils.Order From EMMA
C3H101H-Dkf/H Dkf (feet - colour, tail - colour, size - weaning) Darkfoot, dominant, homozygous lethal. Heterozygotes have dark foot-pads and tails, also slightly small at weaning.Order
Dkf UN
C3H101HF1 x STOCK Ed
ar<Dl-Slk2H>/H 		Edar<Dl-slk2H> 10Heterozygotes: greasy coat, hairy tail. Homozygotes: similar to heterozygotes, but have hairless tail.Order
C3H101H-Edar<Dl-slk>
/H 		Edar<Dl-slk> 10(hair, teeth) sleek.Order
STOCK Tmc1<dn>/WtsiH Tmc1<dn> 19Deafness.Order From EMMA
B6NTac;B6N-Dnajc19tm
1a(EUCOMM)Hmgu/H 		Dnajc19<tm1a(EUCOMM)
Hmgu> 		3Potential EUMODIC data in the Europhenome database.Order From EMMA
B6NTac;B6N-Dnase2b<t
m1a(EUCOMM)Hmgu>/H 		Dnase2b<tm1a(EUCOMM)
Hmgu> 		3Potential EUMODIC data in the Europhenome database.Order From EMMA
C3H101H-Dp(1)6H/H Dp(1)6H 1Small at birth and weaning.Order
STOCK Mut1069/H Mut1069 Affected Mut1069/+ pups are small at birth and weaning with domed head and sometimes dark coats. Affected pups are circa 55% of the weight of their gender matched wild-type sibs at weaning. From outcrosses of both heterozygous females and heterozygous males to wild-type, approximately 20% of pups at weaning exhibit the mutant phenotype indicating their reduced viability and/or reduced penetrance of the mutation. Average litter size from heterozygous females to (C3H/HeHx101/H)F1 males was 3.89 (393 pups from 101 litters) and 7.27 (560 pups from 77 litters) from the reciprocal, indicating reduced fertility and/or ability to carry pups to term of Mut1069/+ females. Homozygotes have not been investigated. Cytogenetics: possible proximal chromosome 1 duplication, but this has not been confirmed.Order
C3H101H-Dp(12)7H/H Dp(12)7H 12joined toes on hind feet.Order
C3H101H-Dp(12)9H Dp(12)9H 12dark coat and skin seen on ears, feet and tail with occasional domed head.Order
C3H101H-Dp(13)17H/H Dp(13)17H 13Small at birth and weaning.Order
C3H101H-Dp(14)18H Dp(14)18H 14small at birth and weaning, some have dark coats.Order
C3H101HF1 x STOCK Dp
(14)2H/H 		Dp(14)2H 14Phenotype variable and includes dark coat, small, white toes/feet.Order
C3H101H-Dp(15)5H/H Dp(15)5H 15Slightly small at weaning, some show erratic waltzing type behaviour, variable white feet/tail, dark coats.Order
C3H101H-Dp(16)15H/H Dp(16)15H 16Small at birth and weaning, sticky eyes, domed head.Order
C3H101H-Dp(16)8H Dp(16)8H 16Order
C3H101H-Dp(18)4H/H Dp(18)4H 18Small with dark coats.Order
C3H101H-Dp(2)11H Dp(2)11H 2(size - birth - weaning, hair - colour, behaviour) small at birth and small at weaning with dark coat and showing abnormal behavior. i.e. shaking, head bobbing and very active.Order
C3H101H-Dp(3)10H Dp(3)10H 3(size, head) heterozygotes are usually small with a domed head.Order
C3H101H-Dp(4)20H Dp(In4)20H 4Heterozygotes are small at birth and weaning, and exhibit a short domed head, some have a dark coat and low grade white spotting on the feet. Limited weight data indicate that Dp(4)20H/+ are circa 20% lighter at birth and about 40% lighter by weaning than their wild-type sibs. Viability of heterozygotes at birth and through to weaning is good, but breeding data suggest that this is reduced in larger litters. Opening data indicate that homozygotes are probably lethal and lost pre-implantation. Cytogenetics: additional material was seen in proximal Chr4 by G-banding. It was considered that the aberration is most likely to be an inverted duplication of bands 4A3-B1 (see Cattanach et al Mouse Genome 94 (3) p680).Order
Dp(In4)20H 4
C3H101H-Dp(7)1H/H Dp(7)1H 7Small at weaning, dark coats (some).Order
C3H101H-Dp(7)16H Dp(7)16H 7small at birth and small at weaning with dark coats.Order
C3H101H-Dp(7)19H Dp(7)19H 7Small at birth and weaning.Order
C3H101H-Dp(9)12H/H Dp(9)12H 9Small with dark coat.Order
C3H101H-Dp(9)14H/H Dp(9)14H 9Small at birth and weaning, some have dark coats, short heads and twisted jaws.Order
C3H101H-Dp(9)3H Dp(9)3H 9Heterozygotes small at birth and weaning, some fused toes, pointed faces.Order
C57BL/6NTac-Dpm2<tm1
a(EUCOMM)Hmgu>/H 		Dpm2<tm1a(EUCOMM)Hmg
u> 		2Potential EUMODIC data in the Europhenome database.Order From EMMA
STOCK Lmx1a<dr-J> Lmx1a<dr-J> 1Deafness, circling behaviour and hyperactivity in homozygotes. They have neuronal migration disorders in the cerebral cortex, cerebellum and hippocampus. White belly spots, short tails and abnormalities of the fallopian tubes (dr<2J> only)are seen in some.Order
B6.CAnNCrl(C3)-Dync1
i2<m1H>/EmcfH 		Currently being tested, trend towards slight locomotor deficit, nothing significant so far.Order From EMMA
B6.Cg-Dync1li1<m1Emc
f>/H 		Mouse not completely assessed but so far homozygotes have behavioural and neurological changes.Order From EMMA
C3H101HF1 x STOCK Mc
1r<E-tob>/Mc1r<e>/H 		Mc1r<E-tob> 8Order
Mc1r<e> 8
ecd Cartilage type defect.Order
STOCK Ednrb<s-136H>/
H 		Ednrb<s-136H> 14Less spotting than Ednrb<s>: white on belly and usually on back; small head spot.Order
C3H101H-Ednrb<s-162H
>/H 		Ednrb<s-162H> 14Intercross tests inconclusive, but suggest that homozygotes are smaller than wild-type littermates.Order
B6.129P2-Efnb1<tm1Rh
a>/Rha 		Efnb1<tm1Rha> XKnockout mice exhibit omphalocele, mispaired sternabrae, palate abnormalities, skull abnormalities, females additionally exhibit polysyndactyly.Order From EMMA
CBA.129P2-Efnb1<tm1R
ha>/Rha 		Efnb1<tm1Rha> XAxial skeletal abnormalities and skull malformation, abnormal body wall closure and cleft palate.Order From EMMA
Eh Eh 15Hairy ears (Eh). Reduced pinna with tufts of hair on inner surface. Homozygous lethal. Breeding poor when crossed to C57BL/6J. Order
B6.129P2-Ehmt2<Gt(ES
62)Feil> 		Ehmt2<Gt(ES62)Feil> 17Homozygotes are embryonic lethal at ~8.5 dpc. Show retardation of growth, abnormal imprinting and open neural tube.Order From EMMA
B6NDen;B6N-Eif2b1<tm
1a(EUCOMM)Hmgu>/H 		Eif2b1<tm1a(EUCOMM)H
mgu> 		5Potential EUMODIC data in the Europhenome database.Order From EMMA
B6Dnk;B6N-Elk4<tm1a(
EUCOMM)Wtsi>/H 		Elk4<tm1a(EUCOMM)Wts
i> 		1Potential EUMODIC data in the Europhenome database.Order From EMMA
ELK6K<-/->(lambda)<-
/-> 		Production of rat kappa light chains on mouse lambda and kappa light chain knockout background.(or on mouse kappa-type light chain knockout only, with mouse lambda-type light chain being wild type instead of knockout.Order
C57BL/6NTac-Elmod1<t
m1a(EUCOMM)Hmgu>/H 		Elmod1<tm1a(EUCOMM)H
mgu> 		9Potential EUMODIC data in the Europhenome database.Order From EMMA
B6;129P2-Eltd1<tm1Dg
en>/H 		Eltd1<tm1Dgen> 3None.Order From EMMA
B6.129-Mrc2<tm1Cmi>/
CmiH 		Mrc2<tm1Cmi> 11Homozygous Endo180DeltaEx2-6/Endo180DeltaEx2-6 mice are phenotypically normal (at the gross level), healthy and fertile.Order From EMMA
129-Epc1<tm1e(EUCOMM
)Wtsi>/WtsiH 		Epc1 18Order From EMMA
B6Dnk;B6N-Ercc2<tm1a
(EUCOMM)Wtsi>/H 		Ercc2<tm1a(EUCOMM)Wt
si> 		7Potential EUMODIC data in the Europhenome database.Order From EMMA
C3H101H x STOCK Es3<
c-nH>/Es<b>/H 		Es3<c-nH> 11Complete loss of enzyme activity as judged by staining pattern of red blood cell extracts following electrophoresis on Titan III plates. Heterozygotes are viable and fertile. Homozygotes not fully investigated, but probably prenatal lethal.Order
B6;129P2-Esr2<tm1Dge
n>/H 		Esr2<tm1Dgen> 12No visible phenotype.Order From EMMA
129S9/SvEvH-Evta/H Evta White coat with non-agouti specking and occasional non-agouti patches.Order From EMMA
B6NDen;B6N-Slc38a10<
tm2a(EUCOMM)Wtsi>/H 		Slc38a10<tm2a(EUCOMM
)Wtsi> 		11Potential EUMODIC data in the Europhenome database.Order From EMMA
B6;CBA-Dmd<mdx>Tg(AC
TA1-Utrn)1Ked/Ked 		Dmd<mdx> XOrder
C3;CAnNCrl-Fers/H Fers 4Heterozygotes have abnormal hind limbs, vigourous touch escape and circling. Order From EMMA
Tyr<c> 7
Pde6b<rd1> 5
Tyrp1<b> 4
Tg(ACTA1-Utrn)2Ked Dmd<mdx> XOrder
FMLC-TM/12 Statistically elevated levels of leptin & adiponectin after overnight fasted bleeds at 12 weeks of age with increased bodyweight. Bodyweight & adiponectin levels still elevated after an overnight fasted bleed at 16wks of age. After DEXA analysis: statistically increased bodyweight, fat mass & % body fat.Order
C3H101H-Fnld/H Fnld XFaint lined.Order
C3H;C-Gsdma3<Fgn>/H Gsdma3<Fgn> 11Mice carrying this mutation show progressive hair loss. Weanlings show a typical ragged coat phenotype. Following this mice go through several cycles of hair loss and regrowth. Adult mice eventually become almost hairless with a small amount of hair around the snout. Order From EMMA
FNOS2 Circling, vestibular defects. Heterozygotes can be identified by mild head bobbing or circling behaviour. Mice with this behaviour usually show morphological changes in the inner ear. Order From EMMA
129(CD1)-Foxh1<tm1Jl
w>/H 		Foxh1<tm1Jlw> 15Homozygous lethal at day 8 of gestation.Order From EMMA
C3H.Cg-Foxq1<sa>/H Foxq1<sa> 13I=glossy coat when homozygous CON=glossy coat.Order
FRAG 1 The minichromosome (Frag1) is about one fifth of the size of Chr19. G-banding showed the presence of centric heterochromatin, but no obvious euchromatin distal to the centric region. In situ probe results suggest that Frag1 is linear with telomeric sequences at both ends bordering minor and major satellite DNA sequences within. The possibility of a small component of euchromosomal material cannot be discounted. Chromosome specific paints have not been used, so the origin of the minichromosome has not been ascertained. Outcrosses of both female and male mice carrying one copy of Frag1 produced just over 40% of offspring with one copy of the minichomosome. Intercrosses produced offspring with 0, 1 and 2 copies of Frag1 that did not differ significantly from the expected ratios. Males, but not females, carrying two copies of Frag1 were shown to be infertile and this is associated with both reduced sperm count and increased proportion of abnormal sperm. No other overt phenotype has been noted.Order
Frag X Order
Fragal (CEMO_A1) Order
Tg(ACTA1-Utrn)3Ked Dmd<mdx> XOrder From EMMA
B6;129-Fshr<tm1Mha>/
H 		Fshr<tm1Mha> 17Homozygous males are fertile, but testis weight is reduced (~50% of normal). Homozygous females are infertile, ovulation does not occur. Heterozygous males are indistinguishable from wild type.Order From EMMA
FT Vps33a<bf> 5Order
Fgf5<go> 5
Tht 5
C3H101HF1 x STOCK Ax
in1<Fu-kb> Itpr3<tf>f/H 		Axin1<Fu-kb> 17Knobbly. Heterozygotes have short, bent tails.Order
C3H;C-Gena346/H Small, abnormal limbs (short and stick like). May exhibit high glucose. Order
FVB/N-Tg(ACTB-cre)2M
rt/J 		Tg(ACTB-cre)2Mrt This Cre recombinase strain is under the human beta actin gene promoter. This strain expresses Cre recombinase in all cells of the embryo by the blastocyst stage of development.Order
G6pd<b> G6pdx<a-m1Neu> XLow activity of glucose 6 phosphate dehydrogenase.Order
STOCK G6pdx<a-m1Neu> G6pdx<a-m1Neu> XLow glucose-6-phosphate dehydrogenase-a activity variant. Described in 'Genetic variants and strains of the laboratory mouse' page 273 and by Charles & Pretsch (1984) Mouse News Letters, 71; 37-38 as having three levels of G6PD activity: 20% in hemizygous males, 60% in heterozygous females and 15% in homozygous females compared to wild-type. Similar levels (12%, 56% and 9% of wild-type respectively) were seen by Peters et al Genet Res 52:195-201. Peters et al reported a reduced recombination frequency between Hq-G6pd-Ta suggesting the X chromosome carrying G6pdx<a-m1Neu> suppresses recombination in this region, but no evidence of a structural rearrangement was detected cytologically. Peters & Ball (Genet Res 56: 245-252) showed greater expression of G6PD in the blood of G6pdx<a-m1Neu>/G6pdx<a> than in the reciprocal (maternal allele quoted first). This difference was greater in older mice (2-6 months) than in younger mice (one month). Sanders et al (Mut Res 374:79-87) reported finding an A to T transversion in G6pdx<a-m1Neu> at the 5' splice site consensus sequence at the 3' end of exon 1, part of the untranslated region, which is a likely cause of the lowered activity.Order From EMMA
B6;129P2-Galr2<tm1Dg
en>/H 		Galr2<tm1Dgen> 11No visible phenotype.Order From EMMA
Gammy (JU) Club foot in one or both hind limbs.Order
Tg(ACTA1-Utrn*)1Ked Dmd<mdx> XOrder
C3H.C-Gars<C201R>/H Gars<C201R> 6Mice heterozygous for this dominant mutation exhibit low limb tone, low grip strength and poor wire manoeuvrability. Heterozygous mice with a C3H genetic background have loss of grip strength, decreased motor flexibility and disruption of fine motor control. Homozygous mutants have a highly deleterious set of features, including movement difficulties and death before weaning.Order From EMMA
Tg(ACTA1-Utrn*)2Ked Dmd<mdx> XOrder
129-Elane<tm1(cre)Ro
es>/H 		Elane<tm1(cre)Roes> 10Impaired innate immunity.Order From EMMA
129-Elane<tm1(cre)Ro
es>Ctsg<tm1.1Roes>/H 		Elane<tm1(cre)Roes> 10Impaired innate immunity.Order From EMMA
Ctsg<tm1.1Roes> 14
C3H;C-Gena381/H Pde6b<rd1> 5High Alkaline phosphatase, low cholesterols, distinguishable by blood testing. Some mutants are smaller and have a darker coat colour.Order From EMMA
Tyr<c> 7
Tyrp1<b> 4
C3H;C-Gena394/H Pde6b<rd1> 5Impaired Glucose Tolerance (IGT).Order From EMMA
Tyr<c> 7
Tyrp1<b> 4
C3H;C-Gena111/H Pde6b<rd1> 5Small at birth and weaning. Waddler behaviour. Rough coat.Order From EMMA
Tyr<c> 7
Tyrp1<b> 4
C3;C-Emx2<Pdo>/H Emx2<Pdo> 19Mice heterozygous for this mutation carry a dominant mutation that causes syndromic hearing loss and is possibly a novel mouse model of Leopard Syndrome. Currently known defects in affected mice include conductive hearing loss due to malformation of the ossicular chain and sensineural deafness due to an extra inner and outer row of stereocillia hair cellls in the cochlea. Heart defects are also suspected but have not been confirmed.Order From EMMA
Tyrp1<b> 4
Tyr<c> 7
Pde6b<rd1> 5
C3H;C-Gena187/H Pde6b<rd1> 5High locomotive activity and arousal activity in heterozygotes.Order From EMMA
Tyr<c> 7
Tyrp1<b> 4
C3H;C-Gena221/H Pde6b<rd1> 5Heterozygotes are smaller than wildtypes. Order From EMMA
Tyr<c> 7
Tyrp1<b> 4
C3H;C-Tuba1a<Jna>/H Pde6b<rd1> 5Behavioural. High locomotor activity (LMA). Heterozygotes are detected by measuring beam-splitting activity in LMA cages. Homozygosity has not been tested. GENA227 exhibits spontaneous hyperactivity in the absence of deafness and circling. Order From EMMA
Tyr<c> 7
Tyrp1<b> 4
Tuba1a<Jna> 15
C3H;C-Lch/H Pde6b<rd1> 5Low levels of Total and HDL CholesterolOrder From EMMA
Tyr<c> 7
Tyrp1<b> 4
C3H;C-Gena316/H Pde6b<rd1> 5GENA316/+ animals have poor rota rod performance.Order From EMMA
Tyr<c> 7
Tyrp1<b> 4
C3H;C-Gena323/H Pde6b<rd1> 5Large body size (+125%) and flaccid abdonimal tone.Order From EMMA
Tyr<c> 7
Tyrp1<b> 4
C3H.Cg-Gena339/H Tyr<c> 7Mice heterozygous for this mutation have cranofacial abnormalities observed as a broad head.Order From EMMA
Pde6b<rd1> 5
Tyrp1<b> 4
C3H;C-Gena344/H Pde6b<rd1> 5High pelvic elevation.Order From EMMA
Tyr<c> 7
Tyrp1<b> 4
C3H;C-Gena353/H Pde6b<rd1> 5GENA353/+ animals have no response to touch escape. Order From EMMA
Tyr<c> 7
Tyrp1<b> 4
C3H;C-Gena357/H Pde6b<rd1> 5Intermittent fits and marked resting tremor.Order From EMMA
Tyr<c> 7
Tyrp1<b> 4
C3H;C-Gena360/H Pde6b<rd1> 5Low total choloesterol and HDL cholesterol.Order From EMMA
Tyr<c> 7
Tyrp1<b> 4
C3H;C-Pmp22<Tr-3H>/H Pde6b<rd1> 5Fits and marked resting tremors. Mice heterozygous for this mutation exhibit hypomyelination abnormalities and have a marked resting tremor.Order From EMMA
Tyr<c> 7
Tyrp1<b> 4
Pmp22<Tr-3H> 11
C3H;C-GENA371/H Tyr<c> 7No tail.Order
Pde6b<rd1> 5
Tyrp1<b> 4
C3H;C-Gena377/H Pde6b<rd1> 5Heterozygote animals fall off the rota rod. Order From EMMA
Tyr<c> 7
Tyrp1<b> 4
C3H;C-Gena396/H Tyr<c> 7Mice heterozygous for this mutation have high blood glucose concentrations (hyperglycaemia).Order From EMMA
Tyrp1<b> 4
Pde6b<rd1> 5
C3H;C-Gena397/H Pde6b<rd1> 5Hypoglycaemic.Order From EMMA
Tyr<c> 7
Tyrp1<b> 4
C3H.CAnN-Scn8a<Clth>
/H 		Tyr<c> 7Cloth-ears mice show reduced acoustic startle response and mild hearing loss from about 30 days old. Tests indicate that the peripheral neural auditory pathway is impaired in these mutants, but that cochlear function is normal. Both homozygotes and heterozygotes display paroxysmal tremor episodes with behavioural arrest. Homozygotes demonstrate a milder continuous tremor during movement and rest. Order From EMMA
Pde6b<rd1> 5
Tyrp1<b> 4
Scn8a<Clth> 15
C3H;C-Gena401/H Tyr<c> 7Mice carrying this mutation display late onset deafness after 6 months of age. Suspected homozygotes also show circling/deaf/headbobbing/hyperactive behaviour.Order From EMMA
Tyrp1<b> 4
Pde6b<rd1> 5
C3H.Cg-Gena100/H Mice carrying this mutation have dark pigmentation on their footpads and additional areas such as the ears and tail. Some litter mates may also be small. Order From EMMA
C3H.Cg-Gena115/H Small at birth and weaning. Small testis. Outcross of the original mutant female generated pups that could be placed in two groups: 28 with normal weight at birth, 24 with reduced weight. The reduced weight group were more than 20% lighter than there normal sibs at birth and similarly reduced at weaning.Order From EMMA
C3H;C-GENA119/H Original mutant displayed circling, limb grasping and trunk curling behaviour. In subsequent stock matings, no circling behaviour was noted, however abnormal limb grasping and trunk curling were seen as well as squint jaw/bent face, tail curl/kink. Outcrosses of heterozygous males to C3H generated 42 abnormal offspring, 61 wild-type and 53 not or unable to be scored. The average litter size of 6.5 suggests little or no pre-natal loss. One heterozygous female also shown to be fertile.Order
B6.Cg-Ctnnb1<Bfc>/H Ctnnb1<Bfc> 9Short domed head.Order
C3.Cg-Ctnnb1<Bfc>/H Ctnnb1<Bfc> 9Short broad head, dark pigmentation, abnormal gait and plevic elevation. Mice heterozygous for this mutation have abnormal facial pigmentation, cranofacial abnormalities observed as broad head and skeletal abnormalities observed as an abnormal gait and elevated pelvis. Order From EMMA
Tyr<c> 7
Pde6b<rd1> 5
Tyrp1<b> 4
C.Cg-Ctnnb1<Bfc>/H Ctnnb1<Bfc> 9Short broad head, dark pigmentation, abnormal gait and plevic elevation. Mice heterozygous for this mutation have abnormal facial pigmentation, cranofacial abnormalities observed as broad head and skeletal abnormalities observed as an abnormal gait and elevated pelvis. Order
B6C3-Ctnnb1<Bfc>/H Ctnnb1<Bfc> 9Short domed head.Order
C3H;C-Gena127/H Heterozygotes have a pigmentation defect where the coat is lighter than agouti. Outcrosses of heterozygotes to C3H/HeH produced 85 light coated offspring out of 194 pups scored indicating that the penetrance of Gena127 and viability of heterozygotes is good. Intercrosses of heterozygotes failed to produce any pups with a more extreme phenotype than that of the heterozygote; with average litter size of 6.25 from intercrosses compared to 8.44 from outcrosses these data suggest that homozygotes are lethal prenatally. Note on Stocklist states that light coat is not due to a mutation at the steel locus, but no breeding data were found to confirm this statement.Order From EMMA
C3H.Cg-Gena135/H Mice carrying this mutation have an abnormal gait (hunched, jerky, darting), tail rattle, evidence of aggression in arena, vigourous touch escape response and tachycardia.Order From EMMA
C3H;C-GENA140/H Small with short head.Order
C3H.Cg-Gena143/H Abnormal gait and waddling movement.Order From EMMA
C3H;C-GENA144/H Passive.Order
C3H;C-GENA15/H Small, extra digit.Order
C3H;C-GENA151/H High activity.Order
C3H.Cg-Gena155/H Heterozygotes are small with elevated pelvic limbs.Order From EMMA
C3H;C-Gena160/H Head shaking , belly spot, white toes.Order From EMMA
C3H.Cg-Gena172/H GENA172/+ animals have white feet and a belly spot.Order From EMMA
c3H;C-GENA185/H Dominant behavoiural mutant with high gait, balance problems and strong grip.Order
C3;CAnN-Icst/H Icst 2Abnormal gait and iris corneal strands.Order From EMMA
C3H.Cg-Gena200/H Heterozygotes have a reduced or absent toe pinch response and/or reduced grip strength in SHIRPA assessment.Order From EMMA
GENA203/mod GENA203 mod/+ have an extra digit on one hind limb. GENA203 mod/Spgl have extra digits on all four limbs. Both have bone abnormalities.Order
GENA214 Very active, circling, limb grasp, no toe pinch.Order
C3H;C-GENA217/H Low PPI.Order
C3H;C-Gena228/H Headweaving and circling in heterozygotes.Order From EMMA
C3H;C-Gena243/H Pde6b<rd1> 5Low Total and HDL cholesterol.Order From EMMA
Tyr<c> 7
Tyrp1<b> 4
C3H;C-Gena26/H Low muscle tone, belly spot, white feet, short crinkly tail.Order From EMMA
C3H;C-GENA287/H Pde6b<rd1> 5Heterozygotes are small at birth and maturity with striped coat. Order
Tyr<c> 7
Tyrp1<b> 4
C3H.C-Zic2<Ku>/H Zic2<Ku> 14The Kumba mouse (also known as GENA29) has three possible phenotypes, belly spot, curly tail, or spina bifida. Arose because of looped tail and or ventral spotting. Rare (~2%) instances of spina bifida were also observed. Mutation maintained by backcrosses to C3H. The C3H background seems to decrease the penetrance of the visible heterozygous phenotypes. The homozygous mutation causes mid gestation lethality, with embryos exhibiting neural tube and other defects.Order From EMMA
129S9.Cg-Zic2<Ku>/H Zic2<Ku> 14The Kumba mouse has three possible phenotypes, belly spot, curly tail, or spina bifida. Arose because of looped tail and or ventral spotting. Rare (~2%) instances of spina bifida were also observed. The homozygous mutation causes mid gestation lethality, with embryos exhibiting neural tube and other defects.Order
C3H.Cg-Gena31/H Heterozygote females have a stripey coat at 8 days indicative of X-inactivation. Hemizygous males do not survive. Phenotype of heterozygous females has not been characterised in detail.Order From EMMA
C3H.Cg-Gena313/H Heterozygote animals have a poor righting reflex and also have a small body size. Order From EMMA
C3H;C-Gena318/H Pde6b<rd1> 5Irritable at SHIRPA test, kinky tail, high locomotive activity.Order From EMMA
Tyr<c> 7
Tyrp1<b> 4
C3H.Cg-Gena321/H Tyr<c> 7High Startle. Heterozygotes are detected by measuring response to 110 db tones. They are hyper responsive to sudden pulses of sound. The underlying cause may be neurological or behavioural. Homozygosity has not been tested to date.Order From EMMA
Pde6b<rd1> 5
Tyrp1<b> 4
C3H;C-GENA327/H High triglycerides.Order
C3H;C-Alpl<Hpp>/H Tyr<c> 7Mice with this mutation have low plasma alkaline phosphatase.Order From EMMA
Pde6b<rd1> 5
Tyrp1<b> 4
Alpl<Hpp> 4
C3H;C-GENA342/H Headweaving/headbobbing and circling in heterozygotes.Order
C3;C-Gck<Gena348>/H Tyrp1<b> 4Mice heterozygous for this mutation have high blood glucose and increased body weight. Order From EMMA
Tyr<c> 7
Gck<Gena348> 11
Pde6b<rd1> 5
C3H.Cg-Gena350/H Abnormal gait, vigorous touch escape.Order From EMMA
C3H.Cg-Gena359/H GENA359/+ animals have a lower left eye, blunt nose, craniofacial defect.Order From EMMA
C3;C-Flna<Dilp2>/H Flna<Dilp2> XDilated pupils in heterozygotes.Order From EMMA
Tyr<c> 7
Tyrp1<b> 4
Pde6b<rd1> 5
C3H;C-GENA382/H Animals from this stock have abnormally high levels of alanine transferase (ALT) and asparate tansferase (AST).Order
C3H;C-Gena383/H Abnormally high levels of plasma sodium and chloride.Order From EMMA
C3H;C-Gena391/H Pde6b<rd1> 5Lipid and glucose perturbations.Order From EMMA
Tyr<c> 7
Tyrp1<b> 4
C3H;C-Gena40/H Dark coat.Order From EMMA
C3;C-Rasgrf1<enu1H>/
H 		Rasgrf1<enu1H> 9Small mice when inherited through an affected male-imprinting mutation.Order From EMMA
C3H;C-Gena91/H Tremor.Order From EMMA
C3H.Cg-Sho2/H Sho2 GENA93 animals have cranofacial abnormalities observed as shorthead. Order From EMMA
Tg(ACTA1-Utrn*)3Ked Dmd<mdx> XOrder
Tg(ACTA1-Utrn*)4Ked Dmd<mdx> XOrder
C57BL/6NTac-Ggt1<tm1
a(EUCOMM)Wtsi>/H 		Ggt1<tm1a(EUCOMM)Wts
i> 		10Potential EUMODIC data in the Europhenome database.Order From EMMA
C3H/HeH-Gja8<No2>/H Gja8<No2> 3Cataract in lens nucleus, more severe in homozygotes. Order From EMMA
C3H101H-Gli3<Xt>/H Gli3<Xt> 13Extra toes.Order
C3H101H-Gli3<Xt-2H>/
H 		Gli3<Xt-2H> 13Extra toes.Order
C57BL/6NTac-Gm5134<t
m1a(EUCOMM)Hmgu>/H 		Gm5134<tm1a(EUCOMM)H
mgu> 		10Potential EUMODIC data in the Europhenome database.Order From EMMA
129S2.Cg-Gnas<tm2Kel
>/H 		Gnas<tm2Kel> 2There is a behavioural phenotype: response to novel environments as measured through activity in various tasks. This targeted allele has been shown to represent a null for Nesp55 protein.Order From EMMA
B6.Cg-Gnas<tm2Kel>/H Gnas<tm2Kel> 2There is a behavioural phenotype, response to novel environments as measured through activity in various tasks.Order From EMMA
Tg(ACTA1-Utrn*)5Ked Dmd<mdx> XOrder
C3H101H x STOCK Gpi1
<c>/H 		Gpi1<a> 7Order
Gpi1<b> 7
Gpi1<c> 7
C3H101H-Gpi1<a-m1H>/
H 		Gpi1<a-m1H> 7Order
Gpi1<a> 7
Gpi1<b> 7
Gpi1-s<TEM> Gpi1<b> 7Order
Gpi1<a> 7
B6;129P2-Gpr56<tm1Dg
en>/H 		Gpr56<tm1Dgen> 8NoneOrder From EMMA
129S2;129P2-Gca<tm1R
oes>/H 		Gca<tm1Roes> 2Minimal.Order From EMMA
Tg(ACTA1-Utrn*)6Ked Dmd<mdx> XOrder
B6Dnk;B6N-Snip1<tm1a
(EUCOMM)Wtsi>/H 		Snip1<tm1a(EUCOMM)Wt
si> 		4Potential EUMODIC data in the Europhenome database.Order From EMMA
B6;129P2-Grm1<tm1Dge
n>/H 		Grm1<tm1Dgen> 10No visible phenotype.Order From EMMA
B6;129P2-Grm4<tm1Dge
n>/H 		Grm4<tm1Dgen> 17No visible phenotype.Order From EMMA
B6;129P2-Grm5<tm1Dge
n>/H 		Grm5<tm1Dgen> 7No visible phenotype.Order From EMMA
B6;129P2-Grm8<tm1Dge
n>/H 		Grm8<tm1Dgen> 6No visible phenotype.Order From EMMA
C3H101H-Gs/H Gs XGreasy.Order
129S6/SvEvTac-Gt(ROS
A)26Sor<tm1Coll>/H 		No obvious phenotype. Order From EMMA
Guthrie [SP] Huntington's disease, enhancer of tremor onset.Order
Hba<c2> Hba<c2> 11Electrophoretic variant: amino acid substitution in haemoglobin alpha chain, amino acid 127* Lysine to Asparagine (equivalent to Haemoglobin Jackson in man). * Now considered to be aa128. Homozygotes viable and fertile.Order
Hba<cm> Hba-a2<c-m1H> 11Homozygotes viable and fertile.Order
C3H101H-Hbb<d3>/H Hbb<d> 7Homozygotes lethal: pups probably die due to anaemia.Order
Hbb<s> 7
C3H101H-Hbb<d4>/H Hbb<d4> 7Electrophoretic variant due to amino acid substitution in haemoblobin beta chain: beta 145 tyrosine to cysteine. Mutants have polycythaemia. This is an exact model of haemoglobin Rainier in man (see PMID:3839762). Homozygous females fail to breed, homozygous males are fertile.Order
Hbb<d> 7
C3H101HF1 x STOCK Hb
b<d5>/H 		Hbb<d> 7Mutation causes loss of protein product.See PMID:3749096. Homozygotes viable and fertile.Order
Hbb<d5> 7
Hbb<d6> Hbb<s> 7Mutation causes a reduction in haemoglobin beta protein. See PMID:3749096. Homozygotes viable and fertile.Order
Hbb<d6> 7
C3H101H-Hbb<d7>/Hbb<
d>/H 		Hbb<d> 7Mutation causes loss of haemoglobin beta variant d minor band. See PMID:3749096. Homozygotes viable and fertile.Order
Hbb<d7> 7
B6N;B6J-Tyr<c-Brd> H
erc3<tm1a(EUCOMM)Wtsi>/WtsiH 		Herc3<tm1a(EUCOMM)Wt
si> 		6Potential EUMODIC data in the Europhenome database.Order From EMMA
STOCK Nox3<het>/JH Nox3<het> 17Heterozygotes can have abnormal circling behaviour & hyperactivity. Homozygotes also exhibit a subtle head tilt.Order
Hira<neo> Early embryonic lethalityOrder
STOCK Hal<his>/H Hal<his> 10Coat Colour: Grey. Behaviour: Neurotic. Homozygotes, heterozygotes and wildtypes are not visibly distinguishable, but a urine test can rapidly screen wildtypes from homozygotes. HPLC quantification of histidine in urine can distinguish heterozygotes from homozygotes.Order From EMMA
129-Foxa2<tm1Jrt>/H Foxa2<tm1Jrt> 2Homozygous lethal at day 8 of gestation. This mouse strain has a pre-disposition to develop mis-aligned jaws which leads to over grown teeth.Order From EMMA
STOCK Hnf4a<tm1(cre)
Sdv>/H 		Hnf4a<tm1(cre)Sdv> 2Homozygous lethal at mid gestation due to defects in liver formation.Order From EMMA
Hnf4a 2
B6.Cg-Tlx1<tm1Thr>/H Tlx1<tm1Thr> 19Asplenia.Order From EMMA
Hox11 KO/unr5 Hox11 KO produces spleenless mice. uNR5 causes truncation (deletion of C1 and C2) of IgM H-chain.Order
Hoxa3<tm1(cre)Moon> Hoxa3<tm1(cre)Moon> 6Order
C3H101H-Gnrh1<hpg>/H Gnrh1<hpg> 14Order
Hprt Order
STOCK Aifm1<Hq>/H Aifm1<Hq> XOrder
C3H101H-Hr<hr>Ednrb<
s>/H 		Hr<hr> 14Hairless.Order
Ednrb<s> 14
HSA-Mini George Order
HSA-mini Grant Order
STOCK hsh/H hsh 3hind shakerOrder
HSP27 WT High Copy L
ine 		No phenotype in transgenic carriers.Order From EMMA
HSP27 WT Low Copy Li
ne 		No phenotype in transgenic carriers.Order From EMMA
HSP27 WT PrP Promote
r Line 		No phenotype in transgenic carriersOrder From EMMA
HT Gdf5<bp> 2Order
Bloc1s6<pa> 2
Mlph<ln> 1
C3H101H-Hum/H Heterozygotes have very dark stripe down the back, homozygotes very dark all over.Order
B6Dnk;B6N-Tnfaip1<tm
1a(EUCOMM)Wtsi>/H 		Tnfaip1<tm1a(EUCOMM)
Wtsi> 		11Potential EUMODIC data in the Europhenome database.Order From EMMA
C3H101H-Hw/H Hw Small at birth and weaning, waltzing and circling phenotype. Homozygotes probably die before birth. Heterozygotes have reduced viability between birth and weaning.Order
Hw UN
Igfn1_KD1 Order
IM Prnp 2Dilute brown coat.Order
C3H101H-In(1)5H White toes and spotting. Animals tend to be smallOrder
STOCK In(2)2H A<w> 2Phenotypic effect on agouti locus.Order
As 2
STOCK In(2)5Rk + + +
a<t>/+ Bloc1s6<pa> we Pax1<un> a<t>/H 		Bloc1s6<pa> 2The phenotype is black with a tan belly.Order
Pax1<un> 2
a<t> 2
we 2
we 2
STOCK In(5)9Rk/H Mlph<ln> 1Reduced fertility in both sexes.Order
In(5)9Rk 5
In(5)9Rk 5
STOCK In(X)1H/H In(X)1H XOrder
STOCK In(X)3H Eda<Ta> XOrder
Atp7a<Mo-blo> X
In(YLS)Lub(Y<m>) Order
B6Dnk;B6N-Cyb561<tm1
a(EUCOMM)Wtsi>/H 		Cyb561<tm1a(EUCOMM)W
tsi> 		11Potential EUMODIC data in the Europhenome database.Order From EMMA
C3H;C-INH17/H Trembler mutation with high stepping gait.Order From EMMA
C3H;C-INH18/H Trembler mutation with high stepping gait.Order From EMMA
C3H;C-Ta33Hl/H Ta33Hl XHeterozygous females are striped. Hemizygous males have no guard hairs, hair on tails, normal teeth, very little hair behind the ears. Homozygous females look like hemizygous males. Order From EMMA
Ta33Hl X
C3H;C-INH8/H Trembler mutation (poor inheritance).Order From EMMA
STOCK Invs<inv>/H Invs<inv> 4Homozygous embryos develop situs inversus.Order From EMMA
STOCK-Icst/H Pde6b<rd1> 5Abnormal gait, iris-corneal strands. Heterozygotes have variable eye phenotypes - corneal opacity/bulging, iris-corneal adhesion, irregular pupil, cataracts, some appear to have secondary glaucoma. May have poor penetrance.Order
Tyr<c> 7
Tyrp1<b> 4
Icst 2
STOCK Is(13;1)4H/H Is(13;1)4H 13Small at birth and weaning. Mutation originally thought to be a duplication of bands 1B1-C4 (Dp(1)13H), but later shown to be insertion of chromosome 13 bands B3-C1 into chromosome 1 at band A4. Heterozygous males are fertile; 8 out of 14 heterozygous females successfully bred and raised pups to weaning. Homozygotes have not been investigated.Order
STOCK Is(7;1)40H +
+/+ Hps5<ru2> Oca2<p>/H 		Hps5<ru2> 7There is no obvious phenotype and the males are sterile.Order
Oca2<p> 7
Is(7;1)40H 7
STOCK Is(In7;X)1Ct/H Is(In7;X)1Ct XOrder
C3H101HF1 x STOCK Is
(In7;X)1Ct Xic<a>/H 		Xic<a> XNon-random X-inactivation.Order
Is(In7;X)1Ct X
C3H101HF1 x STOCK Is
(In7;X)1Ct Xic<b>/H 		Xic<b> XOrder
Is(In7;X)1Ct X
B6;129-Isl1<tm1(cre)
Tmj>/H 		Isl1<tm1(cre)Tmj> 13Order
Isl1<tm1(cre)Sev> Isl1<tm1(cre)Sev> 13Order
STOCK a<18H>/H a<18H> 2Homozygotes are non-agouti with very dark pinna hairs. A/a<18H> looks wild-type. a/a<18H> look umbrous i.e. non-agouti with agouti hairs along side of body and on the belly.Order
STOCK Dnahc11<iv>/H Dnahc11<iv> 12Situs inversus viscerum.Order From EMMA
Tyrp1<b> 4
STOCk wccw/H wccw Wavy coat and curly whiskers. Not allelic with we (wellhaarig, MGI:98947), Tgfa<wa1> (MGI:1856388), Egfr<wa2> (MGI:1856397) or Pax1<un> (MGI:1856222). Allelism test with cw (curly whiskers, MGI:1856476) inconclusive.Order
wccw UN
C3H.Cg-Fbxo11<Jf>/H Fbxo11<Jf> 17Deaf.Order From EMMA
129P2/OlaHsd-Map3k1<
Gt(YTC001)Byg>/H 		Map3k1 13Full description available from Europhenome Order
STOCK Plp1<jp> x C3H
101HF1/H 		Plp1<jp> XOrder
Eda<Ta> X
Bloc1s6<pa> 2
Gdf5<bp-H> 2
Tyr<c> 7
Mlph<ln> 1
Dync1h1<Loa> 12
Xic<b> X
Hbb<d4> 7
Hbb<d> 7
JPX/H Order
B6.A-Ush1g<js>/JH Ush1g<js> 11Deafness.Order
JU/FaCt-+<a> +<c> Order
Ju/FaCt-+<c> Order
C3H.C-Mecom<Jbo>/H Mecom<Jbo> 3Late onset deafness, extra digit, reduced body weight, craniofacial defect.Order From EMMA
Tyr<c> 7
Pde6b<rd1> 5
Tyrp1<b> 4
129S2.Cg-Tg(KRT10-Ig
fr2*)KippsGfc/H 		Tg(KRT10-Igfr2*)Kipp
sGfc 		Slightly reduced overall body weight, disproportionate reduction in size of alimentary canal and uterus.Order From EMMA
C.Cg-Krt10<tm1Tmm>/H Krt10<tm1Tmm> 11K10T mice show a phenotype in the epidermis and in tongue, esophagus and forestomach. Homozygous pups die on the first day after birth from dehydration due to generalised blistering within the epidermis. Heterozygous mice look normal at birth and develop a progressive thickening of the skin and hyperkeratosis. Their skin is scaly. Heterozygotes breed normally. Order From EMMA
B6;129P2-Kcnj15<tm1D
gen>/H 		Kcnj15<tm1Dgen> 16Kir4.2 potassium channel knockout. Phenotype as yet undetermined Order From EMMA
B6;129-Khk<tm1Dtb>/H Khk<tm1Dtb> 5Not assessed.Order
STOCK Khk<tm1.1Dtb>/
H 		Khk<tm1.1Dtb> 5No visible phenotype.Order
B6;129-Khk<tm2Dtb>/H Khk<tm2Dtb> 5Order
STOCK Khk<tm2.1Dtb>/
H 		Khk<tm2.1Dtb> 5Not assessed.Order
STOCK Kit<W-19H>Y<AK
R>/H 		Kit<W-19H> 5dominant spottingOrder
CBA/H-Kit<W-27H>/H Kit<W-27H> 5Dominant spotting.Order
C3H.Cg-Kit<W-28H>/H Kit<W-28H> 5Dominant spotting.Order
C3H.Cg-Kit<W-29H>/H Kit<W-29H> 5Dominant spotting.Order
C3H101H-Kit<W-30H>/H Dominant spotting.Order
C3H101H-Kit<W-31H>/H Kit<W-31H> 5Dominant spotting. Kit<W-31H>/+: white feet, belly spot, head spot, greying of coat. Kit<W-31H>/Kit<W-31H>: black-eyed, white fur.Order
Kit<W-32H> Kit<W-32H> 5Dominant spotting. Kit<W-32H>/+: white feet, belly spot, head spot, greying of coat. Kit<W-32H>/Kit<W-32H>: black-eyed, white fur.Order
Kit<W-33H> Dominant spotting.Order
C3H101H-Kit<W-36H>/H Kit<W-36H> 5Dominant spotting.Order
C3H101H-Kit<W-38H>/H Kit<W-38H> 5Dominant spotting Kit<W-38H>/+: spotting on head, back and belly. Kit<W-38H>/Kit<W-38H>: black-eyed, white coat.Order
C3H101HF1 x STOCK Ki
t<W-bd>/H 		Kit<W-bd> 5White band in trunk region.Order From EMMA
C3H101H-Kit<W-ct>/H Kit<W-ct> 5Cattanach's dominant spottingOrder
C3H.Cg-Kit<W-e>/H Kit<W-e> 5Heterozygotes have coat spots. Homozygosity is lethal.Order From EMMA
C3H101HF1 x STOCK Ki
t<W-sh> Fgf5<go> Vps33a<bf>/H 		Kit<W-sh> 5Sash.Order
Fgf5<go> 5
Vps33a<bf> 5
Kit<W-sh>l Kit<W-sh> 5Order
B6.Cg-Kit<W-v>/H Kit<W-v> 5Viable dominant spottingOrder
C3;CAnNCrl-Kit<W-39H
>/H 		Kit<W-39H> 5Heterozygotes have a white belly spot and occasionally a white head blaze. Homozygotes have not been identified and they may die in uteroOrder
129S/SvEv-Klf13<tm1C
oll>/Coll 		Klf13<tm1Coll> 7Mice show altered T, B cell & erythroblast differentiation.Order From EMMA
C57BL/6NTac-Klhdc2<t
m1a(EUCOMM)Hmgu>/H 		Klhdc2<tm1a(EUCOMM)H
mgu> 		12Potential EUMODIC data in the Europhenome database. Order From EMMA
C3H.Cg-Koa/H In(15)4H 15Heterozygotes have hairy ears and muzzle, homzygotes are slightly more extreme.Order
B6.129-Krt36<tm1Hpt>
/H 		Krt36 11Hyperkeratosis of scales (tail) and filiform papillae (tongue). The analyses are not yet complete but if present, the phenotype is very weak in heterozygotes. An obvious hyperkeratosis is however apparent in homozygous mutant animals.Order From EMMA
B6Dnk;B6N-Fam117b<tm
1a(EUCOMM)Wtsi>/H 		Fam117b<tm1a(EUCOMM)
Wtsi> 		1Potential EUMODIC data in the Europhenome database.Order From EMMA
C3H101H-Sox2<lcc>/H Sox2<lcc> 3Light coat circler.Order
In(3)9H 3
C3H;101H-Sox2<lcc>/H
Wtsi [cc] 		Sox2<lcc> 3Homozygotes show head bobbing and circling behaviour, deafness and a pale yellow coat colour. Hets occasionally have a very mild head bob and a slightly diluted coat colour, but this is very difficult to see robustly.Order From EMMA
In(3)9H 3
Lct Slc45a2<Ltct> 15Mutation: light coat. Heterozygotes look similar to c<ch>/c<ch>: white pinna hairs and a slate grey-like coat. Homozygotes are thought to have a fawn coloured coat and ruby eyes; this needs to be confirmed as other recessive mutations affecting coat colour may be segregating in the stock. Both heterozygotes and homozygotes are fully viable and fertile. Allelism tests with Slc45a2<uw> gave no recombinants with 484 offspring scored, therefore light coat is considered to be an allele of Slc45a2.Order
C3H;C-Lcl/H Lcl Lens cloudy. Cataracts. Mice heterozygous for this mutation show progressive cataract formation, with total opacity at approximately 3 months. Mice homozygous for this mutation have small eyes and total lens opacity at 4-5 weeks.Order From EMMA
STOCK Rb(6.15)1Ald M
ip<Cat-Lop>/H 		Tyr<c> 7Lens opacity.Order
Mip<Cat-Lop> 10
C3;C-Pax6<Leca1>/H Pax6<Leca1> 2Heterozygotes have a central indentation and may have small eyes, irregular pupils and lens corneal adhesionsOrder From EMMA
C3H;C-Pax6<Leca2>/H Pax6<Leca2> 2Heterozygotes have small eyes, corneal opacities and cataracts.Order From EMMA
C3;C-Pax6<Leca3>/H Pax6<Leca3> 2Mutants may have central corneal opacity, small eyes, dilated pupils and lens-corneal adhesion. Order From EMMA
STOCK Li/H Li XLined. Li/Y embryos are outwardly similar to +/Y at 9.5 dpc, but by 10.5 dpc are markedly smaller and some are dead; all die before birth. Li/+ are about 10% smaller than +/+ sibs at birth, and about 5% smaller at weaning. About one quarter of Li/+ are lost prior to birth. Typicaly, Li/+ can be identified by day 10 after birth by dark stripes on the coat. Li has been shown to be a deletion of less than 0.7 cM which encompasses Rps6ka3 and as such, may be a model for Coffin-Lowry syndrome (Blair et al HMG, 1998, 7, 3, 549-555).Order
LII Mcoln3<Va> 3Order
Gli3<Xt> 13
T 17
LIII Cdh23<v> 10Order
Mlph<ln> 1
Hps1<ep> 19
Sgk3<fz> 1
STOCK Lhx1<tm1Bhr>/H Lhx1<tm1Bhr> 11Homozygous lethal at day 10 of gestation.Order From EMMA
Line # 46 - Fused lo
be 		Order
Line # 48b - Unbranc
hed 		Fusion of cranal and medial lung lobes; kidneys are small, lack medulla; lacrimal glands have less epithelium branchingOrder
LIVA Tyrp1<b> 4Order
Tgfa<wa1> 6
Tyr<c-ch> 7
Myo5a<d> 9
Bmp5<se> 9
Ednrb<s> 14
a 2
LL Bloc1s6<pa> 2Limb - short legs and digits affected.Order
Mlph<ln> 1
Gdf5<bp-H> 2
LMWP3 Low Molecular Weight Protein (LMWP) in the urine which is an indicator of proximal tubule dysfunction in the kidney.Order
Lnk -/- Order
Lo Moe None. Order From EMMA
C3H;101H-Dync1h1<Loa
>/H 		Dync1h1<Loa> 12Legs at odd angle.Order From EMMA
C3H;B6-Col2a1<Lpk>/H Col2a1<Lpk> 15Short-limbed phenotype in both fore- and to a lesser extent hind-limbs. Spondyloepiphyseal dysplasia congenita (SEDC) with secondary osteoarthritis.Order From EMMA
C.Cg-Col2a1<Lpk>/H Col2a1<Lpk> 15Short-limbed phenotype in both fore- and to a lesser extent hind-limbs. Spondyloepiphyseal dysplasia congenita (SEDC) with secondary osteoarthritis. Order
STOCK Vangl2<Lp>/H Vangl2<Lp> 1Ltap<Lp>/+ mice exhibit a tail defect. Ltap<Lp>/Ltap<Lp> mice exhibit severe neural tube defect (die at birth).Order
STOCK Lop4/H Lop4 2Lens opacity.Order
STOCK Lop6/H Lop6 Lens opacityOrder
STOCK Lop9/H Lop9 Order
B6;129P2-Lphn2<tm1Dg
en>/H 		Lphn2<tm1Dgen> 3NoneOrder From EMMA
LR8 Hps6<ru> 19Order
Gdf5<bp> 2
Bmp5<se> 9
Hps5<ru2> 7
Myo5a<d> 9
a 2
Oca2<p> 7
Hps1<ep> 19
LRIG 3 (KOL3) Lrig3 10Unknown.Order From EMMA
ls<rrw> Homozygotes usually die before weaning but have a predominantly white coat with pigmental rump.Order
B6Dnk;B6N-Ttll4<tm1a
(EUCOMM)Wtsi>/H 		Ttll4<tm1a(EUCOMM)Wt
si> 		1Potential EUMODIC data in the Europhenome database.Order From EMMA
LVC Egfr<wa2> 11Jerker, homozygotes exhibit jerky behaviour. Spontaneous. waved 2, homozygotes have wavy fur. Spontaneous. pe<H>, homozygotes have a light coat. Spontaneous. mahoganoid, homozygotes have a dark coat. Spontaneous.Order
Espn<je> 4
Mgrn1<md> 16
LVI Toes fused,(8) black coat,(8) belly spots,(10) light coat,(10) behavioural (18)Order
B6(Cg)-Klra5<tm1.1Cg
br>/H 		Klra5<tm1.1Cgbr> 6Lack of expression of Ly49E. Expression of b-geo. No other known phenotype at present.Order From EMMA
M1073B Embryonic lethal.Order From EMMA
M1185B Foxq1<sa> 13Embryonic lethalOrder From EMMA
M1239B Foxq1<sa> 13Embryonically lethalOrder From EMMA
M1616B Foxq1<sa> 13Embryonic lethal.Order From EMMA
M1645B Foxq1<sa> 13Embryonic lethal.Order From EMMA
M241B Foxq1<sa> 13Embryonic lethal - not fully penetrant. Forebrain truncation abnormality.Order From EMMA
M369B Foxq1<sa> 13Embryonic lethalOrder From EMMA
M412B Foxq1<sa> 13Embryonic lethal.Order From EMMA
STOCK M54B/H Embryonic lethal, not fully penetrant. Possible craniofacial abnormality. Mice at weaning and when adults including the sa mice which have survived have no obvious visible phenotype.Order From EMMA
M624B Foxq1<sa> 13Embryonic lethalOrder From EMMA
M876B Foxq1<sa> 13Embryonic lethal in a Mut sa/++ (heterozygous) intercross. Line is not an embryonic lethal when crossed to the Del36H deletion.Order From EMMA
STOCK ma-Mcoln3<Va>/
H 		ma 3Mcoln3<Va> heterozygotes are deaf mice that have variegated coats, they also circle and/or headtoss. ma/ma mice have scruffy coats. Order
Mcoln3<Va> 3
C3H101H-Maf<tm1Glm>/
H 		Maf<tm1Glm> 8Homozygotes have eye defects, are small and shaky, and may die before adulthood.Order
C3.Cg-Maf<Ofl>/H Maf<Ofl> 8Heterozygotes-opaque flecks in lens; homozygotes- very small eyes, most die at birth through failure to feed, survivors small, trembly, and develop nephritis. Dominant cataractOrder
STOCK Maf<Ofl>/H Maf<Ofl> 8Order From EMMA
Mafb<Krml-kr>;we; (K
reisler) 		we 2Order
Mafb<kr> 2
129P2/OlaHsd-Mkrn1<G
t(RRB087)Byg>/H 		Mkrn1<Gt(RRB087)Byg> 6No abnormal phenotype detected. Order
TgN(DSPM36)1886OxAna
t 		Order
Math1-Bmi1 (Cross 2) Order From EMMA
TgN(DSPM36)1892OxAna
t 		Order
MB Order
C3H;B6-MBT1/H Lack of marble burying. Mutant mice fail to bury marbles in sawdust when left for a period of 30 minutes. Order From EMMA
C3H;B6-MBT2/H Low anxiety, marble mutant.Order From EMMA
C3H;B6-MBT3/H Low anxiety, marble mutant.Order From EMMA
C3H;B6-MBTR2/H Lack of marble burying.Order From EMMA
C3;B6-MBTR3/H Lack of marble burying.Order From EMMA
MC-1 Microchromosome (Mc-1): carriers are ostensibly phenotypically normal. However, males carrying 1 copy of Mc-1 are infertile or have seriously reduced fertility: sperm counts are severely reduced and a high proportion of the sperm are structurally abnormal. Females carrying one copy of Mc-1 are fertile. Crosses of carrier females (with one copy of Mc-1) to 3H1 males generated 27 wild-type offspring, 37 with one copy and one with two copies of Mc-1. Carriers were identified by karyotyping lymphocyte cultures from whole blood.Order
B6;129P2-Mc2r<tm1Dge
n>/H 		Mc2r<tm1Dgen> 18No visible phenotype.Order From EMMA
STOCK Dmd<mdx> Tg(Ck
m-Dmd_iDp71)MCA-1Chmb/H 		Dmd<mdx> XOrder From EMMA
Utrn<tm1Ked> 10
Tg(Ckm-Dmd_iDp71)MCA
-1Chmb
Tg(Ckm-Dmd_iDp71)MCA
-1Chmb 		UN
B;CBACa-Dmd<mdx>Tg(C
KMM-tTA)A3Rhvh/H 		Tg(CKMM-tTA)A3Rhvh MCK-tTA/mdx mice contain the muscle specific creatine kinase (MCK) promoter driving the tetracycline regulated transactivator (tTA).Order From EMMA
Dmd<mdx> X
Mcpt1<tm1Hrpm> Mcpt1<tm1Hrpm> 14Lack of Mcpt-1 expression.Order
C3H101H-Mgrn1<md-nc>
/H 		Mgrn1<md-nc> 16Non-agouti with black pinna hairs and curly whiskers. Breeding data obtained from homozygous males crossed to heterozygous females suggest that nearly 50% of homozygotes are lost prior to birth, with an average litter size at birth of over 5 on a mixed genetic bsckground. Survival of homozygotes from birth to weaning is good. Mgrn1<md-nc>/Mgrn1<md> have straight whiskers, umbrous coats and ears that are darker than wild-type.Order
C57BL/10ScSn-Dmd<mdx
>/KedH 		Dmd<mdx> XX-linked muscular dystrophy.Order
STOCK Dmd<mdx-3Cv>/H Dmd<mdx-3Cv> XOrder
129S5.Cg-Med31<l11Ju
s15> +/+ In(11Trp53;11Wnt3)8Brd/H 		Med31<l11Jus15> 11Embryonic lethality with reduced cell proliferation rates in embryonic fibroblasts.Order From EMMA
In(11Trp53;11Wnt3)8B
rd 		11
B6;CB-Mesp1<tm2(cre)
Ysa>/H 		Mesp1<tm2(cre)Ysa> 7Order
C3;C-Chd7<Mt>/H Tyrp1<b> 4Heterozygotes exhibit head weaving and circling behaviour. Homozygotes exhibit midgestational lethality possibly due to vascular defects seen in the anterior neural tube.Order From EMMA
Pde6b<rd1> 5
Tyr<c> 7
Chd7<Mt> 4
C3H101H-Kitl<Sl-10H>
/H 		Kitl<Sl-10H> 10steelOrder
C3H101H-Del(10)1H/H Del(10)1H 10steel. Known to be a deletion (Del(10)1H) see Cattanach et al Nat Genet 1993, 3 (1):56-61.Order
Del(10)1H 10
C3H101H-Kitl<Sl-13H>
/H 		Kitl<Sl-13H> 10Kitl<Sl-13H>/+: greyish coat, occasional head and belly spot, half white feet and tail. Kitl<Sl-13H>/Kitl<Sl-13H>: lethal, black eyed white dying a few days after birth.Order
C3H101H-Kitl<Sl-14H>
/H 		Steel.Order
C3H101H-Kitl<Sl-15H>
/H 		Kitl<Sl-15H> 10Kitl<Sl-15H>/+: greyish coat, occasional head and belly spots, half white feet and tail. Kitl<Sl-15H>/Kitl<Sl-15H>: black eyed white dying a few days after birth.Order
C3H101H-Kitl<Sl-17H>
/H 		Kitl<Sl-17H> 10Steel.Order
C3H101H-Kitl<Sl-18H>
/H 		Kitl<Sl-18H> 10steelOrder
C3H101H-Kitl<Sl-20H>
/H 		Del(10)8H 10Steel.Order
C3H101H-Kitl<Sl-21H>
/H 		Kitl<Sl-21H> 10Kitl<Sl-21H>/+: grey fur, head and belly spot, white feet and tail. Kitl<Sl-21H>/Kitl<Sl-21H>: anaemic, die before weaning.Order
STOCK Kitl<Sl-22H>/H Del(10)12H 10Steel.Order
C3H101H-Kitl<Sl-23H>
/H 		Del(10)9H 10Steel.Order
C3H101HF1 x STOCK De
l(10)13H/H 		Del(10)13H 10Steel.Order
C3H101H x STOCK Kitl
<Sl-25H>/H 		Kitl<Sl-25H> 10steelOrder
C3H101H-Kitl<Sl-26H>
/H 		Kitl<Sl-26H> 10Kitl<Sl-26H>/+: steel, greyish fur, pale feet and tail with occasional head dots and belly spots, anaemia. Homozygotes not investigated.Order
Kitl<Sl-27H> Kitl<Sl-27H> 10Kitl<Sl-27H>/+: steel, greyish fur, pale feet and tail with occasional head dots and belly spots. Kitl<Sl-27H>/Kitl<Sl-27H>: prenatal lethal.Order
C3H101H-Kitl<Sl-29H>
/H 		Kitl<Sl-29H> 10Heterozygotes have typical steel phenotype: greyish fur, pale feet and tail with occasional head dots and belly spots. Homozygotes: black-eyed whites, anaemia, no survival past a few days after birth.Order
C3H101H-Kitl<Sl-30H>
/H 		Kitl<Sl-30H> 10Kitl<Sl-30H>/+: steel, greyish fur, pale feet and tail with occasional head dots and belly spots. Kitl<Sl-30H>/Kitl<Sl-30H>: die early post implantation.Order
C3H101H-Kitl<Sl-31H>
/H 		Kitl<Sl-31H> 10Kitl<Sl-31H>/+: steel, greyish fur, pale feet and tail with occasional head dots and belly spots, anaemia. Kitl<Sl-31H>/Kitl<Sl-31H>: lethal, die pre or perinatally.Order
C3H101H-Del(10)77H/H Del(10)77H 10Steel, greyish fur, pale feet and tail with occasional head dots and belly spots, anaemia, high pre-implantation loss - homozygotes die early in development, some live foetuses were also anaemic. Found to be deletion on Chr10 (cytoband D1).Order
C3H101H-Kitl<Sl-33H>
/H 		Kitl<Sl-33H> 10Kitl<Sl-31H>/+: steel, greyish fur, pale feet and tail with occasional head dots and belly spots. Anaemia. Homozygote not investigated.Order
Mgf<Sl-34H>, T(19;11
)75H 		Order
C3H101H-Kitl<Sl-8H>/
H 		Kitl<Sl-8H> 10Order
C3H101H-Kitl<Sl-9H>/
H 		Kitl<Sl-9H> 10steelOrder
C3H101HF1 x STOCK Ki
tl<Sl-pan>/H 		Kitl<Sl-pan> 10Steel-panda.Order
C3H101HF1 x STOCK cw
-Bmp5<se>tk/H 		cw 9Kinky tail.Order
tk 9
Bmp5<se> 9
C3H;C-Mitf<Mi-H>/H Mitf<Mi-H> 6Microphthalmia. Dominant mutant with small eyes, Mi-like. Heterozygotes are paler, they have head and belly spots. Homozygotes are white with no eyes. Order
B6N;B6J-Tyr<c-Brd> M
ier1<tm1a(EUCOMM)Wtsi>/WtsiH 		Mier1<tm1a(EUCOMM)Wt
si> 		4Potential EUMODIC data in the Europhenome database.Order From EMMA
Mitf<Mi-wh>, px Mitf<Mi-wh> 6het. light coated & light ears & sometimes a belly spot. hom. Mitf<Mi-wh> white with slight micropthalmia, Forelimbs often affected with absence of digets & sometimes ulna. Large foramen in scapula. All feet have epidermal papillae etc.Order
Wnt7a<px> 6
C3H;C-Tyr<c-ch62H>/H Tyr<c-ch62H> 7c<62chH>/c<62chH> homozygotes have a grey coat colour, c/c<62chH> trans-heterozygotes have a cream coat colour and ruby coloured eyes. Order From EMMA
C3H101H-Minute/H Minute 7Minute.Order
MOD Fused Toes Syndactyly.Order
TgN(DSPM36)1892OxAna
t 		Order
C3H;C-Mtu/H Mtu 12Kinky tail, deaf, belly spot. Heterozygotes exhibit abnormal tail morphology, are deaf, and have belly spots that are characteristic of neural crest defects. Homozygotes, do not appear to be viable, as they have an open neural tube. Order From EMMA
C3H101H-Mdh1<am1H>/H Mdh1<am1H> 11Order
TgN(DSPM36)1327OxAna
t 		Order
C57BL/6NTac-Mpi<tm1a
(EUCOMM)Wtsi>/H 		Mpi<tm1a(EUCOMM)Wtsi
> 		9Potential EUMODIC data in the Europhenome database.Order From EMMA
MR Albino, rough kinked whiskers.Order
C57BL/6Apb-Zap70<mrt
le>/Apb 		Zap70<mrtle> 1Identified by severe reduction in T cell numbers in blood. Zap70 protein expression of mrt/mrt thymocytes was 25% of +/+ thymocytes. Het mice, mrt/+ have normal levels of CD4+ and CD8+ thymocytes but Zap70 protein expression is two-fold lower.Order From EMMA
B6.129P2-Mro<tm1H>/H Mro<tm1H> 18No visible phenotype.Order
C3H.Cg-Mfl/H Order
MUHi Long term growth selected line.Order
MULi Long term growth selected mouse line.Order
MURB125 Limbs and bones are shorter than normalOrder
MURB151 Heterozygotes have light grey coat , darker grey points on ears, nose and tail. Can be classified at 2-3 days old as the pigmentation of the skin is visibly different.Order
CAST/EiJH Order
SPRET/EiJH A<w> 2Order
STOCK Mut1045/H Mut1045 Affected heterozygotes are small at birth and estimated to be circa 30% lighter than wild-type sibs of the same gender by weaning. Breeding data suggest that viability is over 50% to weaning, but penetrance of the mutation is reduced. Opening data indicate homozygotes are lethal by early post implantation. Average litter size from heterozygous females is reduced. Cytogenetics: no obvious chromosomal abnormality detected.Order
STOCK Mut1048/H Mut1048 Heterozygotes are small at birth and weaning, have short kinky tails and white hind feet. Opening data suggest that circa one quarter of Mut1048/+ are lost post implantation and that penetrance of the mutation is roughly 75%. Viability of heterozygotes between birth and weaning appears much higher from outcrosses from heterozygous females to 3H1 males (34/35) than from the reciprocal (70/119). Most, if not all, homozygotes are probably lost pre-implantation. Linkage data showed no evidence of linkage of Mut1048 to: a, Tyrp1<b>, Oca2<p>, Tyr<c-ch>, Myo5a<d>, Bmp5<se> and Ednrb<s>. Mut1048 has been shown to not be allelic with T. Cytogenetics: no obvious chromosomal abnormality. Mut1048 has phenotypic similarities with Rpl24<Bst> (MGI:1856685, Chr16, 33.74cM). Linkage data with Mgrn1<md> (Chr16, 2.48cM) gave 32/82 recombinants (39.0cM +/-5.4cM), indicating that Mut1048 may be an allele of Rpl24.Order
STOCK Mut1064/H Mut1064 Small at birth and weaning with head bobbing. Affected heteroygotes are approximately 50% of the weight of their gender matched wild-type sibs at weaning. Although breeding data show a circa 30% loss of pups between birth and weaning from 3H1 female x het male matings, the data also suggest that viability of Mut1064/+ and penetrance of the mutation are relatively good. Heterozygous females have been shown to be fertile, but be very poor mothers. Opening data indicate loss of some, if not all, homozygotes before implantation.Order
STOCK Mut1083/H Mut1083 Heterozygotes small at weaning with head bobbing, but phenotype can be quite subtle. Breeding data suggest that about 50% of Mut1083/+ survive to weaning on a 3H1 background. One offspring reported to have inversion of bands A2 to B2 on Chr5, but not confirmed to be consistent with head bobbing phenotype. Breeding and opening data suggest that homozygotes are lost prior to birth - possible pre-implantation lethality, but confirmation required.Order
STOCK Mut1091/H Mut1091 Heterozygotes: small at birth and weaning with possible behavioural abnormalities. Breeding studies suggest that Mut1091/+ can be identified at birth by reduced size - on average 70% of the weight of wild-type littermates. A similar reduction in weight is seen at weaning with gender-matched +/+ sibs. Opening data indicate that homozygotes die by early post implantation.Order
STOCK Mut1096/H Heterozygotes: small with broad, domed head. Opening data indicate some pre-natal loss including raised incidence of exencephaly, suggesting that circa 50% of hets die prior to birth. Average litter size from outcrosses to 3H1 are in accord with this estimate of pre-natal loss. Mut1096/+ are more than 30% smaller than wild-type gender matched sibs at weaning. Ratio of dome-headed offspring to wild-type at weaning is about 1:6, indicating reduced viability of Mut1096/+ after birth and/or reduced penetrance of the mutant phenotype. The high level of pre-weaning loss would suggest the former as being the bigger factor. Homozygotes: probably lost pre-implantation.Order
STOCK Mut1139/H Mut1139 Heterozygotes: shortened kinky tail with white feet. Breeding data indicate that penetrance is variable: circa 90% on crosses of 3H1 males to Mut1139/+ females, but lower from the reciprocal matings. No affected pups (out of 42 scored) were seen from Mus castaneus females x Mut1139/+ males. Viability of affected pups to weaning is good (over 80% survival recorded from above 3H1 crosses. Weight data are variable, but indicate that Mut1139/+ are smaller on average (circa 20%) than normal littermates at birth and weaning. Homozygotes: opening data strongly suggest death by early post implantation. Mapping: shown not to be an allele of T, nor a deletion encompassing tf or qk. No evidence of linkage with ma, Tyrp1<b> or Bmp5<se>. Taking data from pups showing Mut1139/+ phenotype only: suggestion of linkage to Egfr<wa2> (11 recombinants out of 32 pups). Cytogenics: no obvious chromosomal aberration detected.Order
STOCK Mut1152/H Mut1152 Homozygous early post-implantation lethal. Heterozygotes are small (circa 20% smaller than wild-type littermates at weaning) with cranial doming, pop eyes, distal nasal bone with occasional indications of cleft; many have stripe on nose.Order
STOCK Mut1154/H Mut1154 Small at birth and small at weaning with cranial doming, variably wide between eyes and shortened nasal passage. Very limited weight data, but heterozygotes estimated to be 15% smaller than wild-type sibs at weaning. Not deaf. Cytogenetics: no obvious gross chromosome abnormality detected.Order From EMMA
C3H101H x STOCK Mut1
170/H 		Mut1170 Heterozygotes have a very short tail (very occasionally with spina bifida), but no reduction in body size. Viability to birth and penetrance of the mutation is high; viability between birth and weaning is about 55% on a mixed genetic background. Breeding data show a tendency for a higher proportion of heterozygotes to be born from outcrosses of heterozygous males than from reciprocal matings (chi squared test, p = 0.031). Homozygotes die as small moles. Cytogenetics: no obvious chromosomal abnormality detected.Order
Mut1170 UN
STOCK Mut1264/H Mut1264 Craniofacial and behavioural mutant with distal low degree tail kink. Homozygous pre-implantation lethal. Heterozygotes have a flat skull, short, blunt tails with a low degree distal kink and some have white feet. Behavioural abnormalities include head bobbing and erratic behaviour but they can swim. Heterozygotes are approximately 30% smaller than wild-type sibs at birth and weaning. High incidence of exencephaly in fetuses.Order From EMMA
STOCK Mut1275/H Mut1275 Heterozygotes show asymmetry in lop-ear phenotype. From outcrosses of heterozygotes, where the affected ear was recorded, there were 21 left ear and 3 right lop-ear offspring, intercrosses of hets gave 19 left and 0 right lop-ear offspring. Penetrance of the lop-ear phenotype is poor - about 25% if assuming no lethality. White feet (approx. 50% penetrance) and small size have also been shown to be part of the phenotype. Mice with white feet were shown to be approx 20% lighter than gender matched wild-type looking sibs at birth and weaning. Breeding data suggest that homozygotes are lethal prenatally.Order
STOCK Mut1293/H Mut1293 Heterozygotes are small at birth and weaning. Broad head, bulging eyes, some have ear problems i.e. a build up of a hard white deposit and signs of blood. Penetrance of the phenotype and viability of affected individuals to weaning is good. Homozygotes die post implantation, or survive for longer but are oedematous and have skeletal bone/cartilage abnormalities; limited intercross data suggest that they do not survive post-natally.Order From EMMA
STOCK Mut1305/H Mut1305 Small with white toes; sometimes with domed head. Affected heterozygotes are, on average, circa 30% smaller than normal littermates at birth, and about 20% smaller at weaning. Many have white toes; about 15% of affected mice have a noticeably domed head at weaning. Litter sizes are good, suggesting little pre/peri-natal loss of heterozygotes and thus penetrance of mutation phenotype is about 80%. Viability to weaning is about 70%. Homozygotes: data from openings strongly suggest that they die by early post implantation.Order From EMMA
STOCK Mut1397/H Mut1397 Heterozygotes: shortened tail with mild to severe kinking and blunt tail tip. Homozygous lethal. Heterozygotes: viability good, but reduced penetrance of phenotype on crossing to 3H1 (circa 70%), much more reduced on crossing to Mus castaneus. Opening and breeding data indicate that homozygotes are lost pre and early post-implantation. Allelism test with t<h2> (MGI:1856184) showed Mut1397 not to be an allele of T (MGI:1856184).Order From EMMA
STOCK Chy10/H Chy10 Mutation causes typical chylous ascites-like symptoms - milky abdomen at birth and puffy feet and tail in older animals. From crosses of 3H1 females to heterozygous males, under 40% of the offspring exhibit the milky abdomen phenotype, of these approx 40% survived through to weaning age.Order
STOCK Mut1446/H Mut1446 Affected heterozygous offspring develop pus filled spots on head and/or body - visible by one week of age. (Is this a model of Behcet disease?). A degree of fur-loss is also common. Mut1446/+ are of normal weight at birth, but by weaning are approximately half the weight of gender matched wild-type sibs. Data from openings indicate that homozygotes are lost by early post implantation, with a large proportion dying pre-implantation.Order
Mut1446 UN
STOCK Mut1454/H Mut1454 Small at birth and weaning, white feet, short kinky tail. Some have odd behaviour - swaying, leaning, head bobbing. Heterozygotes: opening data suggest that a proportion are lost post implantation; breeding data indicate reduced penetrance of the mutation and about 50% viability of affected pups between birth and weaning; limited weight data indicate a circa 40% weight reduction at birth and slightly greater loss by weaning compared to wild-type sibs. Homozygotes probably die pre-implantation.Order
STOCK Mut1477/H Chy11 Milky abdomen at birth, small at weaning but no puffy feet and tail. From crosses of heterozygous males to 3H1 females, only about 10% of offspring exhibit the milky abdomen phenotype - viability of these to weaning age is good.Order
STOCK Mut1488/H Mut1488 Heterozygotes are less than 75% of the weight of their wild-type sibs at birth; limited weight data at weaning suggest that there is a similar size difference at this time point. Mut1488/+ have small eyes, occasionally with domed heads, some have white toes. Breeding data indicate that there is reduced penetrance of the mutation (circa 50%) on a 3H1 background. Data from openings indicate that homozygotes are lost soon after implantation.Order From EMMA
Mut1488 UN
STOCK Mut1490/H Chy12 Mutation causes typical chylous ascites-like symptoms - milky abdomen at birth, and puffy feet and tail in older animals. From crosses of 3H1 females to heterozygous males, under 40% of the offspring exhibit the milky abdomen phenotype, of these, about two thirds survived through to weaning.Order
STOCK Mut1544/H Mut1544 Heterozygotes have a bruised appearance at birth with bloody areas beneath the skin, most common around the belly and abdomen, some around the neck and back legs. Most also have a domed head. Penetrance of the mutation is slightly reduced, but estimated to be over 70%. Affected offspring are about 20% lighter than normal sibs at birth, and about 35% lighter than wild-type gender matched sibs at weaning. Viability of affected offspring between birth and weaning is estimated to be about 75%. Average litter size of heterozygous females is reduced (estimate: 4.9). Homozygotes: opening data indicate that they probably die by early post implantation, with a large proportion dying pre-implantation.Order From EMMA
Mut1544 UN
STOCK Mut1556/H Mut1556 Heterozygotes are small, with white feet, some have a belly spot. A proportion also display head bobbing and have a kinked and/or blunt tail. Limited weight data indicate that heterozygotes are approximately two thirds of the weight of their wild-type sibs at birth and have a similarly weight reduction at weaning. Breeding data suggest that the penetrance of all aspects of the phenotype is reduced (to perhaps circa 30%) on a 3H1 background. Homozygotes probably die pre-implantation.Order
Mut1556 UN
STOCK Mut1602/H Mut1602 Heterozygotes are small at birth (over 40% lighter than wild-type sibs) and weaning with white hind feet, short tail and head bobbing. Breeding data suggest that penetrance of the mutation is reduced (circa 65%) and that under 60% survive between birth and weaning. Homozygotes are primarily lost post implantation. There is little or no loss of heterozygotes prior to birth.Order From EMMA
Mut1602 UN
STOCK Mut1679/H Heterozygotes have white feet, shorter kinky tails. Some have domed heads and display head bobbing. There is evidence of occasional nasal cleft. Weight data indicate that Mut1679/+ are about 30% lighter than their wild-type sibs at birth and similarly, if not more severely, reduced in size at weaning. Data from openings indicate that a proportion of heterozygotes are lost both pre- and post implantation; homozygotes are probably lost prenatally. Breeding data suggest that penetrance of Mut1679 is good and that viability from birth to weaning is high.Order
MUT1681 Small with white feet. Tails commonly severely shortened, kinked or curled. Some have broad, deep, short head, often with nasal stripeOrder
C3H101HF1 x STOCK Mu
t1696/H 		Small in size with head bobbing. Heterozygotes are small at birth and weaning with head bobbing. Size and behavioural mutation. Unlikely homozygotes survive as evidence of pre implantation loss. Best bred through the male as the females behaviour makes them poor carers for their young.Order
STOCK Mut1704/H Small at birth and weaning. Domed/pointy heads, some with fused toes.The original female was small at birth and weaning with fused hind toes, slightly domed head, whitish toes and tail tip. The offspring phenotype varied, many were small, the fusing of toes only involved the soft tissue not bone. These embryos were generated by IVF with MUT/1704.3d male; small with kink in tail at birth. Small and runty at weaning with dark coat, pointy face and closed eyes.Order
STOCK Mut1756/H Offspring look normal until 6 weeks when fur becomes sparse, and thus classification prior to 6 weeks not possible in heterozygotes. Small at birth and weaning. Fate of homozygotes not yet determined.Order
STOCK Mut495/H Mut495 10MUT495 has various phenotypic effects such as darkening of the coat, black foot pads and genitalia, white hind toes, dark tail. Linkage data place Mut495 23 cM +/- 3.75 cM from Sl<con>.Order
STOCK Mut549/H Mut549 Shortening and/or kinking of the tail, white hind feet, shortened snout, smaller than wild-type sibs at birth. Breeding data suggest penetrance of phenotype is circa 50%. Viability of affected pups to weaning is about 80%. Homozygotes not investigated.Order
STOCK Mut579/H Mut579 Affected heterozygotes: squint jaw, short snout, small eyes. Breeding data suggest that: heterozygotes have reduced penetrance (circa 30% on 3H1 background) and good viability to weaning; homozygotes are lost pre-natally (opening data showed that death is probably early post-implantation).Order
STOCK Mut607/H Mut607 Cytogenetic studies suggested possible proximal Chr 11 deletion, however if so, it does not cover Egfr<wa2> nor Wnt3a<vt>. Heterozygotes: various phenotypic effects including white toes, head/belly spots and kinked/short tail. Breeding data indicate little or no prenatal loss and that mutant phenotype is not fully penetrant. Homozygotes: breeding data suggest little or no loss prior to birth, but that they die (probably early) post-natally.Order
STOCK Mut640/H Mut640 15Heterozygotes: small with pale ears, darker coat, white tip to tail. Breeding data suggest that 50% may die perinatally. About 70% of phenotyped heterozygotes at birth survive to weaning. Homozygotes: most, if not all, lost pre-implantation.Order
STOCK Mut778/H Mut778 Mut778/+ can be identified by their dark genetalia, they are also small and some have a slightly domed head and darkish coat. Heterozygotes are smaller at birth and weaning: of those that survived long enough to assign a genotype, Mut778/+ were about 25% smaller at birth and about 40% smaller than wild-type sibs at weaning. Opening data indicate that homozygotes are lost pre-implantation and that some heterozygous embryos are exencephalic. Viability of Mut778/+ is reduced (estimated to be circa 30%) between birth and weaning.Order
MUT791 Chy8 milky abdomen, puffy feet /tail. From crosses of 3H1 females to heterozygous males, under 40% of the offspring exhibited the milky abdomen phenotype, of these, over 70% survived through to weaning.Order
STOCK Mut810/H Mut810 Heterozygotes: head bobbing/waltzing. Some are small at weaning. Opening data show that heterozygotes are fully viable embryonically. Breeding data on a 3H1 background indicate a circa 30% shortfall of affected individuals by weaning, either due to lethality or the mutation not being fully penetrant. Penetrance on outcrossing to C57BL/6J is much reduced. Opening data indicate that homozygotes are lost by early post implantation. Mut810 showed no evidence of linkage with Edar<dl> and is therefore not an allele of Cdh23<v>.Order
STOCK Mut873/H Mut873 Small at birth and small with domed head by weaning. Opening data provide good evidence that homozygotes die pre-implantation. Some heterozygotes probably lost prior to birth; viability from birth to weaning is approx 50%. At weaning Mut873/+ are circa 40% lighter than wild-type sibs. Linkage data: weak evidence of linkage to distal Chr1. No obvious visible cytogenetic abnormality. Not deaf.Order
MUT878 Chy9 Small at birth with milky abdomen. From crosses of heterozygous males to 3H1 females, under 25% of the offspring exhibited the milky abdomen phenotype - approx 70% of these survived through to weaning age. Affected offspring are approx 15% lighter than normal sibs, and 25% lighter by weaning.Order
STOCK Mut921/H Mut921 Key feature of heterozygotes is a short broad head, wide between eyes, shortened nasal passage with occasional indication of cleft. White feet and belly spots also seen. Small at birth and weaning (approx 30% lighter than wild-type sibs). Recovery at birth reduced due to some prenatal loss of foetuses with more extreme head abnormality. Viability from birth to weaning is circa 60%. Homozygotes are probably lethal pre-implantation.Order From EMMA
STOCK Mut955/H Mut955 Mut955/+ exhibit head bobbing phenotype, may have darker coats and be slightly reduced in size. On 3H1 background, penetrance of the mutation and viability of heterozygotes to weaning is good. On outcrossing to C57BL/6J, penetrance of Mut955 is greatly reduced. Homozygotes are lost by early post implantation. Mut955/+ animals are not deaf. Cytogenetics: no obvious abnormality has been detected.Order
STOCK Mut960/H Mut960 Mut960/+ exhibit headbobbing and/or waltzing phenotype by weaning. In outcrosses on a predominantly (C3H/HeH x 101/H) F1 background there was an approx 30% shortfall in affected offspring due to reduced viability and/or penetrance of the mutation. Much reduced penetrance of mutation on outcrossing to C57BL/6J. Homozygotes: die by early post implantation. Cytogenetics: no obvious chromosomal abnormality.Order
STOCK Bloc1s5<mu>/H Bloc1s5<mu> 13Muted. Lighter coat.Order
MUTN212 Circling, limb grasp & trunk curl.Order
STOCK Mutn673/H Small, deaf.Order
MUTN777 Right eye missing, very active, circling.Order
MUTN873 Small, deep set eyes, short face, nose bends to left, upper teeth bent back, nose crooked, hunched, high gait & pelvic elevation, no abdominal tone, slow heart rate.Order
C3H;C-Muts1/14/H Small eye mutationOrder From EMMA
C57BL/6NTac-Mxra7tm1
a(EUCOMM)Wtsi/H 		Mxra7<tm1a(EUCOMM)Wt
si> 		11Potential EUMODIC data in the Europhenome database.Order From EMMA
B6Dnk;B6N-Rnf7<tm1a(
EUCOMM)Wtsi>/H 		Rnf7<tm1a(EUCOMM)Wts
i> 		9Potential EUMODIC data in the Europhenome database. Order
B6NDen;B6N-Mybpc3<tm
1a(EUCOMM)Hmgu>/H 		Mybpc3<tm1a(EUCOMM)H
mgu> 		2Potential EUMODIC data in the Europhenome database. Order From EMMA
B6;129-Myl2<tm1(cre)
Krc>/H 		Myl2<tm1(cre)Krc> 5Order
STOCK Myo7a<sh1-9J>/
H 		Myo7a<sh1-9J> 7Homozygotes exhibit circling behaviour. Stock sensitive to disturbance. Heterozygote breeders may chew litters.Order
C3H101HF1 x STOCK d-
100H Bmp5<se-m>/+ +/H 		d-100H 9Homozygotes are lethal. Compound heterozygotes Myo5a<d-100H>/Myo5a<d-l> are opisthotonic (lethal by weaning). This mutation also affects Bmp5 (compound heterozygotes with Bmp5<se> have short ears). Thus this mutation is probably a deletion.Order
d-100H 9
Myo5a<d-50H> Bmp5<se> 9Homozygotes are opisthotonic. Compound heterozygotes with dilute look like dilute homozygotes.Order
Myo5a<d-50H> 9
STOCK Myo5a<d-51H> +
/+ Bmp5<se>/H 		Bmp5<se> 9Homozygotes are opisthotonic. Compound heterozygotes with dilute look like dilute homozygotes.Order
Myo5a<d-51H> 9
STOCK Myo5a<d-53H> +
/+ Bmp5<se>/H 		Bmp5<se> 9Homozygotes are opisthotonic. Compound heterozygotes with dilute look like dilute homozygotes.Order
Myo5a<d-53H> 9
STOCK Myo5a<d-82H> +
/+ Bmp5<se>/H 		Bmp5<se> 9Homozygotes are opisthotonic (lethal by weaning).Order
Myo5a<d-82H> 9
STOCK Myo5a<d-83H> +
/+ Bmp5<se>/H 		Bmp5<se> 9Homozygotes are opisthotonic (lethal by weaning).Order
Myo5a<d-83H> 9
STOCK Myo5a<d-84H> +
/+ Bmp5<se>/H 		Bmp5<se> 9Homozygotes are opisthotonic (lethal by weaning).Order
Myo5a<d-84H> 9
STOCK Myo5a<d-85H> +
/Myo5a<d> Bmp5<se>/H 		Bmp5<se> 9Homozygotes are opisthotonic (lethal by weaning).Order
Myo5a<d> 9
Myo5a<d-85H> 9
C3H101HF1 x STOCK My
o5a<d-86H> +/Myo5a<d> Bmp5<se>/H 		Bmp5<se> 9Homozygotes are opisthotonic (lethal by weaning.Order
Myo5a<d> 9
Myo5a<d-86H> 9
C3H101H-Myo5a<d-88H>
/H 		Myo5a<d> 9Homozygotes are opisthotonic (lethal by weaning).Order
Bmp5<se> 9
C3H101H-Myo5a<d-89H>
/H 		Myo5a<d> 9Matings to produce homozygotes not performed, nor matings to produce compound heterozygotes with a known Myo5a dilute opisthotonia allele. therefore not known whether this allele will cause opisthotonia.Order
Bmp5<se> 9
Myo5a<d-89H> 9
STOCK Myo5a<d-90H>/H Myo5a<d> 9Matings to produce homozygotes not performed. Myo5a<d-90H>/Myo5a<d-l> are opisthotonic (lethal by weaning).Order
Bmp5<se> 9
Myo5a<d-90H> 9
C3H101HF1 x STOCK My
o5a<d-91H> +/Myo5a<d> Bmp5<se>/H 		Bmp5<se> 9Matings to produce homozygotes not performed. Myo5a<d-90H>/Myo5a<d-l> are opisthotonic (lethal by weaning).Order
Myo5a<d> 9
C3H101HF1 x STOCK My
o5a<d-92H>/H 		Bmp5<se> 9Matings to produce homozygotes not performed. Compound heterozygotes Myo5a<d-92H>/Myo5a<d-l> are opisthotonic (lethal by weaning).Order
Myo5a<d> 9
STOCK Myo5a<d-93H>/H Myo5a<d> 9Compound heterozygotes Myo5a<d-93H>/Myo5a<d-l> are opisthotonic (lethal by weaning).Order
Bmp5<se> 9
Myo5a<d-93H> 9
C3H101HF1 x STOCK My
o5a<d-97H> +/Myo5a<d> Bmp5<se>/H 		Myo5a<d> 9Homozygotes are opisthotonic (lethal by weaning)as are compound heterozygotes with Myo5a<d-86H>.Order
Bmp5<se> 9
Myo5a<d-97H> 9
STOCK Myo5a<d<105H>/
H 		Myo5a<d-105H> 9Myo5a<d-105H>/Myo5a<d> looks like Myo5a<d>/Myo5a<d>. Myo5a<d-105H>/Myo5a<d-105H> is viable.Order
STOCK Myo5a<d<52H>/H Myo5a<d-52H> 9Myo5a<d-52H>/Myo5a<d> looks like Myo5a<d>/Myo5a<d>. Myo5a<d-52H>/Myo5a<d-52H> is viable.Order
C3H101HF1 x STOCK My
o5a<d-58H>Bmp5<se>/H 		Bmp5<se> 9Homozygous lethal. Myo5a<d-58H>/Myo5a<d-l> are opisthotonic (lethal by weaning). This mutation also affects Bmp5 (compound heterozygotes with Bmp5<se> have short ears). Thus this mutation is probably a deletion encompassing both Myo5a and Bmp5.Order
d-58H 9
d-58H 9
STOCK Myo5a<d<61H>/H Myo5a<d-61H> 9Homozygotes are viable.Order
STOCK Myo5a<d<78H>/H Myo5a<d-78H> 9Homozygotes are viable. Myo5a<d-78H>/Myo5a<d> look like Myo5a<d>/Myo5a<d>.Order
STOCK Myo5a<d-80H> +
/+ Bmp5<se>/H 		Bmp5<se> 9Order
Myo5a<d-80H> 9
STOCK Myo7a<26SB>/Ni
hrH 		Myo7a<26SB> 7Shaker 1 allele. Homozygotes exhibit almost constant circling behaviour. Heterozygotes and wildtypes are indistinguishable from each other. Homozygotes show no preyer reflex. These Myo7a mutants do have severe hearing and vestibular abnormalities. While their retinas do not show any anatomical degeneration, there have been reports of retinal abnormalities. Order From EMMA
STOCK Myo7a<3336SB>/
NihrH 		Myo7a<3336SB> 7Shaker.Order From EMMA
STOCK Myo7a<4494SB>/
NihrH 		Myo7a<4494SB> 7shakerOrder From EMMA
STOCK Myo7a<4626SB>/
NihrH 		Myo7a<4626SB> 7Shaker. Deafness, headshaking, circlingOrder From EMMA
Myo7a<sh1-6J> Myo7a<sh1-6J> 7Shaker.Order
STOCK Myo7a<sh1-6J>/
WtsiH 		Myo7a<sh1-6J> 7Homozygotes show head bobbing, circling behaviour and deafness.(hyperactivity). Order From EMMA
Myo7a<sh1-8165SB> shaker. Homozygotes exhibit almost constant circling behaviour. Heterozygotes and wildtypes are indistinguishable from each other. Homozygotes show no preyer reflex. Homozygote females will not rear littersOrder
STOCK Myo7a<816SB>/N
ihrH 		Myo7a<816SB> 7Homozygotes exhibit almost constant circling behaviour. Heterozygotes and wild types are not distinguishable from each other. Homozygotes show no preyer reflexOrder From EMMA
Myo7a<sh1> Myo7a<sh1> 7Shaker.Order
TgN(DSPM36)1668OxAna
t 		Order
C3H101H-Klf1<Nan>/H Klf1<Nan> 8Neonatal anaemia.Order
C3.C-Nano/H Nano XHeterozygotes have small narrow faces. With aging, they develop patches of white hairs on their back. Hemizygous males are presumed to die in utero.Order From EMMA
Pde6b<rd1> 5
Tyr<c> 7
Tyrp1<b> 4
B6.129P2-Nat2<tm1Esi
m>/H 		Nat2<tm1Esim> 8None.Order From EMMA
B6.129S6-Scn3a<tm1Jw
o>/H 		Scn3a 2No obvious defects.Order From EMMA
B6;129-Scn10a<tm3(cr
e/ERT2)Jnw>/H 		Scn10a<tm3(cre/ERT2)
Jnw> 		9None observed (heterozygous Nav1.8-CreERT2 can express enough Cre to delete the floxed fragement, but it does not affect the expression of Nav1.8 in Nav1.8 positive neurons in DRG).Order From EMMA
B6.129P2-Scn10a<tm1J
nw>/Jnw 		Scn10a<tm1Jnw> 9Defects in mechanical and inflammatory pain tests. Order From EMMA
B6.129-Scn10a<tm2(cr
e)Jnw>/H 		Scn10a<tm2(cre)Jnw> 9No phenotype in heterozygotes. Some pain deficits in homozygotes.Order From EMMA
B6;129-Nek6<tm1Dgen>
/H 		Nek6<tm1Dgen> 2No visible phenotype.Order From EMMA
Nephertiti No visible phenotype. Mice develop nephrotic range proteinuria at a young age and has abnormal liver histology, similar to Lafora body disease. Order From EMMA
Nespas<tm1Jop> Nespas<tm1Jop> 2Heterozygotes with paternal inheritance of deletion die within 1-2 days of birth. Heterozygotes with maternal inheritance of deletion appear normal.Order
B6Dnk;B6N-Nipsnap1<t
m1a(EUCOMM)Wtsi>/H 		Nipsnap1<tm1a(EUCOMM
)Wtsi> 		11Potential EUMODIC data in the Europhenome database.Order From EMMA
B6;129-Nkx2-5<tm1(cr
e)Rjs>/H 		Nkx2-5<tm1(cre)Rjs> 17Order
Nmnat1<tm1Cole> NoneOrder
Nmnat1<tm2Cole> Nmnat1 4None observed. Order
C3.Cg-Crygb<Nop>/H ?
? (Check) 		Crygb<Nop> 1Nuclear opacity. Dominant cataractOrder
STOCK Mut1231/H Mut1231 11Heterozygotes have curly whiskers and progressive hair loss commencing 8-12 days after birth by which time the skin is loose and wrinkled. By weaning most of the fur has gone from heterozygotes, by adulthood they are bald. Opening data are inconsistent, but suggest that some, if not all, homozygotes are lost pre-implantation. Openings from 3H1 females crossed to heterozygous males indicate little or no loss of Mut1231/+ prior to birth. Reciprocal openings suggest that heterozygous females have impaired ability to carry large litters to term. Viability of heterozygotes to weaning is good. Penetrance of the mutation on a 3H1 background and on outcrossing to Mus castaneus is also good. Mapping data (which position Mut1231 on Chr11) gave the following linkage: Cross 1: Mut1231 - 14.55 cM +/- 3.36 cM - Re. Cross 2: D11Mit1 - 30 cM +/- 6.48 cM - Mut1231 - 22 cM +/- 5.86 cM - D11Mit329. Intercrosses of mice heterozygous for both Mut1231 and Foxn1<nu> failed to produce any phenotypically wild-type pups out of 213 offspring scored indicating that Mut1231 and Foxn1<nu> are either allelic, or closely linked. Unlike Foxn1<nu>/Foxn1<nu>, Mut1231/+ mice are not athymic at weaning.Order From EMMA
C3H;102-Cryge<No3>/H Cryge<No3> 1Nuclear opacity 3. Dominant cataract.Order From EMMA
Nodal<tm3Rob> Nodal<tm3Rob> 10Heterozygotes show no phenotype, homozygous results in disrupted L/R patterning.Order
NOD Age related onset of diabetes.Order
NPA31-B4 Offspring inheriting the targeted construct paternally do not feed, are hypoactive and die within a few hours.Order
B6NTac;B6N-Npc1<tm1a
(EUCOMM)Hmgu>/H 		Npc1<tm1a(EUCOMM)Hmg
u> 		18Potential EUMODIC data in the Europhenome database.Order From EMMA
C3.Cg-Npp/H Npp 5Nuclear-posterior polar opacity. Dominant cataractOrder
B6;129P2-Npy6r<tm1Dg
en>/H 		Npy6r<tm1Dgen> 18No visible phenotype.Order From EMMA
B6;129P2-Nr1d2<tm1Dg
en>/H 		Nr1d2<tm1Dgen> 14No visible phenotype.Order From EMMA
B6.129P2-Nr1d2<tm1Dg
en>/H 		Nr1d2<tm1Dgen> 14No visible phenotype.Order From EMMA
C3;102-Casr<Nuf>/H Casr<Nuf> 16Small flecks in lens nucleus, difficult to see in heterozygote, clearer in homozygotes. The Nuf mice also exhibit ectopic calcification, hypocalcemia, hyperphosphatemia, and innapropriately reduced levels of plasma parathyroid hormone. Order From EMMA
B6Dnk;B6N-Nup88<tm1a
(EUCOMM)Wtsi>/H 		Nup88<tm1a(EUCOMM)Wt
si> 		11Potential EUMODIC data in the Europhenome database.Order From EMMA
NVPD Order
Och, Re<wc> Krt27<Re-wc> 11Och, ochre. Re<wc>, wavy coat.Order
Och 4
STOCK Gnas<Oedsml>/H Gnas<Oedsml> 2When inherited through the female, the offspring are oedematous. When inherited through the male, the offspring show postnatal growth retardation.Order
C3H.Cg-Crygs<Opj>/H Crygs<Opj> 16Opaque fibre cell junctions. Dominant cataract.Order From EMMA
STOCK Pax2<Opdc>/H Pax2<Opdc> 19Optic disc coloboma. Mutants have retinal vascular abnormalities and optic discs of unusual size. Order From EMMA
B6Dnk;B6N-Orc5<tm1a(
EUCOMM)Wtsi>/H 		Orc5<tm1a(EUCOMM)Wts
i> 		5Potential EUMODIC data in the Europhenome database.Order From EMMA
STOCK Ostes/H Muscular dystrophy, small size, muscle wasting.Order
STOCK Ostes/H Ostes Muscular dystrophy, small size and muscle wasting.Order From EMMA
C.Cg-Ostes/H Ostes Small with muscle tremor.Order
P-Rex1 CE3/B6 Functional neutrophil deficiencyOrder
B6.129-S100A10<tm1Jn
w>/H 		S100a10<tm1Jnw> 3None. Order From EMMA
B6;129P2-P2rx6<tm1Dg
en>/H 		P2rx6<tm1Dgen> 16No visible phenotype.Order From EMMA
B6;129-P2ry12<tm1Dge
n>/H 		P2ry12<tm1Dgen> 3NoneOrder From EMMA
129-Ncf1<tm1Hbd>/H Ncf1<tm1Hbd> 5Impaired innate immunity. Order From EMMA
STOCK In(7Oca2;7Sox6
)100H/H 		Oca2<p-d> 7Order
In(7Oca2;7Sox6)100H 7
STOCK Oca2<p-55H> +/
+ Tyr<c-ch>/H 		Tyr<c-ch> 7Oca2<p-55H>/Oca2<p> looks like Oca2<p>/Oca2<p>. Oca2<p-55H>/Oca2<p-55H> is a pre-natal lethal.Order
Oca2<p-55H> 7
STOCK Oca2<p-61H>/H Oca2<p-61H> 7Oca2<p-61H>/Oca2<p> is slightly darker than Oca2<p>/Oca2<p>. Oca2<p-61H>/Oca2<p-61H> is viable.Order
STOCK Oca2<p-65H>/H Oca2<p-65H> 7Coat and eyes of Oca2<p-65H>/Oca2<p> darker than Oca2<p>/Oca2<p>. Coat and eyes of Oca2<p<65>/Oca2<p65> only slightly lighter than wild-type.Order
C3H101HF1 x STOCK Oc
a2<p-66H>/H 		Oca2<p-66H> 7Oca2<p-66H>/Oca2<p> coat looks darker than Oca2<p>/Oca2<p>. Oca2<p-66H>/Oca2<p-66H> ruby eyes, light coloured ears and tail, sandy brown tips to fur, dark under fur.Order
Oca2 7
STOCK Oca2<p-78H>/H Oca2<p-78H> 7p<78>/p looks like b/b. Coat and eyes of p<78>/p<78> only slightly lighter than wild type.Order
STOCK Oca2<p-79H>/H Order
STOCK Oca2<p-80H>/H Oca2<p-80H> 7Oca2<p-80H>/Oca2<p> and Oca2<p-80H>/Oca2<p-80H> look like Oca2<p>/Oca2<p>.Order
C3H101H-Oca2<p-81H>/
Oca2<p-d>/H 		Oca2<p-81H> 7Phenotype of p<81H>/p is similar to p/p, homozygotes die pre-natallyOrder
Oca2<p-d> 7
STOCK Oca2<p-82H>/Oc
a2<p-d>/H 		Oca2<p-82H> 7phenotype of p<82H>/p is similar to p/p, homozygotes die pre-natallyOrder
Oca2<p-d> 7
STOCK Oca2<p-83H>/H Oca2<p-83H> 7Oca2<p-83H>/Oca2p coat looks slightly darker than Oca2<p>/Oca2<p>.Order
STOCK Oca2<p-84H>/H Oca2<p-84H> 7Phenotype of homozygotes is similare to p/p.Order
C3H101HF1 x STOCK Oc
a2<p-85H>/H 		Oca2<p-85H> 7Oca2<p-85H>/Oca2<p> and Oca2<p-85H>/Oca2<p-85H> look like Oca2<p>/Oca2<p>.Order
C3H101HF1 x STOCK Oc
a2<p-86H>/H 		Oca2<p-86H> 7Phenotype similar to p/p.Order
C3H101HF1 x STOCK Oc
a2<p-87H>T(7;11)64H/H 		Oca2<p-87H> 7Order
Oca2<p-d> 7
STOCK Oca2<p-88H>/H Oca2<p-88H> 7Phenotype of homozygotes is similar to p/p.Order
STOCK Oca2<p-91H>/H Oca2<p-91H> 7Oca2<p-91H>/Oca2<p> looks like Oca2<p>/Oca2<p>Order
STOCK Oca2<p-92H>/H Oca2<p-92H> 7Oca2<p-92H>/Oca2<p> looks like Oca2<p>/Oca2<p>. Oca2<p-92H>/Oca2<p-92H> is viable.Order
C3H101HF1 x STOCK Oc
a2<p-93H>/H 		Oca2<p-d> 7Oca2<p-93H>/Oca2<p> looks like Oca2<p>/Oca2<p>. Oca2<p-93H>/Oca2<p-93H> is prenatal lethal.Order
Oca2<p-93H> 7
STOCK Oca2<p-95H>/H Oca2<p-95H> 7Oca2<p-95H>/Oca2<p> looks like Oca2<p>/Oca2<p>. Oca2<p-95H>/Oca2<p-95H> is viable.Order
p<96H> Oca2<p-d> 7Oca2<p-96H>/Oca2<p-cp> has cleft palate. Oca2<p-96H>/Oca2<p-96H> is a prenatal lethal.Order
Oca2<p-96H> 7
STOCK Oca2<p-97H>/H Oca2<p-97H> 7Oca2<p-97H>/Oca2<p-97H> is viable.Order
STOCK Oca2<p-98H>/H Oca2<p-d> 7Oca2<p-98H>/Oca2<p> looks like Oca2<p>/Oca2<p> Oca2<p-98H>/Oca2<p-98H> is lethal.Order
Oca2<p-98H> 7
STOCK Oca2<p-99H> +/
Oca2<p-d> +/H 		Oca2<p-d> 7Oca2<p-99H>/Oca2<p-99H> is lethal.Order
Oca2<p-99H> 7
C3H101HF1 x STOCK Oc
a2<p-bs>/Oca2<p-d>/H 		Oca2<p-bs> 7p-black-eyed sterileOrder
Oca2<p-d> 7
C3H101HF1 x STOCK Oc
a2<p-cp>/Oca2<p-bs>/H 		Oca2<p-cp> 7Coat colour same as p/p. p-black-eyed sterile, originally p<24>H,p<bs>/p<bs> viable but smallish, have slightly jerky behaviour, usually sterile & darker in colour than p<bs>/p<cp>, p<cp>/p<cp> usually die around birth from cleft palate, few have lived.Order
Oca2<p-bs> 7
p<d>, p<25H> Oca2<p-d> 7p<d>/p<d> eyes light at birth, dark at weaning. Coat similar to b/b but less "orange".Order
Oca2<p-25H> 7
p<d>, p<6H> Oca2<p-d> 7p<d>/p<d> eyes light at birth, dark at weaning. Coat similar to b/b but less "orange"Order
Oca2<p-6H> 7
STOCK Oca2<p-dn>/H Oca2<p-dn> 7Eyes pink at birth but darken by weaning. Coat slightly darker than p/p.Order
C3H101HF1 x STOCK Oc
a2<p-dn>/H 		Oca2<p-dn> 7Order
C3H101HF1 x STOCK Oc
a2<p-un>/H 		Oca2<p-un> 7pink-eyed unstableOrder
Myo5a<d> 9
C3H101H-Oca2<p-x>/H Oca2<p-x> 7Eyes dark at birth and weaning, coat only slightly lighter than wild typeOrder
B6Dnk;B6N-Pa2g4<tm1a
(EUCOMM)Wtsi>/H 		Pa2g4<tm1a(EUCOMM)Wt
si> 		10Potential EUMODIC data in the Europhenome database.Order From EMMA
C3H/He-Paf/H Paf XPatchy fur.Order
B6;129P2-Pak2<tm1Dge
n>/H 		Pak2<tm1Dgen> 16NoneOrder From EMMA
C57BL/6NTac-Parl<tm1
a(EUCOMM)Hmgu>/H 		Parl<tm1a(EUCOMM)Hmg
u> 		16Potential EUMODIC data in the Europhenome database.Order From EMMA
PARX NormalOrder From EMMA
C3H101H-Pax3<Sp-1H>/
H 		Pax3<Sp-1H> 1Splotch.Order
C3H101H-Pax3<Sp-2H>/
H 		Pax3<Sp-2H> 1Splotch.Order From EMMA
C3H101H-Pax3<Sp-4H>/
H 		Pax3<Sp-4H> 1Order
C3H101H-Pax3<Sp-5H>/
H 		Pax3<Sp-5H> 1Splotch.Order
C3H101H-Del(1)3H/H Del(1)3H 1splotch-retarded, spottingOrder From EMMA
Pax3<Sp>, Tyrp1<b-cH
> 		Pax3<Sp> 1Splotch.Order
Tyrp1<b-cH> 4
Tyrp1<b> 4
C3.D2-Pax6<Coop>/H Pax6<Coop> 2Heterozygotes have corneal opacity with iris anomaly and small eyesOrder
C3;C-Pax6<Leca4>/H Pax6<Leca4> 2Mutants have small eyes, but not always corneal opacity (corneal opacity affects most other Pax6 mutants). Often have anterior cataract.Order From EMMA
Pax6<Sey-Neu> Pax6<Sey-Neu> 2Small eyeOrder
B6NDen;B6N-Pbx3<tm1a
(EUCOMM)Wtsi>/H 		Pbx3<tm1a(EUCOMM)Wts
i> 		2Potential EUMODIC data in the Europhenome database.Order From EMMA
PC a 2Order
Oca2<p> 7
Tyr<c-ch> 7
PCE/JP a<t> 2Order
Sox18<Ra> 2
Edn3<ls> 2
Myo5a<d> 9
Egfr<wa2> 11
Wnt3a<vt> 11
C3H101H-Slc40a1<Pcm>
/H 		Slc40a1<Pcm> 1Heterozygotes have red ears and feet; however, the phenotype is variable over time. Haematocrit scores of up to 75% have been seen. Linkage with albino was not seen, indicating that Hbb locus was not involved. Later shown to be 58 bp deletion in the promoter region of Slc40a1.Order From EMMA
B6;129P2-Pde2a<tm1Dg
en>/H 		Pde2a<tm1Dgen> 7No visible phenotype.Order From EMMA
B6;129P2-Pde3a<tm1Dg
en>/H 		Pde3a<tm1Dgen> 6No visible phenotype.Order From EMMA
B6;129P2-Pde4b<tm1Dg
en>/H 		Pde4b<tm1Dgen> 4No visible phenotype.Order From EMMA
B6;129P2-Pde4d<tm1Dg
en>/H 		Pde4d<tm1Dgen> 13No visible phenotype.Order From EMMA
B6;129P2-Pde8a<tm1Dg
en>/H 		Pde8a<tm1Dgen> 7No visible phenotype.Order From EMMA
CBA/H-Pdss2<kd>/H Pdss2<kd> 10Kidney disease. Homozygotes develop nephrosis recognizable at about 10 weeks of age by drinking, loss of weight, anaemia, and death usually at 5 to 7 months. Order
C3H;B6-Galnt3<tcal>/
H 		Galnt3<tcal> 2Hyperphosphataemia and ectopic calcification in homozygotes. The homozygote males are also infertile.Order
PED-JP/16 Order
C3H101H-Pedc/H Pedc Pale ears, dark coat. Pre-implantation loss of homozygotes. Order
PEDM/105 Elevated plasma phosphate.Order
PEDM/14 Hyperglycaemia. Elevated plasma glucose at 16 and 24 weeks of age. No detection of glucose in the urine.Order From EMMA
C3H;B6-Pedm15/H High anxiety, tremors, small at weaning.Order From EMMA
C3H;B6-PEDM25/H This strain demonstrates late onset (>6 months of age) tremors and some individuals have a high nose-poking response in a behavioural test.Order From EMMA
C3H;B6-PEDM29/H Highly active and demonstrates a high degree of anxiety Order From EMMA
PEDM/32 AlbuminuriaOrder
PEDM/35 Hyperglycaemia and glycosuria.Order From EMMA
C3H;B6-PEDM36/H Limb grasping, walks backwards, inactive.Order From EMMA
C3H;B6-PEDM41/H Deformed digits shortened limbs.Order From EMMA
C3H;B6-PEDM42/H Homozygotes have a belted white band of hair around the mouse middle. Their appearance is similar to that of the known mutation on Chromosome 15, Adamts20<bt> (Belted).Order From EMMA
PEDM52 Presumed homozygotes have spina bifida.Order
PEDM/83 Short/long faces and small mis-shapen eye sockets.Order
PEDV/119 Order
PEDV/128 Order
PEDV/146 Dark skin in marble like patterns, slightly darker fur.Order
PEDV/156 Headbob & head tilt.Order
Pge<1H> Order
Pge<2H> Order
Pge<3H> Order
B.Cg-Pgk1<a>/WsH Order From EMMA
Pgm1<n1H> Pgm1<m1H> 5No enzyme activity detected by staining of electrophoretic plate. Homozygotes viable, fertile and have no obvious phenotype.Order
Pgm1<n2H> Pgm1<m2H> 5No enzyme activity detected by staining of electrophoretic plate. Homozygotes viable, fertile and have no obvious phenotype.Order
Pgm1<n3H> Pgm1<m3H> 5No enzyme activity detected by staining of electrophoretic plate. Homozygotes viable, fertile and have no obvious phenotype.Order
Pgm1<n4H> Pgm1<m4H> 5No enzyme activity detected by staining of electrophoretic plate. Homozygotes viable, fertile and have no obvious phenotype.Order
C3H101H-Pgm2<am>/H Order
STOCK Ph/H Ph 5White 'belt'. Heterozygotes have a sharply defined white spotting in the belt region. The skull is a little wider and shorter than normal and has a large interfrontal bone. Homozygotes die in utero from about 10 days of gestation onward. See GVSLM 3 pg 613.Order
C3H101HF1 x STOCK Ph
<3H>/H 		Ph<3H> 5patchOrder
STOCK Gy/H Gy XGyro.Order
Atp7a<Mo-blo> X
Eda<Ta> X
STOCK Eda<Ta> Phex<H
yp>/H 		Phex<Hyp> XhypophosphatemiaOrder
Eda<Ta> X
C3H101H-Pkm2<r>/H Pkm<a> 9Order
Pkm<b> 9
Pkm<r> 9
PKDBac Line2 Hets appear normal. Homs are small and develop hind-limb dragging at 4-6 weeks old Order
C57BL/6JApb-Ikzf1<Pl
stc>/Apb 		Ikzf1<plstc> 11Embryonic lethal E15.5-17.5. Anaemia. Failure of normal erythroblast growth & differntiation in feotal liver. Expansion of myeloid cells.Order From EMMA
C3H;C-Play50/H Play50 Identified in circadian rhythm screen. Reduced bouts of wheel- running activityOrder From EMMA
C3;C-Play63/H Reduced bouts of wheel- running activity.Order From EMMA
C3H.Cg-Play1/H These mice have a higher than normal degree of daytime activity in a 12:12 light:dark cycle.Order From EMMA
C3H;C-Play16/H No entrainment response to light pulses given at CT16.Order From EMMA
C3C-Play19/H Identified in circadian rhythm screen. Potentially no entrainment response to light pulses given at CT16Order From EMMA
C3H.C-Play22/H Play22 Mice carrying this mutation show a low endurance of wheel running activity. Wheel running activity is about 10% of control animals.Order From EMMA
C3H;C-Play31/H Identified in a circadian rhythm screen. Wheel turning activity is dramatically reduced in a 12:12 light:dark cycle.Order From EMMA
C3H;C-Play32/H Identified in a circadian rhythm screen. These mice have reduced bouts of wheel running activity in a 12:12 light:dark cycle. Order From EMMA
C3H;C-Play36/H Play36 Identified by circadian rhythm screen. Mutant mice demonstrate an increased phase shift after light pulse.Order From EMMA
C3H;C-Play40/H Identified in circadian rhythm screen. Mutants have potentially no entrainment response to light.Order From EMMA
C3H;C-Play41/H Play41 Identified in circadian rhythm screen. Mutant mice demonstrate a long circadian period (24-24.5hr), and reduced activity.Order From EMMA
C3H;C-Play42/H Identified in a circadian rhythm screen. These mice have two sets of activity onsets when first exposed to constant darkness conditions.Order From EMMA
C3H;C-Play44/H Identified in circadian rhythm screen. Potentially shows a large entrainment response to light and phase advancement in a 12:12 light:dark cycle.Order From EMMA
C3H;C-Play46/H Play46 Poor entrainment to light in 12:12 light dark: cycle.Order From EMMA
C3H;C-Play47/H Identified in circadian rhythm screen. These mice free run in a 12:12 light:dark cycle.Order From EMMA
C3H;C-Play57/H Play57 Identified in circadian rhythm screen. Mutant mice demonstrate a shorter cicadian wild type.Order From EMMA
C3H;C-Play65/H Changed period length after light pulse at CT16.Order From EMMA
C3H;C-Play72/H Reduced bouts of wheel running activity.Order From EMMA
C3H;C-Play78/H Potentially no entrainment response to light.Order From EMMA
C3H;C-Play79/H Poor entrainment response to light.Order From EMMA
C3H;C-Play81/H Long circadian period & poor entrainment responseOrder From EMMA
C3H;C-Play82/H This mutation was identified in a circadian rhythm screen. It shows reduced bouts of wheel-running activity.Order From EMMA
Plcg2<tm>-383/Bcl2-3
6Tg 		Plcg2 8B cell dysfunction. Homozygotes are infertile.Order From EMMA
ple ples Pale.Order
ples UN
C3H101H-Plp1<jp-rsh>
/H 		Plp1<jp-rsh> XShivering/shaking of hind quarters.Order
C3H;C-Gena300/H Tyr<c> 7Late onset deafness.Order From EMMA
Tyrp1<b> 4
Pde6b<rd1> 5
B6;129P2-Prep<tm1Dge
n>/H 		Prep<tm1Dgen> 10NoneOrder From EMMA
129P2/OlaHsd-Prnp/Pr
nd<tm1Dwm>/H 		Prnp/Prnd<tm1Dwm> 2No phenotype in female mice. Male homozygotes are sterile.Order
Prnp<a(108L_189V)>
(DD) 		No phenotypeOrder From EMMA
Pro-Cre None.Order From EMMA
C3;C-Grn<C227S>/H Grn 11No phenotype data recorded.Order
C3;C-Grn<I330F>/H Grn 11No phenotype data recorded.Order
C3;B6-Grn<Q47H>/H Grn 11No phenotype data recorded.Order
PrP Chicken-repeats Prnp<tm1Cwe> 2The octameric repeat region of the mouse prion protein was replaced with the hexameric repeat region from the domestic chicken. The mice express mouse PrP at wild-type levels with correct membrane location and orientation but have an altered metal binding region. The mice have been generated to get a better understanding of prion diseases such as CJD in humans.Order From EMMA
STOCK Tg(Prnp-SMN)92
Ahmb/H 		Tg(Prnp-SMN)92Ahmb These mice are aphenotypicOrder From EMMA
STOCK a<e>/a<e> Ps +
+/ + Tyrp1<b>Dock7<m>/H 		Ps 4Syndactyly, extra digit, webbing of soft tissue on feet. Homozygotes die at or before birth. Can be seen in utero at 13 dpc by lack of division of the footplates into digits and a wavy opical ectodermal ridge. Oedema also at 14 dpc.Order
Tyrp1<b> 4
a<e> 2
Dock7<m> 4
B6.129P2-Psip1<Gt(be
tageo)1Hgs>/H 		Psip1<Gt(betageo)1Hg
s> 		4Perinatal lethal, homozygotes have homeotic transformations and abnormal ribcage.Order From EMMA
PT Tyr<c-ch> 7Order
Ednrb<s> 14
Myo5a<d> 9
Tyrp1<b> 4
Bmp5<se> 9
Oca2<p> 7
PTP/H Myo5a<d> 9Order
Tyrp1<b> 4
Gpi1<a> 7
Tyr<c-ch> 7
Hbb<s> 7
Bmp5<se> 9
Ednrb<s> 14
a 2
Oca2<p> 7
B6;129-Ptprc<tm1Holm
>/H 		Ptprc<tm1Holm> 1Defective lymphocyte development, more severe in T lineage, severe combined immunodeficiency.Order From EMMA
C3H101HF1 x STOCK Wn
t7a<px>/H 		Wnt7a<px> 6Sterility. Skeletal abnormalities, mainly forelimb abnormalities. Postaxial hemimelia, recessive. The forelimbs are regularly affected. There may be absence of digits 5, 4, and 3, & reduction or absence of the ulna. There is always a large oval foramen in the scapula. The hindlimbs are usually normal, but digit 5 may be absent, and occasionally the fibula is reduced. Mice with severally affected limbs tend to have an extra pair of ribs and a slight reduction in number of presacral vertebrae. Both sexes are sterile and show anomalies of the Mullerian ducts, including a partly or wholly double vagina and uncoiled oviducts in the female, and peristent Mullerian ducts in the male. Order From EMMA
Qk<qk> Qk<qk-v> 17Homozygotes shake and tremble when walking. Males sterile. Order
Quaver Tremors.Order
STOCK Rb(4.6)2Bnr-Rb
(4.15)4Rma-Rb(6.15)1Ald-Adamts20<bt>/H 		Adamts20<bt> 15Order
STOCK Rb(4.6)2Bnr-Rb
(4.15)4Rma-Rb(6.15)1Ald-Tyrp1<B-lt>Adamts20<bt>/H 		Adamts20<bt> 15Order
Tyrp1<B-lt> 4
STOCK Rb(2.8)6Rma-Rb
(6.15)1Ald-Rb(9.19)163H/H 		Order
STOCK Rb(1.15)2Ct Rb
(2.18)6Rma Rb(6.13)3Rma Rb(11.16)2H/H 		Order
129P2/OlaHsd-Rab18<G
t(EUCE0233a03)Hmgu>/H 		Rab18<Gt(EUCE0233a03
)Hmgu> 		18Full description available from Europhenome. Order From EMMA
rag1<tm1ES> Rag1 2Order
C3;C-Rasgrf1<enu2H>/
H 		Rasgrf1<enu2H> 9Small.Order From EMMA
STOCK Rb(1.10)10Bnr Edar<dl> 10Order
STOCK ln-Rb(1.15)2Ct
/H 		Mlph<ln> 1Order
STOCK Rb(1.2)5H Edar
<dl> Kitl<Sl-con>/H 		Edar<dl> 10Order
Kitl<Sl-con> 10
Rb(1.2)5H 2
STOCK Rb(1.3)1Bnr Mlph<ln> 1Order
STOCK Rb(10.11)8Bnr Heterozygous females give low frequencies of aneuploid fetusesOrder
STOCK Rb(11.13)4Bnr Testis weight reduced in both homozygotes and heterozygotes.Order
STOCK Rb(11.16)2H Order
C3H101HF1 x STOCK Rb
(12.13)3Ct/H 		Rb(12.13)3Ct 13Order
STOCK Mgrn1<md> Rb(1
6.17)7Bnr T/Mgrn1<md> + +/H 		Rb(16.17)7Bnr 17Reduced testis weight in homozygotes.Order
STOCK Rb(16.19)1Bu/H Order
STOCK Rb(2.17)11Rma
T Itpr3<tf>/Rb(2.17)11Rma + Itpr3<tf>/H 		Itpr3<tf> 17Order
Rb(2.17)11Rma 17
tf 17
STOCK Rb(2.17)4H Order
STOCK Rb(2.18)6Rma Order
C3H101H-Rb(4.14)8H/H Order
STOCK Rb(4.15)4Rma A
damts20<bt-H>/H 		Adamts20<bt-H> 15Order
Rb(4.15)4Rma 15
C3H101H-Rb(4.16)10H Order
STOCK Rb(4.18)3H Order
STOCK Rb(4.6)2Bnr Tgfa<wa1> 6Order
Tyrp1<b> 4
Rb(4.6)2Bnr, Rb(9.14
)6Bnr 		Bmp5<se> 9Order
Tyrp1<b> 4
Tgfa<wa1> 6
Myo5a<d> 9
Ednrb<s> 14
STOCK Rb(5.15)3Bnr/H Order
STOCK Rb(5.19)1Wh Order
STOCK Rb(6.13)1H Order
C3H101HF1 x STOCK Rb
(6.13)3Rma/H 		Rb(6.13)3Rma 13Order
STOCK Rb(6.15)1Ald Order
C3H101HF1 x STOCK Rb
(8.12)5Bnr/H 		Rb(8.12)5Bnr 12Testis weights are reduced in both homozygotes and heterozygotes, and the sperm count for the former is significantly lower.Order
C3H101H x STOCK Rb(8
.19)1Ct/H 		Mc1r<e> 8Order
Rb(8.19)1Ct 19
STOCK Rb(9.14)6Bnr Myo5a<d> 9Testis weights are reduced in both homozygotes and heterozygotes and sperm count compared to control males was approximately halved in the former.Order
Ednrb<s> 14
Bmp5<se> 9
STOCK Rb(9.19)163H Hps6<ru> 19Order
C3H101H-Rb(X.12)7H A
tp7a<Mo-Blo>/H 		Atp7a<Mo-blo> XHeterozygous females are fertile but hemizygous males are sterileOrder
Rb(X.12)7H 12
STOCK Rb(X.2)2Ad Atp7a<Mo-blo> XOrder
Eda<Ta> X
STOCK Rb(X.9)6H Order
C3H;C-Rky/H Rky At 10 weeks of age, pups show a swim phenotype described as rocky, leaning and jerky. By 18 weeks of age mice develop a head-bobbing/circling cage phenotype. Order From EMMA
C3H;C-REC9/H Weak limb grasp, belly spot.Order From EMMA
C3H;B6-RECB13/H Single fetus observed with severe neural tube defect; possibly polygenic defectOrder From EMMA
C3H;B6-Tulp3<hhkr>/H Tulp3<hhkr> 6Homozygotes have spina bifida and oedema, and die at birth.Order
RECC/56 Tbx1 16Oedema, cardiac malformations (ventricular septal defect, common arterial trunk), palatal cleft, small or absent thymus, abnormal inner ear.Order From EMMA
B(BR)-Steap3<fred>/A
pb 		Steap3<fred> 1Abnormalities in red blood cell size and shape.Order From EMMA
Redeye Homozygous mutant mice exhibit a range of eye defects including pale retinas, vascular defects & white structures present in the eye.Order
B6.129-Reg2<tm1Lchr>
/H 		Reg2<tm1Lchr> 6Viable, normal breeding pattern, no obvious phenotype.Order From EMMA
STOCK Mitf<Rorp>/H Mitf<Rorp> 6Dilute coat/ear/tail colour. Heterozygotes have pigment dilution, while homozygotes lack coat pigment, but retain eye (iris) pigment and do not have small eyes.Order From EMMA
STOCK Rvm/H Rvm 14Retinal vascular abnormalities.Order From EMMA
STOCK Rwhs/H Rwhs 11Retinal white spots. In heterozygotes, white spots appear on the retina from one month of age. They do not seem to reduce vision. Order From EMMA
Pde6b<rd1> 5
Tyr<c> 7
Tyrp1<b> 4
B6;129P2-Rgs5<tm1Dge
n>/H 		Rgs5<tm1Dgen> 1No visible phenotype.Order From EMMA
B6NTac;B6N-Rhbdl3<tm
1a(EUCOMM)Wtsi>/H 		Rhbdl3<tm1a(EUCOMM)W
tsi> 		11Potential EUMODIC data in the Europhenome database.Order From EMMA
B6.129S-Rhbdd1<tm1.1
Mfm>/H 		Rhbdd1 1No overt phenotype Order
Ri Ringed.Order
Ricky X-linked hypophosphataemic rickets.Order
RIII/Dk ro 2Order
ro 2
RKS-XI Pkd1l1 11No overt phenotype. Believed to be a silent mutation of Pkd1l1. Order
STOCK Rn/H Rn 14Rn heterozygotes have white or partly pigmented hairs throughout coat. Homozygotes are lighter than heterozygotes and are viable and fertileOrder
STOCK Rn<fkl> Rn<fkl> 14freckledOrder
B6Dnk;B6N-Rnf7<tm1a(
EUCOMM)Wtsi>/H 		Rnf7<tm1a(EUCOMM)Wts
i> 		9Potential EUMODIC data in the Europhenome database. Order From EMMA
C3;C-Aff1<Rob>/H Aff1<Rob> 5Robotic and jerky gait. Heterozygotes exhibit small size, ataxia, adult-onset Purkinje cell loss, cataracts, reduced survival, and low fertility.Order From EMMA
Pde6b<rd1> 5
Tyr<c> 7
Tyrp1<b> 4
A<w> 2
ROHi Long term growth selected mouse line.Order
ROLi Long term growth selected lines.Order
C57BL/6NTac-Rpe65<tm
1a(EUCOMM)Hmgu>/H 		Rpe65<tm1a(EUCOMM)Hm
gu> 		3Potential EUMODIC data in the Europhenome database.Order From EMMA
B6NTac;B6N-Rprd1b<tm
1a(EUCOMM)Hmgu>/H 		Rprd1b<tm1a(EUCOMM)H
mgu> 		2Potential EUMODIC data in the Europhenome database.Order From EMMA
C3H101HF1 x STOCK rs
t/H 		rst rosette. This mutation affects hair growth pattern.Order
C3H101HF1 x STOCK Hp
s5<ru2> Oca2<p>/H 		Hps5<ru2> 7ruby-eyeOrder
Oca2<p> 7
C3H101H-Rw/H Rw 5Rw (rump-white) is homozygote lethal. Heterozygotes have white hindlegs and tails and white fur on the posterior part of the abdomen. Order From EMMA
C3H101H x STOCK Rw K
it<W-bd> +/+ + Kit<W-v>/H 		Kit<W-bd> 5No pigment in rump areaOrder
Kit<W-v> 5
Rw 5
B6.129P2(C)-Igf2<tm4
.1Wrk>/H 		Igf2<tm4.1Wrk> 7Loss of Igf2 imprinting.Order From EMMA
Igf2 7
STOCK Igf2<tm4Wrk>/H Igf2<tm4Wrk> 7Intra-uterine growth restriction (paternal transmission).Order From EMMA
STOCK Foxq1<sa> Bloc
1s5<mu>H 		Bloc1s5<mu> 13sa: silky coat with a high sheen, mu/mu have fur of a muted brown colour.Order
Foxq1<sa> 13
STOCK Foxq1<sa> Bloc
1s5<mu> Ap3b1<pe-H>/H 		Foxq1<sa> 13satin, muted, pearl stock.Order
Bloc1s5<mu> 13
SAA2 None. Order From EMMA
C3;CAnNCrl-Sagg/H Sagg 1Heterozygotes have loose skin that can be identified by weaning age. Their dermal phenotype is similar to some of the subtypes of Ehlers Danlos syndrome (EDS) and cutis laxa. Breeding data indicate that Sagg/+ has reduced penetrance and/or reduced viability - circa 75 percent. Litters from intercrosses failed to produce any pups with a more severe phenotype than that seen with heterozygotes, and litter size was markedly smaller than expected. Taken together this suggests that homozygotes are lost prenatally, but this has not formally been shown. Sagg maps to chromosome 1, lying between D1Mit232 and D1Mit234.Order From EMMA
C57BL/6Apb-Rc3h1<san
>/Apb 		Rc3h1<san> 1Autoimmune disease, ANA, lymphadenopathy, splenomegaly, hyper IgG, SLE.Order From EMMA
C57BL/6-Rc3h1<san>/H Rc3h1<san> 1Autoimmune disease, ANA, lymphadenopathy, splenomegaly, hyper IgG, SLE.Order From EMMA
SB1 Reduced hearing by clickbox.Order
C3H;B6-SB2/1/H Reduced hearingOrder From EMMA
C3H101HF1 x STOCK Sh
by<2H>/H 		Shby<2H> 17Curly whiskers/absent at birth. Sporadic lack of fur growth. Some growth retardation from birth. Heterozygotes and homozygotes not easily distinguishable - limited breeding data suggest that homozygotes are smaller. Homozygotes viable and fertile. On outcrossing Shby/Shby<2H>, Shby/+ and Shby<2H>/+ offspring could not be distinguished. Allelism tests with Shby gave 0/49 recombinants showing that Shby<2H> is allelic with Shby. Linkage cross with T gave 6/57 recombinants (10.5 cM) i.e. very similar to T-Shby (10.8 cM).Order From EMMA
C3H101H-scb/H scb 8Scabby.Order
STOCK Scr/H Scr 6Scruffy.Order
B6;129P2-Scube3<tm1D
gen>/H 		Scube3<tm1Dgen> 17No visible phenotype.Order From EMMA
SCW Severe immunodeficiency.Order
STOCK Sd/H Sd 2Urogenital abnormalitiesOrder
SDL Myo5a<d-l> 9Dilute coat. The colour of d<l>/ d<l> is identical to that of d/d but the mice develop a severe neuro-muscular disorder characterised by convulsions and opisthotonas (arching upwards of the head and tail) and they die at about 3 weeks.Order
Bmp5<se> 9
Myo5a<d> 9
B6Dnk;B6N-Secisbp2<t
m1a(EUCOMM)Wtsi>/H 		Secisbp2<tm1a(EUCOMM
)Wtsi> 		13Potential EUMODIC data in the Europhenome database.Order From EMMA
C3;B6-Setx<K1261E>/H Setx 2No phenotype data recorded.Order
C3;B6-Setx<L2137S>/H Setx 2No phenotype data recorded.Order
C3;C-Setx<M401K>/H Setx 2No phenotype data recorded.Order
C3;B6-Setx<S2124P>/H Setx 2No phenotype data recorded.Order
C3;B6-Setx<V1058I>/H Setx 2No phenotype data recorded.Order
C3;B6-Setx<V1307A>/H Setx 2No phenotype data recorded.Order
C3;B6-Setx<V44E>/H Setx 2No phenotype data recorded.Order
C3H;C-Sbc/H Sbc 16Identified in circadian rhythm screen. These mice change their period length from normal to long after a light pulse is given at CT16 (circadian time).Order From EMMA
C3H;C-Heph<Sla>/H Heph<Sla> XHeterozygous females have striped coats. Males are small and pale at birth and most die within 1 week of birth. Females are classed at 8 days of age. Sla is an X linked dominant and classed as a harmful mutant due to lethality of males.Order From EMMA
C3H101H-Pax6<Sey-3H> Pax6<Sey-3H> 2Small at birth and weaning with small eyes, white feet and sometimes a belly spotOrder
C3H101HF1 x STOCK Pa
x6<Sey-H>/H 		Pax6<Sey-H> 2Small-eye.Order From EMMA
a<t> 2
129-Foxp3<sf>/H Foxp3<sf> Xscurfy, scaliness first of tail later other parts of body, skin tight, eyelids open late, males usually die before / shortly after weaning, survivors small & sterile, small abdominal tetsis & lack scrotum. Occasional sf females are X/O resemble sf males. Similar human disease: Ichthyosis and Male HypogonadismOrder
C3H101HF1 x STOCK Fo
xp3<sf>/H 		Foxp3<sf> XHeterozygous males can first be recognised at about 11 days of age by a reddening of the genital papilla. They develop scaliness first of the tail and later of other parts of the body. The skin appears tight and the eyelids open late. Scurfy males usually die before or shortly after weaning; survivors are small and sterile. Occasional scurfy females have proved to be X/O and resemble scurfy males. Heterozygous females are indistinguishable from homozygous wild-type females.Order From EMMA
C3H;C-Sfrp2<C50F>/H Sfrp2<C50F> 3Normal.Order
Sfrp2<l153N Sfrp2<I153N> 3Order
B6.Cg-Sfrp2<I153N>/H Sfrp2<I153N> 3No overt Phenotype. Full description available from Europhenome. Order
B6.Cg-Sfrp2<C50F>/H Sfrp2<C50F> 3Order
B6.Cg-Sfrp5<Q27stop>
/H 		Sfrp5<Q27stop> 19Order
C3H101H-Segd/H Segd 5Small: at birth about 75% the weight of wild-type sibs and only 55% by weaning. Progressive hairloss (from 3 weeks of age) with accompanying thickening of the skin. Homozygotes die as small moles.Order
STOCK Shby/H Shby 17Shabby. Patchy coat, tail rough. Cyclic epilation. Spontaneous, fully penetrant dominant mutation that affects the hair, skin and growth of affected animals. Homozygotes have very shortened and mis-shapen whiskers, heterozygotes have bent, but full length whiskers. Both homs and hets have abnormal fur development: first growth of hair being thinner than normal. After the first moult, the fur becomes very sparse; hair growth and loss continues in cycles in heterozygotes whereas adult homozygotes remain almost naked. The skin of Shby/Shby show areas of acanthosis and hyperkeratosis, the keratin having a flaky appearance. The dermis shows a marked increase in inflammatory infiltrate. Heterozygotes show similar changes to homozygotes, but less severe. At weaning, Shby/+ are approximately 80% and Shby/Shby 65% of the weight of their wild-type littermates.Order
Sherbert Order
C3H.C-Sfl/H Sfl 2Identified in circadian rhythm screen. Mice carrying this mutation have no phase shifting response to a light pulse given at CT16. Order From EMMA
C3H.C-Sci/H Sci 8Identified in circadian rhythm screen. Short circadian period of wheel-running activity (22.5 hrs rather than 23.5 hrs). Wheel running activity is about 10% of control animals.Order From EMMA
Shp2CS x DO11.10 L1 Characterisation of the phenotype is still in progress, but the line displays amplified cytokine secretion in response to antigenic challengeOrder
Shp2CS x DO11.10 L5 Characterisation of the phenotype is still in progress, but the line displays amplified cytokine secretion in response to antigenic challengeOrder
Shp2CSxB10.BR Line 1 Characterisation of phenotype still in progress but line displays defective primary immune responses to T-dependent antigen and amplified cytokine secretion in response to antgenic challenge.Order From EMMA
C3;CAnNCrl-Sic/H Sic 7Sickly. Classed as harmful. Heterozygotes are small and sickly. Mutation has not been tested for homozygosity. The Sickly mice are marginally smaller than wildtype sibs at birth, and dramatically smaller (<50%) at weaning. The nature of this growth defect has yet to be investigated. Heterozygous mice are also prone to infection.Order From EMMA
Pde6b<rd1> 5
Tyr<c> 7
Tyrp1<b> 4
SIG Grid2<Lc> 6Mitf<Mi-wh> is semidominant. The homozygotes are viable white mice, the eyes are pink at birth. The heterozygotes have light sandy coats and belly spots. Grid2<Lc> is homozygous lethal, the heterozygotes have swaying hindquarters and jerky up and down movement. Sig is homozygous lethal, the heterozygotes are blind, the eyes are open at birth, some exhibit hydrocephaly.Order
Mitf<Mi-wh> 6
Sig 6
C3H101H-skimp/H skimp 7Order
C3;C-Jag1<Slalom>/H Jag1<Slalom> 2These mice exhibit head weaving and shaking behaviour.Order From EMMA
Tyr<c> 7
Pde6b<rd1> 5
Tyrp1<b> 4
B6.129P2-Slc38a4<tm2
Kel>/Kel 		None, a minor effect on term weight.Order From EMMA
C57BL/6NTac-Slc40a1<
tm1a(EUCOMM)Hmgu>/H 		Slc40a1<tm1a(EUCOMM)
Hmgu> 		1Potential EUMODIC data in the Europhenome database.Order From EMMA
B6;129P2-Slc7a10<tm1
Dgen>/H 		Slc7a10<tm1Dgen> 7No visible phenotype.Order From EMMA
C3H101H-Pou3f4<Slf>/
H 		Pou3f4<Slf> Xsex-linked fidgetOrder
Slip Order
C3H.C-Sgh/H Sgh 4Mice carrying this mutation demonstrate a low endurance of wheel running activity which is reduced to about 10% of control values.Order From EMMA
129-Smad<tm3Rob>/H Smad2<tm3Rob> 18None.Order From EMMA
Smad2 18
STOCK Smad2<tm5(SMAD
2)Rob>/H 		Smad2 18Embryonic lethal at day 8.5 dpc.Order From EMMA
STOCK Smad2<tm6(SMAD
2)Rob>/H 		Smad2 18Homozygous lethal at day 8.5.Order From EMMA
STOCK Smad<tm4(SMADH
3)Rob>/H 		Smad2<tm4(SMADH3)Rob
> 		18Approx 50% of homozygotes are embryonic lethal at 15d, remainder are viable as adults.Order From EMMA
Smad2 18
Smad8 conditional Smad9 3NoneOrder From EMMA
STOCK Smad9<tm1Rob>/
H 		Smad9<tm1Rob> 3NoneOrder From EMMA
C3H101H-Sme/H Sme Reduction in size of pinna and often irregular in shape.Order
B6;CBA-Tg(SMN*E134K)
1Pks/H 		None.Order From EMMA
SMN2 low Tg(SMN2)89Ahmb Mice that are homozygous for the targeted mutant Smn1 allele and carry the SMN2 transgene exhibit symptoms and neuropathology similar to patients afflicted with type I proximal spinal muscular atrophy (SMA) but die at P6. (See Monani 2000 HMG 9 333-339). Mice homozygous for Smn1-/-, in the absence of SMN2 would die before birth. Heterozygotes for the knockout show no phenotype.Order
Smn1<tm1Msd> 13
STOCK Smn1<tm1Msd> T
g(SMN2)89Ahmb Tg(SMN*E134K)1Pks/H 		Mice that are homozygous transgenic for SMN2 and SMN134K and heterozygous or Wt for the Smn knockout allele have no phenotype. Mice that are homozygous transgenic for SMN2 and SMN134K and homozygous deleted for the Smn knockout allele die at approximately P0.Order From EMMA
FVB.Cg-Tg(SMN1*delta
5-Smg6)1Pks/H 		None.Order From EMMA
STOCK Smn1<tm1Msd> T
g(SMN2)89Ahmb Tg(SMN1*delta5-Smg6)1Pks/H 		Smn1<tm1Msd> 13Rescues post natal lethality of SMN2 low strain Order From EMMA
Tg(SMN2)89Ahmb
Tg(SMN2)89Ahmb UN
B6NTac;B6N-Smoc1<tm1
a(EUCOMM)Wtsi>/H 		Smoc1<tm1a(EUCOMM)Wt
si> 		12Potential EUMODIC data in the Europhenome database.Order From EMMA
B6Dnk;B6N-Smpdl3b<tm
1a(EUCOMM)Wtsi>/H 		Smpdl3b<tm1a(EUCOMM)
Wtsi> 		4Potential EUMODIC data in the Europhenome database. Order From EMMA
B6.129P2-Tg(EEF1A1-S
ocs6)1Pwg/H 		Tg(EEF1A1-Socs6)1Pwg 10% increased body weight & increased insulin sensitvity.Order From EMMA
sooty foot soo 2Order
STOCK Sox4<m91Ark> F
oxq1<sa>/+ +/H 		Sox4<m91Ark> 13Embryonic lethal - fully penetrant. Dies approximately 14.5 dpc of heart defect.Order From EMMA
Foxq1<sa> 13
B6;129P2-Sox9<tm1Gsr
>/H 		Sox9<tm1Gsr> 11Heterozygous and homozygous Sox9-flox mice are viable, fertile and appear normal. They can be used to conditionally inactivate Sox9 by crossing with cre recombinase-expressing mice.Order From EMMA
B6Dnk;B6N-Sp2<Gt(EUC
J0012h08)Hmgu>/H 		Sp2<Gt(EUCJ0012h08)H
mgu> 		11Order From EMMA
C3H;C-Spgl/H Tyrp1<b> 4Heterozygotes have polydactyly of the hind limbs. Homozygotes have polydactyly of all four limbs.Order From EMMA
Tyr<c> 7
Pde6b<rd1> 5
C3H.Cg-Celsr1<Scy>/H Celsr1<Scy> 15Mice carrying this mutation exhibit circling behaviour.Order From EMMA
Pde6b<rd1> 5
Tyr<c> 7
Tyrp1<b> 4
Ssm Shsm 4Shaker small.Order
Ssy Small syndactyly.Order
C57BL/6NTac-Chrna9<t
m2a(EUCOMM)Wtsi>/H 		Chrna9<tm2a(EUCOMM)W
tsi> 		5Potential EUMODIC data in the Europhenome database.Order From EMMA
STOCK Dmd<mdx> Tg(te
tO-Utrn)1Ked/H 		Dmd<mdx> XThis stock contains a tetracyclin inducible utrophin transgene when crossed with MCK-tTA mice.Order From EMMA
Tg(tetO-Utrn)1Ked UN
C3H101H-Nsdhl<Str-1H
>/H 		Nsdhl<Str-1H> XstriatedOrder From EMMA
B6.Cg-Ndrg1<str>/H Ndrg1<str> 15Mice at first develop normally but around the age of 5-6 weeks develop a peripheral demyelinating neuropathy resulting in weakness of the hind limbs. This manifests as clasping hind legs when suspended by tail, marked tremor, inability to maintain normal posture. Signs progress rapidly at first, stabilise after 20 weeks.Order From EMMA
C3H101H-Nsdhl<Str-2H
>/H 		Nsdhl<Str-2H> XstriatedOrder
C3H;C-Strg/H Strg XStriped and greasy.Order
STOCK Sts<->/H Order
STOCK Stpy/H Stpy XStpy/Y are thought to die around mid-gestation. Stpy/+ typically have a striped appearance by 10 days of age. Weight data indicate that heterozygotes are more than 15% lighter than +/+ sibs at birth and about 10% lighter at weaning. Nearly 50% of Stpy/+ are lost before birth. The Stpy mutation is a circa 2 cM deletion that encompasses Rps6ka3 and Pdha1 (Blair et al HMG, 1998, 7, 3, 549-555)and is therefore a possible model for Coffin-Lowry syndrome and lactic acidosis.Order
Stpy X
STOCK Myo6<sv>/H Myo6<sv> 9Order
Col4a1<Svc> Col4a1<Svc> 8Small with vacuolar cataract.Order
C3H101H-Dync1h1<Swl>
/H 		Dync1h1<Swl> 12Sprawling, abnormal posture and locomotion from defective position sense mainly affecting hind limbs, myelination deficient, deficiency of sensory receptors, spindles virtually absent from hind limbs.Order From EMMA
SWR/OlaHsd Tyr<c> 7Order
Sxr Eda<Ta-33H> XSxr: transposition of a duplication of part of the short arm to the pseudoautosomal region of long arm of the Y chromosome. The duplication contains Sry and all Yp genes required for spermatogenesis up to the round spermatid stage and other genes including Zfy1, Zfy2, Ube1y1 and Smcy. XX<Sxr> outwardly develop as males, but are usually sterile. By non-random X-inactivation, fertile females carrying Sxr may be produced e.g. by using T16H to produce X(T16H)/X<Sxr> females.Order
Tp(Y)1Ct<Sxr-a> Y
C3H101HF1 x STOCK Ed
a<Ta> Tp(Y)1Ct<Sxr-b>/H 		Tp(Y)1Ct<Sxr-b> YSxr<b> is derived from Sxr<a> by what is thought to be an aberrant recombination event between Zfy-1 and Zfy-2. Unlike Sxr<a>, Sxr<b> does not produce seroligically detectable H-Y antigen.Order
Eda<Ta> X
sy<a> Shaker with syndactylism Albany. Order
B6;129P2-Sycn<tm1Rja
>/H 		Sycn<tm1Rja> 7Pancreatic secretion compromised.Order From EMMA
C3H101HF1 x STOCK +
T(10;13)199H +/Edar<dl> + Kitl<Sl-con>/H 		Kitl<Sl-con> 10Order
T(10;13)199H 13
C3H;101H-T(10;18)18H
/H 		T(10;18)18H 18Order
STOCK Edar<dl> T(10;
18)18H/H 		Edar<dl> 10Order
C3H101H-T(11;13)41Ad Order
C3H101H-Wnt3<vt>T(11
;13)41Ad/H 		Wnt3a<vt> 11Order
a<t> 2
Edn3<ls> 2
Myo5a<d> 9
C3H101H-T(11;13)56H/
H 		T(11;13)56H 13Order
C3H101H-T(11;19)42H/
H 		T(11;19)42H 19Order
STOCK T(13;14)69H/H T(13;14)69H 14Order
STOCK Hr<hr>T(14;15)
6Ca/+ +/H 		Hr<hr> 14Order
T(14;15)6Ca 15
T(14;15)6Ca 15
CBA/H-T(14;15)6Ca Order
STOCK T(1;10)73H/H Order
C3H101H-T(1;12)52H/H Order
STOCK T(1;13)70H Order
JUN-T(1;2)5Ca Order
C3H101H-T(1;4)71H/H Order
C3H101H-T(1;6)42Ad/H T(1;6)42Ad 6Order
C3H101H-T(1;7)49H Order
C3H101H-T(1;8)63H Order
C3H101H-T(2;11)30H Gdf5<bp> 2Order
T(2;11)30H - cross 4 T(2;11)30H 11Order
C3H101H-T(2;14)48H a<t> 2Order
C3H101H-T(2;15)45Ad/
H 		Order
STOCK-T(2;16)28H T(2;16)28H 16Order
STOCK-T(2;19)68H Gdf5<bp-H> 2Order
Bloc1s6<pa> 2
Mlph<ln> 1
STOCK T(2;3)24H/H T(2;3)24H 3Order
C3H101H-T(2;4)13H/H T(2;4)13H 4Order
C3H101HF1 x STOCK Sd
T(2;4)1Ca a<t> +/+ + a Tyrp1<b>/H 		Tyrp1<b> 4Order
a<t> 2
T(2;4)1Ca 4
STOCK Pldn<pa> T(2;4
)1Go/H 		Bloc1s6<pa> 2Order
STOCK T(2;4)1Sn Tyrp1<b> 4Order
STOCK T(2;5)72H/H T(2;5)72H 5Order
C3H101H-T(2;6)7Ca Gr
id2<Lc> Mitf<Mi-wh>/+ + +/H 		Grid2<Lc> 6Order
Mitf<Mi-wh> 6
T(2;6)7Ca 6
T(2;8)26H Bloc1s6<pa> 2Order
Gdf5<bp-H> 2
STOCK T(2;8)2Wa/H Bloc1s6<pa> 2Order From EMMA
a<t> 2
Edn3<ls> 2
Tyr<c> 7
T(2;8)2Wa 8
STOCK T(2;9)11H a Gd
f5<bp>/H 		Gdf5<bp> 2Order
Mlph<ln> 1
T(2;9)11H 9
C3H101H-T(3;10)61H Order
C3H101H-T(3;12)58H Order
C3H101HF1 x STOCK T(
3;19)25Ad/H 		T(3;19)25Ad 19Order
C3H101H-T(3;8)56Ad/H Order
C3H101H-T(4;10)Hsc76
H/H 		Head shaker, circling.Order
C3H101HF1 x STOCK a<
e> Tyrp1<b> + Dock7<m>/+ T(4;12)47H Dock7<m>/H 		Tyrp1<b> 4Order
T(4;12)47H 12
C3H101H-T(4;5)46H Order
C3H101H-T(4;6)77H/H Tyr<c-ch> 7Homozygotes are sometimes infertile.Order
T(4;6)77H 6
C3H101HF1 x STOCK T(
4;6)77H Mitf<Mi-wh>/H 		Mitf<Mi-wh> 6Homozygotes sometimes infertile.Order
T(4;6)77H 6
T(4;8s)36H Tyrp1<b> 4Order
a<e> 2
STOCK T(4;9)45H Tyrp1<b> 4Order
C3H101HF1 x STOCK Eg
fr<wa2> T(5;11)57H +/Egrf<wa2> + Wnt3a<vt>/H 		Egfr<wa2> 11Semi-sterile.Order
Wnt3a<vt> 11
T(5;11)57H 11
C3H101H-T(5;12)31H Order
STOCK T(5;13)264Ca Kit<W-bd> 5Order
C3H101H-T(5;7)30Ad Order
C3H101H-T(6;12)32H/H Order
C3H101H-T(6;13)6Ad Order
C3H101H-T(6;14)39H/H Order
STOCK T(6;7)51H Order
T(6;8)2Ad Mc1r<E-so> 8Order
T(6;8)2Ad 8
C3H101HF1 x STOCK T(
7;11)40Ad/H 		Egfr<wa2> 11Order
Wnt3a<vt> 11
Tyr<c-ch> 7
T(7;11)40Ad 11
STOCK T(7;11)65H Tyrp1<b> 4 Reciprocal translocationOrder
a<t> 2
Edn3<ls> 2
Ednrb<s> 14
C3H101H-T(7;13)7Ad/H Order
STOCK T(7;15)/H Gpi1<a> 7Heterozygotes are semi-sterile.Order
Tyr<c> 7
Slc45a2<uw> 15
Krt71<Ca-d> 15
STOCK T(7;16)67H/H T(7;16)67H 16Order
STOCK T(7;19)145H/H T(7;19)145H 19Male sterile.Order From EMMA
T(7;19)145H 19
C3H101H-T(9;10)62H/H T(9;10)62H 10Order
STOCK T(9;17)138Ca T(9;17)138Ca 9Order
T(9;17)138Ca 17
C3H101H-T(In1;5)44H Kit<W-bd> 5Order
STOCK T(X;11)38H +/+
Otc<spf>/H 		Otc<spf> XOrder
T(X;11)38H 11
STOCK T(X;4)37H +/+
Otc<spf>/H 		Otc<spf> XOrder
STOCK T(X;7)3Neu Order
C57BL/6Apb-Lcp2<twm>
/Apb 		Lcp2<twm> 11Few naïve CD4+ and CD8+ T cells, autoimmunity, 5fold decrease in DP Tcells. Defects in positive selection & reduced negative thymocyte selection, hypergammaglobulinemia and hyper-IgE.Order From EMMA
T<21H> T<21H> 17Effects like brachyuryOrder From EMMA
Adamts20<bt-H> 15
t<h20> 17
C3H101HF1 x STOCK T<
22H> +/+ Itpr3<tf>/H 		T<22H> 17T<22H>/t<6> males have enhanced transmission ratioOrder
C3H101H-T<24H>/H T<24H>/t<h2> seen to be tailless, thus showing mutation to be an allele of brachyury. Outcrosses of original mutant male to 3H1 females produced 125 T<24H>/+ and 127 +/+ demonstrating that penetrance of the mutation is high and that viability of heterozygotes is normal. Both male and female heterozygotes were shown to be fertile. Homozygotes were not investigated.Order
C3H101H-T<25H>/H brachyury, sometimes slightly small mice with shortened, kinky tails. Males breed satisfactorily but females show impaired transmission producing few T<25H> offspring which have low viability. Homozygote presumed lethal.Order
C3H101H-T<26H>/H T<26H> 17Brachyury. Viability of both heterozygous females and males is good as is the penetrance of the mutation. Homozygotes not investigated. Shown to be an allele of brachyury as T<26H>/t mice are tailless.Order
C3H101HF1 x STOCK T<
29H>/H 		T<29H> 17Order
C3H101HF1 x STOCK T<
30H> +/+ Itpr3<tf>/H 		T<30H> 17Order
Itpr3<tf> 17
C3H101HF1 x STOCK T<
31H>/H 		T<31H> 17Short tailsOrder
C3H101HF1 x STOCK T<
32H> +/+ Itpr3<tf>/H 		T<32H> 17Heterozygotes - short tail, homozygotes - lethal.Order
Itpr3<tf> 17
tf 17
C3H101HF1 x STOCK T<
33H> +/+ Itpr3<tf>/H 		T<33H> 17Heterozygotes have short tails. Homozygous lethal. Bergstrom et al (1998) Genetics (PMID:9755211).Order
Itpr3<tf> 17
tf 17
C3H101HF1 x STOCK T<
34H> +/+ Itpr3<tf>/H 		T<34H> 17Heterozygotes - short tail, Homozygotes - lethal.Order
Itpr3<tf> 17
tf 17
C3H101H-T<36H>/H T<36H> 17Short tailsOrder
STOCK t<6>/H t<6> 17Taillessness with TOrder
C3H101HF1 x STOCK T<
c-2H> Itpr3<tf>/+ Itpr3<tf>/H 		T<c-2H> 17taillessOrder
Itpr3<tf> 17
tf 17
C3H101H-T<c>/H T<c> 17T<c>/+ and T<c>/t<h7> tailless. T<c>/T<c> lethal, like T/T but more severely affectedOrder From EMMA
C3H101HF1 x STOCK T
t<h17> T(1;17)190Ca +/+ + + Itpr3<tf>/H 		t<h17> 17Order
T(1;17)190Ca 17
t<h18> t<h2> t<h18> 17Gives tailless with T. Homozygotes for t<h18> are lethal. t<h18> carries distal distortion D2 and t<h2> carries responder R.Order
t<h2> 17
STOCK t<h20> t<h20> 17Order
T<21H> 17
STOCK t<h44> t<h44> 17T/t<h44> taillessOrder
STOCK t<h49> t<h49> 17Order
STOCK t<h50> t<h50> 17Order
STOCK t<h51> t<h51> 17Order
t<h51>t<h18> t<h18> 17Lethal when homozygous.Order
t<h51> 17
t<lowH> 17
C3H101HF1 STOCK t<h5
7>/H 		t<h57> 17t-Harwell 57 - a distal partial t-haplotype and thought to carry the t<6> lethal factor and distal distorter but not responder. Unlike t<h7>, t<h57> does not carry the tail shortening suppressing effect, nor are Tt<h57>/++ tailless. Breeding data suggest that Tt<h57>/t<w18> males have reduced fertility; females are fertile. Crosses of Tt<h57>+/++tf males to ++tf/++tf showed no evidence of transmission distortion, and generated 17 recombinants between T and tf out of 543 mice scored. The reciprocal generated 78 recombinants out of 1037 mice scored, indicating a higher level of recombination in females.Order
STOCK t<h7> t<h7> 17t-Harwell-7. Arose by recombination from t<6>. As with t<6>, it is considered to lack the most proximal region of of the t complex including Tcd1. It also carries the t<6> recessive lethal factor - homozygotes die in utero. Unlike t<6>, it suppresses the tail shortening effect of T rather than enhancing it. Heterozygous males are susceptible to premature death due to sudden urinary obstruction. The novel phenotype of t<h7> is postulated to be caused by a duplication. See Lyon M.F. Genet Res 67:249-256.Order
t<h7m2> t<h7m2> 17t<h7m2> is derived from t<h7>, but has lost the harmful effects on male fertility. Unlike T/t<h7> which have normal tails, T/t<h7m2> are tailless. t<h7m2> suppresses recombination between T and tf. Moderately high transmission of t<h7m2> is seen from heterozygous males. Homozygotes are lethal. t<h7m2>, at time of testing in 1990s, was indistinguishable from t<6> from which t<h7> arose.Order
t<h7m> T<21H> 17t-complex Harwell 7 mutation: arose by recombination from t<h7>. Unlike t<h7>, t<h7m> homozygotes are viable and have normally fertility, and males do not suffer from sudden urinary obstruction. Also, unlike t<h7>, t<h7m> enhances rather than suppresses the tail shortening effect of T (T/t<h7m> mice are tailless). t<h7m> does not suppress recombination between T and tf, and the transmission ratio from heterozygous males is normal.Order
t<h7m> 17
STOCK Del(17)T<hp> +
/+ Itpr3<tf>/H 		Del(17)T<hp> 17Order
Itpr3<tf> 17
tf 17
t<hr15> t<hr15> 17t-Harwell-recombinant 15. Arose by recombination from a T t<h50> +/+ t<w18> tf female mated to a + + tf/+ + tf male. Recombinant haplotype shown to carry the t<6> lethality locus, but not the t<w18> lethality locus. In crosses of T+/t<hr15> tf males to +tf/+tf females, t<hr15> was shown to be transmitted to over 95% of the offspring. t<hr15> gave a transmission ratio of approx 35% with t<lowH> in compound heterozygous males. T<hr15> carries the responder region of t<w5> origin. T+/+t<hr15> mice are tailless.Order
t<hr1> t<hr1> 17t-Harwell-recombinant 1. Arose by recombination from a T t<h18> +/+ t<w18> tf female mated to a + + tf/+ + tf male. Recombinant haplotype shown to carry the t<6> lethality locus, but not the t<w18> lethality locus. In crosses of T+/t<hr1> tf males to +tf/+tf females, t<hr1> was shown to be transmitted to over 90% of the offspring. t<hr1> carries the t<w5> responder (with only the distal region of t<6> origin) and gave a transmission ratio of 35-40% with t<lowH> (see Lyon & Zenthon (1987) Genet Res Camb 50, 29-34 & Lyon (1990) Genet Res Camb 55, 13-19). T+/+t<hr1> mice are tailless.Order
t<hr4> t<hr4> 17Arose by recombination from a t<h7> +/t<w18> tf female mated to a T tf/+ tf male. Recombinant offspring was tailless, but not tufted (N. B. T/t<h7> are not tailless) - this recombinant haplotype was given the nomenclature t<hr4>. Intercrosses of t<hr4> heterozygotes to t<6> heterozygotes failed to produce any compound heterozygotes indicating that t<hr4> carries the t<6> lethality locus. In accord with this, intercrosses of t<hr4> heterozygotes failed to produce any homozygotes. However, t<hr4>/t<w18> was shown to be viable, indicating that t<hr4> does not carry the t<w18> lethality locus. Crosses of T tf/t<hr4> + males to + tf/+ tf females generated 24 t<hr4> +/+ tf and 1 T tf/+ tf showing high transmission ratio distortion in favour of the t<hr4> haplotype from males.Order
t<low2H> t<low2H> 17Arose by recombination from t<h2>/t<h17>. Partial haplotype carrying the responder from t<6>, but having wild-type distorter loci at D1, D2 and D3 as described by Lyon & Zenthon (1987) Genet Res 50, 29-34. T/t<low2H> short-tailed rather than tailless. t<low2H>/t<low2H> are viable and fertile. When opposite a wild-type allele, males were shown to transmit t<low2H> to about 25% of their offspring; when opposite t<h2> this rose to about 50%, and opposite t<h51>t<h19> gave about 95% transmission.Order
t<low3H> t<low3H> 17Order
STOCK t<lowH> t<lowH> 17Order
STOCK t<lub2>/H t<Lub2> 17Order
STOCK t<s6>/H t<s6> 17Order
STOCK t<w32>/H t<w32> 17Order
C3H101HF1 x STOCK t<
w32m>/H 		Order
t<x507> TailessOrder
Ta<10H> Muth1 XWas originally thought to be a mutation at the tabby locus. However, stock notes indicate that Dr M.F. Lyon showed mutation not to be allelic with tabby - and suggested may be an allele of Bpa. Breeding data indicate that hemizygous males die prenatally and approx 25% of heterozygous females are missing at birth. Viability of heterozygotes between birth and weaning is good.Order
Muth1 X
C3H101H-Eda<Ta-23H>/
H 		Eda<Ta-23H> XOrder
Ta<23H> Xce<c> Pgk1<
a> 		Eda<Ta-23H> XOrder
Xic<c> X
C3H101H-Eda<Ta-25H>/
H 		Eda<Ta-25H> XtabbyOrder
C3H101H-Eda<Ta-26H>/
H 		Eda<Ta-26H> XTabby, has a hairy tail.Order
C3H101H-Eda<Ta-27H>/
H 		Eda<Ta-27H> XTabby. The males have hairless tails.Order
C3H101HF1 x STOCK Ta
<28H>/H 		Eda<Ta-28H> XTabby. The males have hairless tails, some have eyes open at birth.Order
C3H101HF1 x STOCK Ed
a<Ta-29H>/H 		Eda<Ta-29H> XTabby, males have hairless tails.Order
C3H101H-Eda<Ta-30H>/
H 		Eda<Ta-30H> XTabby.Order
C3H101H-Eda<Ta-32H>/
H 		Eda<Ta-32H> XtabbyOrder
C3H101H-Eda<Ta-33H>/
H 		Eda<Ta-33H> Xtabby, hairy tail and the teeth do not need cuttingOrder
C3H101H-Ta<35H>/H Eda<Ta-35H> XTabby, males have hairless tails and are bald behind the ears.Order
C3H101H-Eda<Ta-36H>/
H 		Eda<Ta-36H> XTa<36H>/Y males have hairy tails; viability is good and shown to be fertile. Ta<36H>/+ also fertile and have good viability, but penetrance of phenotype slightly reduced. Ta<36H>/Ta<36H> not investigated.Order
C3H101H-Eda<Ta-37H>/
H 		Eda<Ta-37H> XTabby males have hairless tails and bald patches behind ears.Order
C3H101H-Eda<Ta-38H>/
H 		Eda<Ta-38H> XVery extreme looking tabby: eyes are closed, teeth require cutting, hairless tail.Order
C3H101H-Eda<Ta-39H>/
H 		Tabby.Order
C3H101HF1 x STOCK Ta
<43H>/H 		Stripped coat in hemizygous females and males carrying the mutation. Mice carrying the mutation may also exhibit reduced eyelid opening, fewer vibrissae and defects of teeth and exocrine glands. Homozygous females are often sterile.Order From EMMA
C3H;C-Ta<44H>/H Ta<Fa> like ie heterozygous females-striped, hemizygous males have no guard hairs, bald tails often with kink near tip, very little hair behind ears. Limited breeding data suggest good viability of both heterozygous females and hemizygous males. Penetrance of mutation would also appear to be good.Order From EMMA
C3H101H-Tal/H Tal 14Heterozygotes cannot easily be identified at birth but can be classified at weaning. The feet are held in an abnormal position, there is soft tissue syndactylism involving digits 2,3, and to a lesser degree 4, and there is often overgrowth and twisting of the toenails. The forefeet are less obviously affected than the hindfeet. Homozygotes are more severely affected with extreme shortening of the phalanges and significant reduction to the metatarsals. The tail shows a kinking to form a hook near the tip.Order
C3H.Cg-Foxq1<sa> Tas
16/H 		Curly tail in heterozygous(?) animals.Order From EMMA
C3H;C-TAS2/H Belly spot, head spot, white feet (variable).Order From EMMA
C3H;C-Tas4/H Multiple white spotting over entire bodyOrder From EMMA
TAS6 Belly spot, white feet, head spotOrder From EMMA
tcl<6> Order
C3H101H-Tcx/H Striped coats in females, greasy coat in males.Order
C3H101H-Ebp<Td>/H Ebp<Td> XTattered.Order From EMMA
Grxcr1<pi-tde> Grxcr1<pi-tde> 5Insertional mutation - Tasmanian devilOrder
C3H101H A/A<w>-Tesa/
H 		Tesa Mice carrying this mutation are deaf, have short tails and exhibit circling behaviour.Order From EMMA
Tesod-36 Order
TESOD-37 Order
129S2.Cg-Gnas<tm2Kel
>/H 		There is a behavioural phenotype: response to novel environments as measured through activity in various tasks. This targeted allele has been shown to represent a null for Nesp55 protein.Order From EMMA
TFH Order
TFH/H T 17Shorter tail, blunt.Order From EMMA
Itpr3<tf> 17
TFL Order
C3H101HF1 x STOCK a/
a Cacna1a<tg>/H 		Cacna1a<tg> 8Tottering phenotype. Homozygotes have wobbly gait from 3-4 weeks and intermittant seizures. Heterozygotes appear normal.Order
a 2
Tg(-214VpreB1-huCD12
2)F133Lmb 		No known effectsOrder From EMMA
Tg(5'lambda 5-huCD25
)82Lmb 		No known effectsOrder
Tg(PRNP*)1896Pcg Overexpression of transgenic bovine PrPC in brain and other tissues, in order to confer increased susceptibility to TSE diseases, including BSE, compared to wild-type mice.Order From EMMA
Tg(PRNP*)2010Pcg Overexpression of transgenic bovine PrPC in brain and other tissues, in order to confer increased susceptibility to TSE diseases, including BSE, compared to wild-type mice.Order From EMMA
Tg(PRNP*)2019Pcg Overexpression of transgenic bovine PrPC in brain and other tissues, in order to confer increased susceptibility to TSE diseases, including BSE, compared to wild?type mice.Order From EMMA
B6;CBACa-Tg(tetO/CMV
-CFTR)TC35Clh/H 		Tg(tetO/CMV-CFTR)TC3
5Clh 		NoneOrder From EMMA
Tg(PRNP*)K6M16Pcg Prnp<tm1Cwe> 2Overexpression of transgenic kudu PrPC in brain and other tissues, in order to confer increased susceptibility to TSE diseases, including BSE, compared to wild-type mice. Tg(KuPrP)K6M16 mice are hemizygous for the transgene.Order From EMMA
STOCK Tg(PRNP*)K6M6P
cg/Pcg 		Overexpression of transgenic kudu PrPC in brain and other tissues, in order to confer increased susceptibility to TSE diseases, including BSE, compared to wild-type mice.Order From EMMA
Tg(Leftb-cre)1Hmd Tg(Leftb-cre)1Hmd Order
Tg(Nmnat1)7104Cole None.Order
Tg(OvPrP)EF50 Overexpression of transgenic ovine PrPC in brain and other tissues of this mouse line in order to confer increased susceptibility to TSE diseases compared to wild-type mice.Order From EMMA
Tg(OvPrP)EM16 A ~12 kb transgene, comprised of chimaeric DNA sequence encoding a sheep PrP (AHQ allele) coding region and mouse PrP gene promoter and 3' UTR, was used to microinject pronuclear stage FVB/N fertilised oocytes.Order From EMMA
Tg(OvPrP)EM52 Overexpression of transgenic ovine PrPC in brain and other tissues in order to confer increased susceptibility to TSE diseases compared to wild-type mice. The Tg(OvPrP)EM52 line is hemizygous for the transgene.Order From EMMA
Tg(OvPrP)FF8 Overexpression of transgenic ovine PrPC in brain and other tissues in order to confer increased susceptibility to TSE diseases compared to wild-type mice.Order From EMMA
Tg(OvPrP)FM16 Overexpression of transgenic ovine PrPC in brain and other tissues in order to confer increased susceptibility to TSE diseases compared to wild-type mice.Order From EMMA
Tg(OvPrP)FM18 Overexpression of transgenic ovine PrPC in brain and other tissues in order to confer increased susceptibility to TSE diseases compared to wild?type mice.Order From EMMA
B6CBACa-Tg(RP1-309F2
0*)48Kel/H 		Tg(RP1-309F20*)48Kel Order From EMMA
Tg(RP1-309F20*)48Kel UN
B6.Cg-Tg(RP3-340H11)
29Kel/H 		Tg(RP3-340H11)29Kel Mild hyperglycaemia in neonates, mildly impaired glucose tolerance post weaning.Order From EMMA
Tg(RP3-340H11)29Kel UN
STOCK Tg(runx1/MTG8)
ICH10Fc/H 		Order
STOCK Tg(runx1/MTG8)
ICH11Fc/H 		Order
STOCK Tg(runx1/MTG8)
ICH12Fc/H 		Order
STOCK Tg(runx1/MTG8)
ICH7Fc/H 		Order
STOCK Tg(runx1/MTG8)
ICH8Fc/H 		Order
STOCK Tg(runx1/MTG8)
ICH9Fc/H 		Order
Tg(Sox2-cre)1Amc Tg(Sox2-cre)1Amc Order
Tg(T-cre)1Lwd Tg(T-cre)1Lwd Order
Tg(TH1-TauV337m)T39 Development of abnormal tau phosphorylation & aggregation within the brain, as seen in Alzheimer's & other tauopathies. Highly discrete & specific age-dependent cognitive changes including memory impairment & impaired impulse control.Order
B6.Cg-Tg(Wnt1-cre)11
Rth/H 		Tg(Wnt1-cre)11Rth Order
129-Tgfbr2<tm1Roes>/
RoesH 		Tgfbr2<tm1Roes> 9Order From EMMA
TgH(cited2)2SB Homozygous null mice are embryonic lethalOrder
STOCK Epo<Tg(SV40T/E
po)134.3LCPjr>/H 		Epo<Tg(SV40T/Epo)134
.3LCPjr> 		Homozygotes have incomplete epo deficiency and are anaemic.Order From EMMA
Tg(bTGTRfs)1Vkc Order
TgN(CEB1GEN)-G NoneOrder
TgN(CEB1GEN)-H NoneOrder
TgN(CEB1GEN)-I NoneOrder
B6C3-Tg(HD82Gln)81Db
o/H 		Tg(HD82Gln)81Dbo Onset of abnormal gait and tremors at 3 months. Fail to gain weight from 2 months.Order
B6CB-Tg(PMP22)C1Clh/
H 		Tg(PMP22)C1Clh Order
B6;CBACa-Tg(PMP22)C2
2Clh/H 		Tg(PMP22)C22Clh Shaking & unsteady gait.Order From EMMA
B6CB-TgN(PMP22)C58Cl
h/H 		Order
B6CB-Tg(PMP22)C61Clh
/H 		Order
B6CB-Tg(PMP22)JP18Cl
h/H 		Order
(B6xCB)F2-Tg(PMP22)M
Y41Clh/H 		Tg(Pmp22)My41Clh Shaky & unsteady gait.Order
B6CB-Tg(pUHG16)JU2Cl
h/H 		NoneOrder
B6CB-Tg(yCFTR)A10Clh
/H 		NoneOrder
B6CB-Tg(yCFTR)T30Clh
/H 		Order
B6CB-Tg(yCFTR)T57Clh
/H 		None.Order
Tg(Nmnat1)881Cole None.Order
C57BL/6-Hnrpll<thdr>
/Apb 		Hnrpll<thdr> 17A marked reduction in the no. of peripheral T cells, especially naïve CD4 & CD8 cells, and poor survival of thunder T cells upon adoptive transfer. The T cells are hyperactivated.Order From EMMA
Tiffany Mice exhibit eye defects. Sections of the lens diffract light differently.Order
C57BL/6JApb-Lig4<tin
y>/Apb 		Lig4<tiny> 8Small in size, no CD8 cells or B cells, TCR Tg appears to rescue T cells. Similar to human SCID.Order From EMMA
C57BL/6JApb-Lig4<tin
y>/Apb 		Lig4<tiny> 8Small in size, no CD8 cells or B cells, TCR Tg appears to rescue T cells. Similar to human SCID.Order From EMMA
Zfp36l1<tm1Tnr> Zfp36l1 12Day 9 embryonic lethal.Order
C3H101H-Tks/H Tks 9tail kinks Order
B6.129P2-Tln1<tm4.1C
rit>/Crit 		Tln1<tm4.1Crit> 4The homozygous floxed Tln1 mice are viable and fertile and exhibit not evidence of any phenotype.Order From EMMA
B6.129-Tln2<tm2Crit>
/CritH 		Tln2<tm2Crit> 9The homozygous Tln2(cd) mice are viable and fertile, and exhibit no evidence of any phenotype.Order From EMMA
B6.129P2-Tln1<tm1Cri
t>/CritH 		Tln1<tm1Crit> 4Order From EMMA
129/SvEv-Tln1<tm1Cri
t>/CritH 		Tln1<tm1Crit> 4Order
STOCK tlss/H tlss Thymo lymph sarcoma susceptibility. Affected animals usually have an enlarged spleen, thymus and mesenteric lymph nodes. Blockage of the intestine due to the failure of peristalsis is also common - this may be the most frequent cause of death within the stock. Affected animals usually succumb within 20 weeks. Outcrosses to C3H/HeH and JUW produced no affected offspring, suggesting that susceptibility is due to a recessive trait, however it may be dominant, but with reduced penetrance on a partial C3H/HeH or JUW genetic background.Order
TM/45 Abnormal response to Intraperitoneal Glucose Tolerance Test at 24 weeks of age.Order From EMMA
C3H;B6-TM47/H Mutant mice fail to bury marbles in sawdust when left for a period of 30 minutes. Order From EMMA
C3H;B6-TM58/H These mice have an abnormal walking posture, appearing as though the hips are fused. Histological examination shows this to be a muscular phenotype.Order From EMMA
TM/59 Abnormal response to Intraperitoneal Glucose Tolerance Test at 12 weeks of age. Fasting hyperinsulinaemia at 16 weeks. Mice are significantly heavier than wildtype at 12 and 16 weeks of age.Order From EMMA
TM/60 Abnormal response to Intraperitoneal Glucose Tolerance Test at 12 weeks of age. Abnormal IPGTT and fasting hyperinsulinaemia at 16 weeks. Mice are significantly heavier than wildtype at 12 and 16 weeks of age.Order From EMMA
C3H;B6-TM13/H Head bobbingOrder From EMMA
TM2 Behavioural/low anxiety phenotypeOrder From EMMA
C3H;B6-TM4/H High T60 in intraperitoneal glucose tolerance tests.Order From EMMA
B6;129P2-Tmem67<tm1D
gen>/H 		Tmem67<tm1Dgen> 4No visible phenotype.Order From EMMA
C3H;B6-TMR10/H Mutant mice fail to bury marbles in sawdust when left for a period of 30 minutes.Order From EMMA
Tmsb4x<tm1Tnr> Tmsb4x XB-cell defect.Order From EMMA
To Cat5<To2> 10Order
STOCK Lim2<To3>/H Lim2<To3> 7Total opacity, dominant cataract.Order From EMMA
B6;129P2-Tpcn1<tm1Dg
en>/H 		Tpcn1<tm1Dgen> 5No visible phenotype.Order From EMMA
TPL Order
129-Tpm1<tm1a(EUCOMM
)Wtsi>/WtsiH 		Tpm1<tm1a(EUCOMM)Wts
i> 		9Potential EUMODIC data in the Europhenome database.Order From EMMA
C3H.C-Pmp22<Tr-1H>/H Pmp22<Tr-1H> 11Tremors with seizures. Tremors, muscle weakness.Order From EMMA
C3H.C-Pmp22<Tr-2H>/H Pmp22<Tr-2H> 11Tremors, muscle weakness.Order From EMMA
C3H101H-Trf<bm>/H Order
B6;129P2-Trpc4<tm1Dg
en>/H 		Trpc4<tm1Dgen> 3No visible phenotype.Order From EMMA
B6.129P2-Trpc4<tm1Dg
en>/H 		Trpc4<tm1Dgen> 3No visible phenotype.Order From EMMA
B6;129P2-Trpc6<tm1Dg
en>/H 		Trpc6<tm1Dgen> 9No visible phenotype.Order From EMMA
C3H101H-Tsk2/H Tsk2 1Heterozygotes can be recognised at 1 to 2 weeks of age by a tightness of the skin across the shoulders when picked up. The mice are fully viable and fertile. Order From EMMA
C57BL/6N-Prss50<tm1a
(EUCOMM)Hmgu>/H 		Prss50<tm1a(EUCOMM)H
mgu> 		9Potential EUMODIC data in the Europhenome database.Order From EMMA
Tyr<c-37Hch> Tyr<c-ch37H> 7Tyr<c-ch37H>/Tyr<c-ch37H> looks like Tyr<c-ch>/Tyr<c-ch>Order
Tyr<c-38Hch Tyr<c-ch38H> 7(hair - colour, eye - colour) chinchilla. Tyr<c-ch38H>/Tyr<c-ch> & Tyr<c-ch38H/Tyr<c-ch38H> look like Tyr<c-ch>/Tyr<c-ch>.Order
C3H101H-Tyr<c-40H>/H Bmp5<se> 9(hair - colour, eye - colour, behaviour - sight) albinoOrder
a 2
Tyr<c-40H> 7
Tyr<c-42H> Tyr<c-ch> 7(hair - colour, eye - colour, behaviour - sight) albino. Homozygotes have reduced viability or are not viable.Order
Tyr<c-42H> 7
Tyr<c-43H> Tyr<c-ch> 7(hair - colour, eye - colour, behaviour - sight) albinoOrder
Tyr<c-43H> 7
STOCK Tyr<c-44H>/Tyr
<c-ch>/H 		Tyr<c-44H> 7(hair - colour, eye - colour, behaviour - sight) albinoOrder
Tyr<c-ch> 7
C3H101HF1 x STOCK Ty
r<c-45H>/H 		Tyr<c-45H> 7(hair - colour, eye - colour, behaviour - sight) albino.Order
C3H101H-Tyr<c-46H> Tyr<c-46H> 7(hair - colour, eye - colour, behaviour - sight) albinoOrder
C3H101H-Tyr<c-47H>/H Tyr<c-ch> 7(hair - colour, eye - colour, behaviour - sight) albinoOrder
Tyr<c-47H> 7
Tyr<c-49Hch> Tyr<c-ch49H> 7Homozygotes look somewhat mottled up to weaning and whiter than Tyr<c-ch>/Tyr<c-ch>. Tyr<c-ch49H>/Tyr<c> also mottled and with very white bellies.Order
Tyr<c-50H> Tyr<c-50H> 7(hair - colour, eye - colour, behaviour - sight) albinoOrder
Tyr<c-51H> Tyr<c-51H> 7(hair - colour, eye - colour, behaviour - sight) albinoOrder
Tyr<c-54Hch> Tyr<c-ch54H> 7(hair - colour, eye - colour) chinchillaOrder
Tyr<c-55H> Tyr<c-ch> 7(hair - colour, eye - colour, behaviour - sight) albinoOrder
Tyr<c-55H> 7
C3H101HF1 x STOCK Ty
r<c-em>/H 		Tyr<c-em> 7(hair - colour, eye - colour) chinchilla extreme mottled. Extreme dilution of coat.Order From EMMA
Tyrp1<b> 4
Ednrb<s> 14
STOCK a/a Tyr<c-ch>/
Tyr<c-m> Ednrb<s>/+/H 		Tyr<c-m> 7(hair - colour, eye - colour) chinchilla mottled. Homozygotes and c<m>/c<ch> have chinchilla-type fur patches of lighter fur similar to that of c/c<ch>. The two genotypes are distinguishable by the whiter belly of c<m>/c<m> mice.Order
Tyr<c-ch> 7
C3H101HF1 x STOCK Ty
r<c-r>/H 		Tyr<c-r> 7(hair - colour, eye - colour) ruby-eyedOrder
C3H101HF1 x STOCK Ty
rp1<b-55H>/H 		Tyrp1<b> 4(hair - colour) brown.Order
Tyrp1<b-55H> 4
STOCK Tyrp1<b-65H>/H Tyrp1<b> 4(hair - colour) brown. Tyrp1<b-65H>/Tyrp1<b>: brown fur, small ears, domed head, small. Tyrp1<b-65H>/Tyrp1<b-65H>: not investigated.Order
Tyrp1<b-65H> 4
C58.Cg-Tyrp1<B-lt>/T
yrp1<b>/H 		Tyrp1<B-lt> 4(hair - colour) heterozygotes have light underfur, homozygotes almost white hair except tips. GVSLM3 Vol3:85Order
Tyrp1<b> 4
B6;129S6-Rr4<tm1Hgc>
/H 		Rr4<tm1Hgc> XTo date this mouse strain does not have an overt phenotype.Order From EMMA
STOCK Ufde/H Ufde Affected individuals have one or both ears low set and reduced in size. Affected offspring are usually small, some have fused toes. Proportion of affected offspring is small, and of those many die at birth. Litter sizes of affected males outcrossed to wild-type females are smaller than should be expected suggesting prenatal loss, but this has not been investigated. Affected females often fail to breed or breed poorly.Order
Ufde UN
C3H101H-Lnp<Ul>/H Lnp<Ul> 2Ulnaless.Order
UMLC-TM/12 Statistically lowered body weight & plasma levels of glucose after an overnight fast at 12 & 16 wks of age. DEXA at 14 wks: decreased body weight, lean & total tissue, BMD & BMC.Order
UMLC-TM/6 Statistically elevated body weight & plasma levels of glucose, leptin & adiponeptin after an overnight fast at 12 & 16 wks of age. In addition elevated levels of insulin at 16wks of age. DEXA at 14wks: increased fat mass & % fat.Order
C57BL/6JApb-Card11<u
nm>/Apb 		Card11<unm> 5The mice make poor antibody responses, and as they age they develop atopic dermatitis and hyper-IgE, with red itchy ears & weepy eyes, progressing to badly eroded skin from itching.Order From EMMA
C57BL/6NTac-Uros<tm1
a(EUCOMM)Wtsi>/H 		Uros<tm1a(EUCOMM)Wts
i> 		7Potential EUMODIC data in the Europhenome database.Order From EMMA
Utrn<+/-> Abnormal neuromuscular junction morhpology.Order
Utrn<-/-> Abnormal neuromuscular junction morhpology.Order
STOCK Cdh23<v-Alb>/W
tsiH 		Cdh23<v-Alb> 10Waltzer Albany.Order From EMMA
C3;CAnNCrl-Vng/H Vng 5Small. One low ear.Order From EMMA
Tyr<c> 7
Pde6b<rd1> 5
Tyrp1<b> 4
VANIMMA Under investigation: not severely immunocompromised.Order
B6.129P2-Vnn1<tm1Pna
>/H 		Vnn1<tm1Pna> 10 Order
B6.129P2-Vnn1<tm1Pna
>/H 		Vnn1<tm1Pna> 10 Order
B6CB-Tg(Vav1-NPM1/AL
K)1Sudt/H 		Tg(Vav1-NPM1/ALK)1Su
dt 		Mice develop lymphoid tumours from 6 months of age.Order From EMMA
Tg(Vav1-NPM1/ALK)1Su
dt 		UN
B6;129P2-Vipr1<tm1Dg
en>/H 		Vipr1<tm1Dgen> 9No visible phenotype.Order From EMMA
STOCK Vm/H Vm 17 Visceral myopathy. Off white coat colour, intestinal problems in some animals. Older animals develop tremors. A high proportion of Vm/+ males are sterile. Heterozygotes are on average about 10% smaller than wild-type sibs at birth and nearer 15% smaller by weaning. Homozygotes die soon after birth with major kidney abnormalities. Vm has been mapped to proximal Chr17: T - 7.0 cM +/- 1.4 cM - Vm - 6.5cM +/-1.6cM -tf. D17Mit114 and D17Mit44 are not deleted in the Vm mice.Order
VM/Dk Tyrp1<b> 4Order
Tyr<c> 7
Myo5a<d> 9
H2<b> 17
STOCK Kit<W>/H Kit<W> 5Dominant white spottingOrder
B6129-Tg(Wap-cre)117
38Mam/JH 		Tg(Wap-cre)11738Mam There is no abnormal phenotype. Albino, black or white bellied Agouti.Order
Ward Wines 5 Small increase in kidney size, possible late-onset cyst formation.Order
C3;C-Egfr<Wa5>/H Egfr<Wa5> 11Small eyes, eyes open at birth, curly whiskers and coat. Heterozygotes have open eyelids and curly whiskers at birth. The first coat has a crimped appearance and subsequent coats are wavy/rough.Order From EMMA
C3H/HeH-Wc2/H Wc2 Mice carrying this mutation have a wavy coat.Order From EMMA
Wc2 UN
C3.CAnNCrl-Whto/H Whto 7White toes. Heterozygous Whto mice display white belly spots and/or white toes. Homozygotes would appear to be embryonic lethal.Order From EMMA
STOCK Whrn<wi>/H Whrn<wi> 4Deaf, head tossing and circling. Whirler.Order From EMMA
Wnt2b Wnt2b 3No visible phenotypeOrder
STOCK Wnt3a<vt>/H Wnt3a<vt> 11Vestigial tail (2) Homozygotes have very short tails, varying form complete absence to about half normal length.Order
STOCK Wnt3a<vt> Foxq
1<sa> Bloc1s5<mu>/H 		Bloc1s5<mu> 13Vestigial tail.Order
Wnt3a<vt> 11
Foxq1<sa> 13
C3H101H-Eef1a2<wst>/
H 		Eef1a2<wst> 2Wasted homozygotes can be recognised at 20 days of age by tremor and uncoordinated body movements. They develop progressive paralysis and do not survive beyond 30 days. The wasted heterozygotes have normal viability. Also contains Ra. The ragged heterozygotes have thin, ragged coats. The homozygotes are almost naked and are semi-lethal.Order
Sox18<Ra> 2
B6.129-Wt1<tm1Hst>/H Wt1<tm1Hst> 2No detectable WT* protein isoforms by western blot. No overt phenotype.Order From EMMA
C57BL/6NTac-Wtap<tm1
a(EUCOMM)Hmgu>/H 		Wtap<tm1a(EUCOMM)Hmg
u> 		17Potential EUMODIC data in the Europhenome database.Order From EMMA
C3H101HF1 x STOCK Xi
c<a>/H 		Xic<a> XOrder
STOCK Xic<a>Pgk1<a>/
H 		Xic<a> XOrder
Xce<b> Atp7a<Mo-blo> Atp7a<Mo-blo> XOrder
Xic<b> X
Xce<b> Pgk1<a> Xic<b> XOrder
Xce<b>, Ta<Fa> Xic<b> XOrder
Xce<c> Pgk1<b> Xic<c> XOrder
CBB10-Tg(myl2-cre)11
18Tmhn/H 		Tg(myl2-cre)1118Tmhn Heart (myocardial)-specific CRE driver line (uniform expression of Cre throughout myocardial tissue)Order From EMMA
Tg(myl2-cre)1118Tmhn UN
STOCK Eda<Ta>Atp7a<M
o-Blo>/H-XO 		Eda<Ta> XOrder
Atp7a<Mo-blo> X
C3H101H-Xpna/H Xpna XAnaemia in females, seen at birth to 2 days old and may be small. Males die pre-natally. Order From EMMA
B6Dnk;B6N-Xylb<tm1a(
EUCOMM)Hmgu>/H 		Xylb<tm1a(EUCOMM)Hmg
u> 		9Potential EUMODIC data in the Europhenome database.Order From EMMA
Y<d-1> Del(Y)1H YY<d-1> is a deletion on the small arm of the Y chromosome. XY<d-1> and XXY<d-1> mice develop as females. Multi-copy gene Rbm is partially deleted as are Sx1 sequences on Y. This results in the Sry gene being located closer to the centromere and may be the cause of the repression of Sry. Sry repression has been shown to be more extreme in Y<d-1> bearing mice than those with Y<d-2>, Y<d-3> and Y<d-5>. No XY<d-1> or XXY<d-1> hermaphrodites have been identified. XY<d-1> females are fertile, but with reduced fertility. XXY<d-1> have normal fertility. XYY<d-1> were typically shown to have reduced testis size and breeding data suggest that they are all sterile. See Capel et al (1993) Nat Gen 5, 301-307. Laval et al (1995) Proc Natl Acad Sci 92, 10403-10407.Order
Del(Y)1H Y
Y<d-2> Del(Y)2H YY<d2> is a deletion on the small arm of the Y chromosome. XY<d2> and XXY<d2> mice develop as females. Multi-copy gene Rbm is partially deleted as are Sx1 sequences on Y<d2>. This results in the Sry gene being located closer to the centromere and may be the cause of the repression of Sry. Sry repression has been shown to be less extreme in Y<d2> bearing mice than those with Y<d1>. About 10% of XXY<d2> develop as hermaphrodites. XY<d2> females are fertile, but with reduced fertility. XXY<d2> have normal fertility. XYY<d2> were typically shown to have reduced testis size and breeding data suggest that they are all sterile.Order
Y<d-3> Del(Y)3H YY<d3> is a deletion on the small arm of the Y chromosome. XY<d3> and XXY<d3> mice develop as females. Multi-copy gene Rbm is partially deleted as are Sx1 sequences on Y<d3>. This results in the Sry gene being located closer to the centromere and may be the cause of the repression of Sry. Sry repression has been shown to be less extreme in Y<d3> bearing mice than those with Y<d1>. About 10% of XXY<d3> develop as hermaphrodites. XXY<d3> have normal fertility; XY<d3> are also fertile. XYY<d3> were typically shown to have reduced testis size and breeding data suggest that they are all sterile.Order
Y<d-5> Del(Y)5H YThe aberrant Y chromosome was generated via recombination from a male that carried Sxr on its X chromosome and a Y chromosome of AKR strain origin. Site of recombination on the Y chromosome occurred with the Rbm gene family sequences on Yp. Crosses with males with a marked X chromosome to XXY<d5> females produced only two males (both XXY) out of 351 that may have carried Y<d5>, and four identified hermaphrodites. Thus Y<d5> is a very poor promoter of male development. About 2% Y<d5> carrying mice exhibit hermaphroditism.Order
Del(Y)5H Y
Y<d-6> Del(Y)6H YThe aberrant Y chromosome was generated via recombination from a male that carried Sxr on its X chromosome and a Y chromosome of AKR strain origin. Along with Y<d1>, Y<d6> has a larger deletion of the multi-gene family Rbm than Y<d2>, Y<d3> and Y<d5>. No hermaphroditism has been seen with mice carrying the Y<d6> chromosome. XY<d6> & XXY<d6> animals develop as females.Order
Del(Y)6H Y
Y<d4> Del(Y)4H YStock where males carry a Y chromosome of SWR strain origin that visually looks shorter than normal and, as a result, is assumed to have a compromised Sry locus. Crosses(1) of +/Y<SWR-YD4> to C57BL/6 or closely related strains yielded 573 offspring that looked female, 170 that looked male and 4 of indeterminate gender. Similar crosses (2) to 3H1 and C3H/HeH gave 121 offspring that looked female and 106 that looked male. Openings (C57BL/6 females crossed to +/Y<SWR-YD4>) indicated no prenatal loss. Cytogenetic examination of 55 'females' from cross (1) indicated that 40 were XX, 1 XO and 14 XY<SWR-YD4>. These data suggest that on a predominantly C57BL/6 background nearly 50% of XY<SWR-YD4> develop looking outwardly like females. On a mixed C3H/HeH & 101/H background breeding data suggest that fewer, if any, XY<SWR-YD4> mice look outwardly female.Order
Del(Y)4H Y
STOCK X/Y<317.1m>/H Stock carrying a recombinant Y chromosome (Y<dr1>) generated by recombination between the small arm of a Y chromosome of M. m. domesticus (AKR strain) origin and an X chromosome carrying Sxr (M. m. musculus derivation). Y<dr1> has Smcy and Zfy-1 of domesticus origin; Rbm, Sry and Zfy-2 have been shown to be of domesticus origin. Crosses of males XY<dr1> to C57BL/6J females gave 176 females and 173 males; 18 of these females were tested and confirmed XX. XY<dr1> have normal testes weights and are fertile. Thus Sry functioning appears normal on Y<dr1>.Order
STOCK X/Y<316.1h>/H Stock carrying a recombinant Y chromosome (Y<dr2>) generated by recombination between the small arm of a Y chromosome of M. m. domesticus (AKR strain) origin and an X chromosome carrying Sxr (M. m. musculus derivation). Y<dr2> has centromere and some Rbm sequences of domesticus origin, Sry,Zfy-2, Smcy, Zfy-1 and some Rbm sequences of musculus origin. Therefore the recombination event that generated this Y chromosome occurred within the Rbm seqences. Crosses of males XY<dr2> to C57BL/6J females gave 163 females and 131 males (chi squared = 3.483,p=0.062); 7 of these females were tested and confirmed XX. Combining data from crosses to B6 and 3H1 gave 213 females and 158 males (chi squared 8.15, p=0.004) suggesting that Y<dr2> may have slightly impaired Sry function; however Xy<dr1> have normal testes weights and are fertile.Order
STOCK X/Y<317B.4f>/H Stock carrying a recombinant Y chromosome (Y<dr3>) generated by recombination between the small arm of a Y chromosome of M. m. domesticus (AKR strain) origin and an X chromosome carrying Sxr (M. m. musculus derivation). Y<dr3> has centromere and some Rbm sequences of domesticus origin, Sry,Zfy-2, Smcy, Zfy-1 and some Rbm sequences of musculus origin. Therefore the recombination event that generated this Y chromosome occurred within the Rbm seqences. Crosses of males XY<dr3> to C57BL/6J females gave 193 females and 174 males (chi squared = 0.984, p=0.321); 5 of these females were tested and confirmed XX. XY<dr3> testes weights are normal. Therefore appears that Sry on Y<dr3> functions normally.Order
STOCK X/Y<317B.4h>/H Stock carrying a recombinant Y chromosome (Y<dr4>) generated by recombination between the small arm of a Y chromosome of M. m. domesticus (AKR strain) origin and an X chromosome carrying Sxr (M. m. musculus derivation). Y<dr4> has centromere, Rbm, Sry and Zfy-2 of domesticus origin, Smcy and Zfy-1 of musculus origin. Crosses of males XY<dr4> to C57BL/6J females gave 134 females and 138 males; 9 of these females were tested and confirmed XX. XY<dr4> testes weights are normal. Therefore appears that Sry on Y<dr4> functions normally.Order
STOCK Dp(Y)1H Dp(Y)1H YStock carrying a recombinant Y chromosome (Y<dr5>) generated by recombination between the small arm of a Y chromosome of M. m. domesticus (AKR strain) origin and an X chromosome carrying Sxr (M. m. musculus derivation). Y<dr5> has centromere and Rbm of domesticus origin, and Zfy-1 of musculus origin. Sry, Zfy2 and Smcy have sequences of both domesticus and musculus origin indicating that the recombinant Y has a tandem duplication of this region. Crosses of males XY<dr5> to C57BL/6J females gave 159 females and 167 males (chi squared = 0.196, p = 0.658). XY<dr5> testes weights are normal. Therefore appears that Sry on Y<dr5> functions normally.Order
Dp(Y)1H Y
C57BL/6J-Chr Y<POS>/
H 		May show XY sex reversal and hermaphroditism.Order
C3H;C-Ankrd11<Yod>/H Tyr<c> 7Craniofacial, broad face. Heterozygotes (Ankrd11<Yod>/+) have readily distinguishable craniofacial features. Further to this, abnormal bone morphology including an abnormally small growth plate, negligible chondrocyte hypertrophy and a dramatically reduced zone of woven bone formation have been detected.Order
Tyrp1<b> 4
Ankrd11<Yod> 8
Pde6b<rd1> 5
C3H.Cg-Ankrd11<Yod>/
H 		Ankrd11<Yod> 8Craniofacial, broad face. Heterozygotes (Ankrd11<Yod>/+) have readily distinguishable craniofacial features. Further to this, abnormal bone morphology including an abnormally small growth plate, negligible chondrocyte hypertrophy and a dramatically reduced zone of woven bone formation have been detected.Order From EMMA
STOCK Tg(Igf2/LacZ,H
19)YZ15Aco/AcoH 		Investigating how expression of Igf2 and H19 are regulated is of relevance to understanding Beckwith Weidemann syndrome. The physiological impact of over expressing H19 is not fully characterised. Unlike low copy number lines, the Igf2 LacZ gene does not show appropriate reciprocal imprinting in YZ15 mice as it is expressed from both parental alleles.Order From EMMA
STOCK Tg(Igf2/LacZ,H
19)YZ17Aco/AcoH 		Investigating how expression of Igf2 and H19 are regulated is of relevance to understanding Beckwith Weidemann syndrome. The physiological impact of over expressing H19 is not fully characterised. Deletion of the intergenic region with Cre recombinase results in partial (mesoderm specific) reactivation of Igf2 LacZ expression following maternal transmission.Order From EMMA
STOCK Tg(Igf2/LacZ,H
19)YZ20Aco/AcoH 		Investigating how expression of Igf2 and H19 are regulated is of relevance to understanding Beckwith Weidemann syndrome. The physiological impact of over?expressing H19 is not fully characterised. Order From EMMA
STOCK Tg(Igf2/LacZ,H
19)YZ46Aco/H 		Investigating how expression of Igf2 and H19 are regulated is of relevance to understanding Beckwith Weidemann syndrome. The physiological impact of over expressing H19 is not fully characterised.Order From EMMA
STOCK Tg(Igf2/LacZ,H
19)YZ8Aco/AcoH 		Investigating how expression of Igf2 and H19 are regulated is of relevance to understanding Beckwith Weidemann syndrome. The physiological impact of over expressing H19 is not fully characterised. The imprinted H19 gene is only expressed when transmitted through the maternal germline. After paternal transmission the gene is repressed. The Igf2 LacZ gene shows appropriate reciprocal imprinted behaviour (paternal allele specific expression, maternal repression). Order From EMMA
ZA1 a<e> 2Order
Tyrp1<b> 4
Tyr<c-ch> 7
Dock7<m> 4
C3H101HF1 x STOCK a<
t>Tyrp1<b-cH>Tyr<c-ch>/H 		a<t> 2Order
Tyr<c-ch> 7
Tyrp1<b-cH> 4
Zfp106<tm1a(KOMP)Wts
i> 		Potential EUMODIC data in the Europhenome database. Order
B6.192P2-Zfp647<Gt(E
S492)1Hgs>/H 		Zfp647<Gt(ES492)Hgs> 15Homozygotes are embryonic lethal at before 6.5 dpc.Order From EMMA
CD1.192P2-Zfp647<Gt(
ES492)1Hgs>/H 		Zfp647<Gt(ES492)Hgs> 15No obvious phenotype in homozygotes.Order From EMMA
B6N-Zfp704<tm1a(EUCO
MM)Wtsi>/H 		Potential EUMODIC data in the Europhenome database. Order
C57BL/6NTac-Zfp715<t
m1a(EUCOMM)Hmgu>/H 		Zfp715<tm1a(EUCOMM)H
mgu> 		7Potential EUMODIC data in the Europhenome database.Order From EMMA
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