Title Phenotype Contact
STOCK andra/H An ENU-induced mutation causing heritable anti-nuclear antibodies with variable penetrance by 12-16 weeks of age. Lymphocyte populations appear grossly normal by flow cytometry. Contact
STOCK Arap2<Gt(PT1-ATG)9Val>/H Normal Contact
STOCK Bhv26/H The alternation score suggest this line has a potential short term working memory deficit. Contact
STOCK bicm2 No overt phenotype reported. Contact
STOCK Bmp7<tm1Rob>/H This strain is a null allele of BMP7 generated by replacing the BMP7 coding sequence by a neomycin cassette. BMP7 is required in the metanephric mesenchyme of the developing kidney to support maintenance of this cell population during organogenesis. Homozygous lethal at birth due to kidney agenesis. Contact
STOCK Bmp7<tm2Rob>/H Homozygous embryonic lethal. Contact
STOCK Cacna2d1<tm1Aschw>/AschwAdlpnH Mice homozygous for this mutation exhibit a smooth muscle deficiency and increased urination. Homozygous males are impotent. Cacna2d1<tm1Aschw>/Cacna2d1<tm1Aschw> mice lack gabapentin (GPB) binding sites, show decreased basal myocardial contractility and relaxation, and decreased L-type calcium currents in cardiomyocytes. Homozygous males have reduced mechanosensory responses and delayed development of neuropathic mechanical hypersensitivity following sensory nerve injury. Heterozygotes have no overt phenotype. Contact
STOCK Cdh23<v-Alb>/WtsiH Waltzer Albany. Contact
STOCK Col4a1<Raw>/H Retinal ateriolar wiring. Shiny retinal blood vessels. Contact
STOCK Col4a1<Svc>/H Small with vacuolar cataract. Also other eye abnormalities. Mutants are small and bruised at birth and tend to remain small throughout life. Variable eye findings, the most consistent of which is a vacuolar cataract. Other eye findings include enlarged eyes, corneal opacity, iris-corneal adhesions, iris-lens adhesions, retinal vascular abnormalities. Contact
STOCK Dmd<mdx> Tg(Ckm-Dmd_iDp71)MCA-1Chmb/H Contact
STOCK Dmd<mdx> Tg(tetO-Utrn)1Ked/H This stock contains a tetracyclin inducible utrophin transgene when crossed with MCK-tTA mice. Contact
STOCK Dnah11<iv>/H Situs inversus viscerum. Mice show randomisation of situs (sidedness), 50% showing a reversal of their left and right hand sides. Such mice show no obvious deleterious effects. Mice with reversed viscera can be identified as soon after birth as milk has been ingested and until they are 4-5 days old. Using stomach and spleen position mice are classified neonatally for visceral inversions. Contact
STOCK Dync1h1<Loa>/H Legs at odd angle. Contact
STOCK Egr2<tm3Pch> Tg(CD2-cre)4Kio/H Spontaneous autoimmune diseases start at late age (12 months). Contact
STOCK Epo<Tg(SV40T/Epo)134.3LCPjr>/H Homozygotes have incomplete epo deficiency and are anaemic. Contact
STOCK Fgf7<tm1e(EUCOMM)Hmgu>/H Potential EUMODIC data in the <a href=http://www.europhenome.org/databrowser/lineSummary.jsp?epd=HEPD0617_5_F12>Europhenome</a> database Contact
STOCK FKRP<tm1.1Scbr>/H Homozygotes overtly phenotypically normal i.e. this does not mirror the severe clincal course observed in patients with the same mutation. However, mice carrying the Fkrp<tm1Scbr> allele have a phenotype that mirrors muscular dystrophy-dystroglycanopathy: muscle-eye-brain disease in Man. Contact
STOCK Fkrp<tm1Scbr>/ScbrH Homozygotes are smaller than heterozygous littermates and die within the first 24 hours of birth. Both qPCR and western blotting showed that the mutation causes lower expression in homozygotes than seen in wild-type mice. Contact
STOCK Fras1<tm1.1Pjsc>/H No phenotype as homozygous floxed allele; recapitulates constitutive null with ubiquitous Cre driver. The KO mice, when crossed with an ubiquitous cre-driving line, recapitulate the phenotype of blebbed mutant (nonsense mutation in Fras1 gene) and constitute a good model of human Fraser syndrome (skin lesions, kidney and upper airway malformations associated with high neomortality). The blebbed mutant is also archived - see FESA:001391/EM:02533. Contact