Title Phenotype Contact
B6;129-Fshr<tm1Mha>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:2384130 Fshr<tm1Mha> MGI:95583 Fshr
Homozygous males are fertile, but testis weight is reduced (~50% of normal). Homozygous females are infertile, ovulation does not occur. Heterozygous males are indistinguishable from wild type. Contact
B6;129-Gt(ROSA)26Sor<tm1(CAG-Venus/GMNN,Cherry/CDT1)Jkn>/JknH
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5645798 Gt(ROSA)26Sor<tm1(CAG-Venus/GMNN,-Cherry/CDT1)Jkn> MGI:104735 Gt(ROSA)26Sor
The Fucci system was developed by fusing red- and green-emitting fluorescent proteins to the E3 ligase substrates, Cdt1 and Geminin. These fluorescent probes make it possible to distinguish between cells in the G1 or S/G2/M phases of the cell cycle in live cells/tissue (Sakaue-Sawano al 2008). Fucci2a is a bicistronic version of Fucci2 allowing Cre-mediated tissue-specific expression in mice (Mort, R et al 2014). Contact
B6;129-Khdrbs3<tm1Dell>/DellH
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5508245 Khdrbs3<tm1Dell>              
These mice do not express T-STAR protein by Western blotting Contact
B6;129-Nek6<tm1Dgen>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5427679 Nek6<tm1Dgen> MGI:1891638 Nek6
No visible phenotype. Contact
B6;129-P2ry12<tm1Dgen>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5427683 P2ry12<tm1Dgen> MGI:1918089 P2ry12
None Contact
B6;129-Ptprc<tm1Holm>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:1857277 Ptprc<tm1Holm> MGI:97810 Ptprc
Defective lymphocyte development, more severe in T lineage, severe combined immunodeficiency. Contact
B6;129-Reg2<tm1Lchr>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:3812476 Reg2<tm1Lchr> MGI:97896 Reg2
Viable, normal breeding pattern, no obvious phenotype. Contact
B6;129-Scn10a<tm3(cre/ERT2)Jnw>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:3689893 Scn10a<tm3(cre/ERT2)Jnw> MGI:108029 Scn10a
None observed (heterozygous Nav1.8-CreERT2 can express enough Cre to delete the floxed fragment, but it does not affect the expression of Nav1.8 in Nav1.8 positive neurons in DRG). Contact
B6;129-Sync<tm1.1Ked>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:3813569 Sync<tm1.1Ked> MGI:1916078 Sync
No overt phenotype, loss of large calibre motor neurons. Contact
B6;129-Xpa<tm1Hvs>Trp53<tm1holl>Tg(pUR288)1Vij/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:2157167 Trp53<tm1Holl> MGI:98834 Trp53
MGI:1857939 Xpa<tm1Hvs> MGI:99135 Xpa
MGI:3606518 Tg(pUR288)1Vij MGI:3606513 Tg(pUR288)1Vij
Mice that are homozygous for the targeted Trp53 mutation (i.e. Hupki) are healthy, fertile and do not display any gross abnormalities. The expression and functional activity of the chimeric Trp53 gene in homozygous Hupki mice is normal. Homozygous Hupki mice that are also homozygous for the targeted Xpa knockout mutation (i.e. Xpa-Null) are viable and fertile and do not undergo spontaneous tumour development. (However, the stock was not maintained by homozygous matings, but by mating Xpa<tm1Hvs>/+ to +/+). Xpa is required for nucleotide excision repair (NER), therefore Xpa-Null mice and cells are completely deficient in NER. Hupki:Xpa-Null mice and embryo fibroblasts are highly sensitive to carcinogens that generate DNA damage normally repaired by NER (e.g. bulky DNA adducts) compared with Hupki:Xpa-wild-type controls (unpublished data). Contact
B6;129P2-Adamts1<tm1Dgen>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5427602 Adamts1<tm1Dgen> MGI:109249 Adamts1
No overt phenotype reported, however, kidneys seen to be enlarged and fluid-filled in 49 day homozygous mutant females and males. Weight and/or organ weight/body weight ratio increased in 49 day homozygous mutant females and males. Kidney also discoloured in 49 day homozygous mutant male. Histopathology : kidney pelvis dilated, bilateral, 49 day homozygous females and males; unilateral, 49 day homozygous female. Cortex atrophic, 49 day homozygous females and males. MGI states that mice homozygous for targeted mutations at the Adamts1 locus that inactivate the gene display "growth retardation with adipose tissue malformation, impaired female fertility, enlarged renal calices and abnormal adrenal medullary architecture". However, impaired female fertility has not been reported in Adamts1<tm1Dgen> homozygous females. Contact
B6;129P2-Adamts2<tm1Dgen>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5427636 Adamts2<tm1Dgen> MGI:1347356 Adamts2
No overt phenotype. Contact
B6;129P2-Adcyap1r1<tm1Dgen>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5427637 Adcyap1r1<tm1Dgen> MGI:108449 Adcyap1r1
No visible phenotype. Contact
B6;129P2-Adgrg1<tm1Dgen>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5427671 Adgrg1<tm1Dgen> MGI:1340051 Adgrg1
Homozygotes exhibit increased locomotor speed and response to hot plate, they also have abnormal cerellar cortex morphology. Contact
B6;129P2-Adgrl2<tm1Dgen>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5427677 Adgrl2<tm1Dgen> MGI:2139714 Adgrl2
Heterozygotes exhibit hypoactivity. Homozygotes die at circa 15.5 dpc. Contact
B6;129P2-Adgrl4<tm1Dgen>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5427665 Adgrl4<tm1Dgen> MGI:2655562 Adgrl4
None. Contact
B6;129P2-Capn1<tm1Dgen>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5319092 Capn1<tm1Dgen> MGI:88263 Capn1
No overt phenotype. Contact
B6;129P2-Chd4<tm1.1Bh>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5775974 Chd4<tm1.1Bh>              
Both heterozygotes and homozygotes for the floxed allele display no visible phenotype. Heterozygotes for the deleted allele also show no overt phenotype. Homozygotes for the deleted allele die at 3.5 dpc through a failure to develop a trophectoderm and a consequent inability to implant. This strain provides insights into how Chd4 facilitates the first lineage decision making in mammalian embryogenesis. Contact
B6;129P2-Cxcr1<tm1Dgen>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:3604601 Cxcr1<tm1Dgen> MGI:2448715 Cxcr1
No visible phenotype. Contact
B6;129P2-Esr2<tm1Dgen>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5427668 Esr2<tm1Dgen> MGI:109392 Esr2
No visible phenotype. Contact

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