Title Phenotype Contact
B6.129P2-Tln1<tm1Crit>/CritH
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:2429594 Tln1<tm1Crit> MGI:1099832 Tln1
Contact
B6.129P2-Tln1<tm4.1Crit>/Crit
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:3770513 Tln1<tm4.1Crit> MGI:1099832 Tln1
The homozygous floxed Tln1 mice are viable and fertile and have no phenotype. Contact
B6.129P2-Trpc4<tm1Dgen>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5427696 Trpc4<tm1Dgen> MGI:109525 Trpc4
No visible phenotype. Contact
B6.129P2-Trpc6<tm1Dgen>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5427697 Trpc6<tm1Dgen> MGI:109523 Trpc6
No visible phenotype Contact
B6.129P2-Wt1<tm1Hst>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:2654351 Wt1<tm1Hst> MGI:98968 Wt1
No detectable WT* protein isoforms by western blot. No overt phenotype. Contact
B6.129P2-Zfp647<Gt(ES492)Hgs>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:4353070 Zfp647<Gt(ES492)Hgs> MGI:3052806 Zfp647
Homozygotes are embryonic lethal at before 6.5 dpc. Contact
B6.129S-Ctse<129S/SvHsd>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5435247 Ctse<129S/SvHsd> MGI:107361 Ctse
Mice breed normally. No obvious phenotype has been described as yet but cathepsin E has been implicated in regulation of antigen processing, and other aspects of innate immunity. Contact
B6.129S-Otoa<tm1Gpr>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5469411 Otoa<tm1Gpr> MGI:2149209 Otoa
In null mutant (OtoaEGFP/EGFP) mice the TM is detached at the spiral limbus but remains attached to the outer hair cells, Hensen's stripe is missing and the marginal band appears abnormal. Null mutants show hearing loss but excitation of the outer hair cells and cochlear amplification are almost normal. Contact
B6.129S-Tecta<tm1Gpr>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:2183148 Tecta<tm1Gpr> MGI:109575 Tecta
Homozygous mutant mice suffer hearing loss and have detatched tectorial membranes lacking all non-collagenous matrix. Contact
B6.129S-Tecta<tm2Gpr>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:3605485 Tecta<tm2Gpr> MGI:109575 Tecta
Heterozygous mice suffer hearing loss and have tectorial membranes with a thin limbal attachment zone, missing marginal band and Hensen's stripe and large holes in the main body of the matrix. The subtectorial space above the inner hair cells is also enlarged. Heterozygous mice show elevated neural thresholds, broadened neural tuning and a decrease in sensitivity at the tip of the neural tuning curve. Contact
B6.129S-Tectb<tm1Gpr>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:3711698 Tectb<tm1Gpr> MGI:109574 Tectb
Homozygous mutant mice suffer low frequency hearing loss and have normally attached tectorial membranes that lack striated sheet matrix. Hensen's stripe is missing and the marginal band is absent in the apical coil of the cochlea. Sharpness of high frequency tuning is enhanced. Contact
B6.129S1-Gnas<tm2Kel>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:3579575 Gnas<tm2Kel> MGI:95777 Gnas
There is a behavioural phenotype, response to novel environments as measured through activity in various tasks. Contact
B6.129S2-Ctse<tm1Bchn>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5435933 Ctse<tm1Bchn> MGI:107361 Ctse
Mice breed normally. No obvious phenotype has been described as yet but cathepsin E has been implicated in regulation of antigen processing, and other aspects of innate immunity. Contact
B6.129S6-Cln3<tm1Nbm>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:1933976 Cln3<tm1Nbm> MGI:107537 Cln3
Mouse model of Juvenile onset Batten disease (Neuronal Ceroid Luipofuscinosis) Contact
B6.129S6-Rhbdf2<tm1.1Mfm>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5309177 Rhbdf2<tm1.1Mfm> MGI:2442473 Rhbdf2
Contact
B6.129S6-Scn3a<tm1Jwo>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5505504 Scn3a<tm1Jwo> MGI:98249 Scn3a
No obvious defects. Contact
B6.C-Ndrg1<str>/H
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5009138 Ndrg1<str> MGI:1341799 Ndrg1
Mice at first develop normally but around the age of 5-6 weeks develop a peripheral demyelinating neuropathy resulting in weakness of the hind limbs. This manifests as clasping hind legs when suspended by tail, marked tremor, inability to maintain normal posture. Signs progress rapidly at first, stabilise after 20 weeks. Contact
B6.C3-Rab27a<ash> 129-Rab27b<tm1.2Seab>/SeabH
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:1856656 Rab27a<ash> MGI:1861441 Rab27a
MGI:3706986 Rab27b<tm1.2Seab> MGI:1931295 Rab27b
The stock has an abnormal coat colour pigmentation (ashen) due to the recessive mutation Rab27a<ash>. Contact
B6.C3H;B6-Crh<m1H>
Allele MGI ID Allele Name Gene MGI ID Gene Name
MGI:5578654 Crh<m1H> MGI:88496 Crh
Heterozygous Crh<m1H> are obese, exhibit muscle wasting, thin skin, hair loss, elevated plasma and urinary corticosterone, hyperglycaemia, hyperinsulinaemia, hypercholesterolemia, hypertryglyceridemia and hyperleptinaemia. They also have low bone mineral density, hypercalcemia, hypercalciuria and decreased concentrations of plasma PTH and osteocalcin. Heterozygotes can be visibly distinguished from wild types at about 5-6 weeks of age by their short, skinny tails and scruffy coat. They also have thin skin and their hair starts to thin as they age. Contact
B6.CAnNCrl(C3)-Dync1i2<m1H>/EmcfH Currently being tested, trend towards slight locomotor deficit, nothing significant so far. Contact

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