Title Phenotype Contact
SAA2 None. Contact
Sgms1 Knockout 1 EPD0725_2_G05
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:4950245 Sgms1<tm1a(EUCOMM)Wtsi> MGI:2444110 Sgms1
To see phenotype data (when available) visit www.mousephenotype.org Contact
SJL.129(B6)-Nr1i2<tm1Sakl>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:3609633 Nr1i2<tm1Sakl> MGI:1337040 Nr1i2
The PXR regulates the inducible expression of the major drug metabolising cytochrome P450 3a subfamily of enzymes, which are also responsible for the metabolism of elevated levels of bile acids. Knock out animals therefore do not respond to inducers such as pregnenolone 16alpha carbonitrile and show sensitivity to elevated bile acid levels (liver damage). The SJL background shows an unusual constititively high level of portal tract inflammation (Jones DE, Palmer JM, Kirby JA, De Cruz DJ, McCaughan GW, Sedgwick JD, Yeaman SJ, Burt AD, Bassendine MF. Experimental autoimmune cholangitis: a mouse model of immune-mediated cholangiopathy. Liver. 2000 Oct;20(5):351-6.). This strain (along with its wild type) is therefore a model for examining the effects of drugs and bile acids on portal tract inflammation. Contact
SJL/J Lgals1tm1Rob
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:2181809 Lgals1<tm1Rob> MGI:96777 Lgals1
These mice are susceptible to Theiler Murine Encephalomyelitis Virus infection and can be used to model primary progressive multiple sclerosis. During the backcrossing there was high mortality rate amongst litters and very poor breeding due to aversion to other mouse strain pheromones. SJL/J males also exhibited significant aggression often resulting in amyloidosis (sequel of social submissiveness and consequent wounds) in female breeding partners which were often very severe and required culling. Contact
SJL/J Lgals3tm1Poi
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:2183057 Lgals3<tm1Poi> MGI:96778 Lgals3
These mice are susceptible to Theilers Murine Encephalomyelitis Virus infection and can be used to model primary progressive multiple sclerosis. During the backcrossing there was high mortality rate amongst litters and very poor breeding due to aversion to other mouse strain pheromones. SJL/J males also exhibited significant aggression often resulting in amyloidosis (sequel of social submissiveness and consequent wounds) in female breeding partners which were often severe and required culling. Contact
Slc22a6-CreERT2
Allele MGI ID Allele Name Gene MGI ID Gene Name
              MGI:892001 Slc22a6
Heterozygous and homozygous Slc22a6-CreERT2 mice are viable and display no discernible phenotype. Upon administration of tamoxifen recombinase activity is induced specifically in the epithelia of proximal renal tubules. Contact
SPC tetCre loxP VEGF
Allele MGI ID Allele Name Gene MGI ID Gene Name
              MGI:103178 Vegfa
Upon administration of doxycycline, exon 3 of Vegf is deleted from type II alveolar epithelial cells in the lung parenchyma. Contact
StarD10-tg-F10
Allele MGI ID Allele Name Gene MGI ID Gene Name
              MGI:1860093 Stard10
Overexpression of the transgene when crossed with mouse expressing the reverse tetracycline transactivator and given doxycycline (possibility of a tissue specific overexpression). The transgene copy number for this line was evaluated by qPCR and estimated at 25 copies ([23.88 - 25.43], n = 14). The expression level in islets level was measured by western blot after induction by 2g/L doxycycline in drinking water and estimated to be 120% of the control expression. In vivo phenotype: The animals were crossed with RIP7-rtTA mice allowing overexpression of the transgene specifically in pancreatic beta-cells. The doxycycline was added in drinking water (2g/L) from 5 weeks of age and intra-peritoneal glucose tolerance tests (IPGTT, 1g/kg glucose) were performed at 8, 12 and 16-week-old. The resulting line had no differences with control mice on chow diet. This line has not yet been tested on HFD. Contact
StarD10-tg-F3
Allele MGI ID Allele Name Gene MGI ID Gene Name
              MGI:1860093 Stard10
Overexpression/Repression of the transgene when crossed with mice expressing (reverse) tetracycline transactivator and given doxycycline. The transgene copy number for this strain was evaluated by qPCR and estimated to be 15 copies ([14.50 - 16.44], n = 4). The expression level in islets level was measured by western blot after induction by 2g/L doxycycline in drinking water and estimated to be 250 % of the control expression. In vivo phenotype: Crossing with RIP7-rtTA mice allowed overexpression of the transgene specifically in pancreatic beta-cells. The doxycycline was added in drinking water (2g/L) from 5 weeks of age and intra-peritoneal glucose tolerance tests (IPGTT, 1g/kg glucose) were performed at 8, 12 and 16-week-old. The resulting line showed no differences with control mice on chow diet. On high fat diet (65% calories from fat; from 5-week-old) the transgenic mice had a lower weight and better glucose tolerance than control at 16-week-old without significant difference in the intra-peritoneal insulin tolerance test. Contact
STOCK 129-Rab27b<tm1.2Seab>/SeabH
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:3706986 Rab27b<tm1.2Seab> MGI:1931295 Rab27b
Mice exhibit significant haemorrhagic disease - platelets demonstrated impaired aggregation with collagen and U46619 and reduced secretion of dense granules. The number of dense granules per platelet serotonin content are also reduced. Mice are fertile, have normal life span, seems to be healthy, phenotypically look normal. Contact
STOCK anan/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5568076 anan MGI:5568074 anan
An ENU-induced mutation causing heritable anti-nuclear antibodies with variable penetrance by 12-16 weeks of age. Lymphocyte populations appear grossly normal by flow cytometry. Contact
STOCK anaya/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5568096 anaya MGI:5568094 anaya
An ENU-induced mutation causing heritable anti-nuclear antibodies with variable penetrance by 12-16 weeks of age. Lymphocyte populations appear grossly normal by flow cytometry. Contact
STOCK andra/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5568106 andra MGI:5568104 andra
An ENU-induced mutation causing heritable anti-nuclear antibodies with variable penetrance by 12-16 weeks of age. Lymphocyte populations appear grossly normal by flow cytometry. Contact
STOCK Arap2<Gt(PT1-ATG)9Val>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5514159 Arap2<Gt(PT1-ATG)9AVal> MGI:2684416 Arap2
Normal Contact
STOCK Bhv26/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5646243 Bhv26 MGI:5646241 Bhv26
The alternation score suggest this line has a potential short term working memory deficit. Contact
STOCK bicm2
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:3709881 Mir155<tm1.1Brd> MGI:2676840 Mir155
No overt phenotype reported. Contact
STOCK Bmp7<tm1Rob>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:1857654 Bmp7<tm1Rob> MGI:103302 Bmp7
This strain is a null allele of BMP7 generated by replacing the BMP7 coding sequence by a neomycin cassette. BMP7 is required in the metanephric mesenchyme of the developing kidney to support maintenance of this cell population during organogenesis. Homozygous lethal at birth due to kidney agenesis. Contact
STOCK Bmp7<tm2Rob>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:2136986 Bmp7<tm2Rob> MGI:103302 Bmp7
Homozygous embryonic lethal. Contact
STOCK Cacna2d1<tm1Aschw>/AschwAdlpnH
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:4353680 Cacna2d1<tm1Aschw> MGI:88295 Cacna2d1
Mice homozygous for this mutation exhibit a smooth muscle deficiency and increased urination. Homozygous males are impotent. Cacna2d1<tm1Aschw>/Cacna2d1<tm1Aschw> mice lack gabapentin (GPB) binding sites, show decreased basal myocardial contractility and relaxation, and decreased L-type calcium currents in cardiomyocytes. Homozygous males have reduced mechanosensory responses and delayed development of neuropathic mechanical hypersensitivity following sensory nerve injury. Heterozygotes have no overt phenotype. Contact
STOCK Cdh23<v-Alb>/WtsiH
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:1857310 Cdh23<v-Alb> MGI:1890219 Cdh23
Waltzer Albany. Contact

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