Title Phenotype Contact
PDE2A-D479G-CAS-B6N
Allele MGI ID Allele Name Gene MGI ID Gene Name
              MGI:2446107 Pde2a
Contact
PHi Edinburgh high growth line. Contact
PLi Edinburgh low growth line. Contact
Prnp<a(108L_189V)> (DD) No phenotype Contact
Pro-Cre
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:2176182 Tg(Prm-cre)58Og MGI:2176181 Tg(Prm-cre)58Og
None. Contact
R26R-ECFP
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:2449039 Gt(ROSA)26Sor<tm2(ECFP)Cos> MGI:104735 Gt(ROSA)26Sor
None visible. Have the potential to express ECFP in any tissue, upon Cre mediated activation. Contact
R26R-EYFP
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:2449038 Gt(ROSA)26Sor<tm1(EYFP)Cos>              
No reported overt phenotype in the absence of Cre expression. Contact
RAHi Long term growth selected line. Contact
RIII//???
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:3045029 Prnp<a> MGI:97769 Prnp
White mouse. Susceptible to CJD/vCJD disease progression upon exposure to viable prion agents. Contact
ROHi Long term growth selected mouse line. Contact
ROLi Long term growth selected lines. Contact
SAA2
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5759854 Tg(SAA2)1Woo MGI:5759851 Tg(SAA2)1Woo
None. Contact
Sgms1 Knockout 1 EPD0725_2_G05
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:4950245 Sgms1<tm1a(EUCOMM)Wtsi> MGI:2444110 Sgms1
To see phenotype data (when available) visit www.mousephenotype.org Contact
SJL.129(B6)-Nr1i2<tm1Sakl>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:3609633 Nr1i2<tm1Sakl> MGI:1337040 Nr1i2
The PXR regulates the inducible expression of the major drug metabolising cytochrome P450 3a subfamily of enzymes, which are also responsible for the metabolism of elevated levels of bile acids. Knock out animals therefore do not respond to inducers such as pregnenolone 16alpha carbonitrile and show sensitivity to elevated bile acid levels (liver damage). The SJL background shows an unusual constititively high level of portal tract inflammation (Jones DE, Palmer JM, Kirby JA, De Cruz DJ, McCaughan GW, Sedgwick JD, Yeaman SJ, Burt AD, Bassendine MF. Experimental autoimmune cholangitis: a mouse model of immune-mediated cholangiopathy. Liver. 2000 Oct;20(5):351-6.). This strain (along with its wild type) is therefore a model for examining the effects of drugs and bile acids on portal tract inflammation. Contact
SJL/J Lgals1tm1Rob
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:2181809 Lgals1<tm1Rob> MGI:96777 Lgals1
These mice are susceptible to Theiler Murine Encephalomyelitis Virus infection and can be used to model primary progressive multiple sclerosis. During the backcrossing there was high mortality rate amongst litters and very poor breeding due to aversion to other mouse strain pheromones. SJL/J males also exhibited significant aggression often resulting in amyloidosis (sequel of social submissiveness and consequent wounds) in female breeding partners which were often very severe and required culling. Contact
SJL/J Lgals3tm1Poi
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:2183057 Lgals3<tm1Poi> MGI:96778 Lgals3
These mice are susceptible to Theilers Murine Encephalomyelitis Virus infection and can be used to model primary progressive multiple sclerosis. During the backcrossing there was high mortality rate amongst litters and very poor breeding due to aversion to other mouse strain pheromones. SJL/J males also exhibited significant aggression often resulting in amyloidosis (sequel of social submissiveness and consequent wounds) in female breeding partners which were often severe and required culling. Contact
Slc22a6-CreERT2
Allele MGI ID Allele Name Gene MGI ID Gene Name
              MGI:892001 Slc22a6
Heterozygous and homozygous Slc22a6-CreERT2 mice are viable and display no discernible phenotype. Upon administration of tamoxifen recombinase activity is induced specifically in the epithelia of proximal renal tubules. Contact
SPC tetCre loxP VEGF
Allele MGI ID Allele Name Gene MGI ID Gene Name
              MGI:103178 Vegfa
Upon administration of doxycycline, exon 3 of Vegf is deleted from type II alveolar epithelial cells in the lung parenchyma. Contact
StarD10-tg-F10
Allele MGI ID Allele Name Gene MGI ID Gene Name
              MGI:1860093 Stard10
Overexpression of the transgene when crossed with mouse expressing the reverse tetracycline transactivator and given doxycycline (possibility of a tissue specific overexpression). The transgene copy number for this line was evaluated by qPCR and estimated at 25 copies ([23.88 - 25.43], n = 14). The expression level in islets level was measured by western blot after induction by 2g/L doxycycline in drinking water and estimated to be 120% of the control expression. In vivo phenotype: The animals were crossed with RIP7-rtTA mice allowing overexpression of the transgene specifically in pancreatic beta-cells. The doxycycline was added in drinking water (2g/L) from 5 weeks of age and intra-peritoneal glucose tolerance tests (IPGTT, 1g/kg glucose) were performed at 8, 12 and 16-week-old. The resulting line had no differences with control mice on chow diet. This line has not yet been tested on HFD. Contact
StarD10-tg-F3
Allele MGI ID Allele Name Gene MGI ID Gene Name
              MGI:1860093 Stard10
Overexpression/Repression of the transgene when crossed with mice expressing (reverse) tetracycline transactivator and given doxycycline. The transgene copy number for this strain was evaluated by qPCR and estimated to be 15 copies ([14.50 - 16.44], n = 4). The expression level in islets level was measured by western blot after induction by 2g/L doxycycline in drinking water and estimated to be 250 % of the control expression. In vivo phenotype: Crossing with RIP7-rtTA mice allowed overexpression of the transgene specifically in pancreatic beta-cells. The doxycycline was added in drinking water (2g/L) from 5 weeks of age and intra-peritoneal glucose tolerance tests (IPGTT, 1g/kg glucose) were performed at 8, 12 and 16-week-old. The resulting line showed no differences with control mice on chow diet. On high fat diet (65% calories from fat; from 5-week-old) the transgenic mice had a lower weight and better glucose tolerance than control at 16-week-old without significant difference in the intra-peritoneal insulin tolerance test. Contact

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